Methods for Treating Neuropsychiatric Disorders with NMDA Receptor Antagonists
First Claim
1. A method for treating neuropsychiatric disorders comprising administering to a human patient suffering from a neuropsychiatric disorder, an effective amount of an NMDA receptor antagonist compound to modulate glutamatergic neurotransmission by NMDA receptors in the human patient, thereby treating the neuropsychiatric disorder.
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Abstract
The present invention relates to compositions and methods for treating a human patient afflicted with a neuropsychiatric disorder. Specifically, the invention provides for compositions and methods of modulating or antagonizing the activity of neuronal NMDA receptors, wherein such antagonistic activity is capable of modulating the glutamate induced excitatory response of the neurons, thereby inhibiting an excitotoxic effect, promoting a neurotrophic effect, and thereby providing a therapeutic effect that treats the neuropsychiatric disorder.
103 Citations
37 Claims
- 1. A method for treating neuropsychiatric disorders comprising administering to a human patient suffering from a neuropsychiatric disorder, an effective amount of an NMDA receptor antagonist compound to modulate glutamatergic neurotransmission by NMDA receptors in the human patient, thereby treating the neuropsychiatric disorder.
- 14. A method of using a NMDA receptor antagonist compound to modulate glutamatergic neurotransmission in a human patient comprising administering to a patient suffering from a neuropsychiatric disorder, an effective amount of a NMDA receptor antagonist compound to antagonize NMDA receptors in the human patient, thereby modulating glutamatergic neurotransmission by the NMDA receptors and thereby treating the neuropsychiatric disorder.
- 27. A method of using a NMDA receptor antagonist compound to modulate glutamatergic neurotransmission in a human patient comprising administering to a patient suffering from a neuropsychiatric disorder, an effective amount of NMDA receptor antagonist compound to antagonize the PCP or MK-801 binding site of NMDA receptors in the human patient, thereby modulating excessive glutamatergic neurotransmission by the NMDA receptors, thereby providing the human patient a neuroprotective effect and a neurotropic effect, and thereby treating the neuropsychiatric disorder.
- 32. The use of an NMDA receptor antagonist compound in the manufacture of a medicament to modulate excessive glutamatergic neurotransmission by NMDA receptors for treatment of a human patient suffering from a neuropsychiatric disorder.
Specification