PHARMACEUTICAL COMPOSITIONS AND DOSAGE FORMS FOR ADMINISTRATION OF HYDROPHOBIC DRUGS
First Claim
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1. A pharmaceutical composition comprising:
- a) a carrier comprising;
i) a triglyceride;
ii) at least two surfactants, at least one of the surfactants being a hydrophilic surfactant; and
b) a therapeutically effective amount of a sex hormone;
wherein the triglyceride and surfactants are present in amounts such that upon mixing with an aqueous solution in an aqueous solution to a composition ratio of about 100;
1 by weight, the composition forms a dispersion having an average particle size of less than 200 nm.
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Abstract
The present invention relates to pharmaceutical compositions and methods for improved solubilization of triglycerides and improved delivery of therapeutic agents. Compositions of the present invention include a carrier, where the carrier is formed from a combination of a triglyceride and at least two surfactants, at least one of which is hydrophilic. Upon dilution with an aqueous medium, the carrier forms a clear, aqueous dispersion of the triglyceride and surfactants.
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Citations
62 Claims
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1. A pharmaceutical composition comprising:
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a) a carrier comprising; i) a triglyceride; ii) at least two surfactants, at least one of the surfactants being a hydrophilic surfactant; and b) a therapeutically effective amount of a sex hormone; wherein the triglyceride and surfactants are present in amounts such that upon mixing with an aqueous solution in an aqueous solution to a composition ratio of about 100;
1 by weight, the composition forms a dispersion having an average particle size of less than 200 nm. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. A pharmaceutical composition comprising:
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a) a triglyceride; b) a carrier comprising at least two surfactants, at least one of the surfactants being hydrophilic; and c) a therapeutically effective amount of a sex hormone. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48)
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49. A pharmaceutical composition comprising:
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a) a triglyceride; b) a hydrophilic alcohol transesterified surfactant; and c) a therapeutically effective amount of testosterone, or an ester thereof. - View Dependent Claims (50, 51, 52, 53, 54)
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55. A pharmaceutical composition comprising:
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a) a triglyceride; b) PEG-35 castor oil, PEG-40 castor oil, PEG-40 hydrogenated castor oil, or a combination thereof; and c) a therapeutically effective amount of testosterone, or an ester thereof. - View Dependent Claims (56, 57, 58, 59, 60)
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61. A method of providing hormone therapy in a patient comprising orally administering to a patient in need thereof a pharmaceutical composition comprising:
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a) a therapeutically effective amount of sex hormone; b) a triglyceride; and c) a carrier comprising at least two surfactants, at least one of the surfactants being hydrophilic. - View Dependent Claims (62)
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Specification