Anti-inflammatory compositions and methods
First Claim
Patent Images
1. A therapeutic composition, comprising:
- at least one first agent configured to modulate the activity of one or more Toll-like receptors;
at least one second agent configured to modulate the activity of one or more Src family kinases;
at least one third agent configured to modulate the activity of one or more NF-kB molecules; and
at least one pharmaceutically-acceptable carrier or excipient.
1 Assignment
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Accused Products
Abstract
Certain embodiments disclosed relate to compositions, including therapeutic compositions, methods, devices, and systems that modulate at least one inflammatory response or reaction. According to various embodiments, the compositions, methods, devices, and systems relate to modulating one or more of Toll-like receptors, Src family kinases, NF-kB molecules, proteases, or proteasomes.
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Citations
218 Claims
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1. A therapeutic composition, comprising:
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at least one first agent configured to modulate the activity of one or more Toll-like receptors; at least one second agent configured to modulate the activity of one or more Src family kinases; at least one third agent configured to modulate the activity of one or more NF-kB molecules; and at least one pharmaceutically-acceptable carrier or excipient. - View Dependent Claims (11, 17, 21, 23, 28, 29, 31, 45, 49, 52)
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64. A method of modulating at least one immune response of one or more cells of a subject, comprising:
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administering to the subject an effective amount of at least one therapeutic composition including at least one first agent configured to modulate the activity of one or more Toll-like receptors; at least one second agent configured to modulate the activity of one or more Src family kinases; at least one third agent configured to modulate the activity of one or more NF-kB molecules; and at least one pharmaceutically-acceptable carrier or excipient. - View Dependent Claims (73, 75, 76, 79, 80, 83, 85, 90, 91, 93, 109, 113, 116, 121)
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137. A method of modulating the activity of one or more Toll-like receptors, one or more Src family kinases, and one or more NF-kB molecules in one or more cells of a subject, comprising:
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administering to the subject an effective amount of at least one therapeutic composition, including at least one first agent configured to modulate the activity of one or more Toll-like receptors, at least one second agent configured to modulate the activity of one or more Src family kinases; at least one third agent configured to modulate the activity of one or more NF-kB molecules; and
at least one pharmaceutically-acceptable carrier or excipient. - View Dependent Claims (144, 146, 147, 150, 151, 154, 156, 161, 162, 164, 180, 184, 187, 192)
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208. A method of treating a subject afflicted with or suspected of being afflicted with at least one inflammatory disease or condition, comprising:
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administering to the subject an effective amount of at least one therapeutic composition, including at least one of chloroquine, M62812, or quinine; at least one of dasatinib, nilotinib, BMS-268770, UR-12947, aztreonam, MZ-338, riluzole, meloxicam, pramipexole, CBS-113-A, AZD0530, INNO-406, MK-0457, cediranib, sunitinib, bosutinib, axitinib, erlotinib, gefitinib, lapatinib, lestaurtinib, semaxanib, or imatinib; at least one of disulfiram, ditiocarb, sulindac, sulfasalazine, or bortezomib; and at least one pharmaceutically-acceptable carrier or excipient. - View Dependent Claims (211)
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213. A method of treating a subject afflicted with or suspected of being afflicted with malaria, comprising:
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administering to the subject an effective amount of at least one therapeutic composition, including at least one of chloroquine, M62812, or quinine, at least one of dasatinib, nilotinib, BMS-268770, UR-12947, aztreonam, MZ-338, riluzole, meloxicam, pramipexole, CBS-113-A, AZD0530, INNO-406, MK-0457, cediranib, sunitinib, bosutinib, axitinib, erlotinib, gefitinib, lapatinib, lestaurtinib, semaxanib, or imatinib; and at least one pharmaceutically-acceptable carrier or excipient. - View Dependent Claims (214, 215, 216, 217)
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Specification