BLOOD FLOW DYNAMIC ANALYSIS APPARATUS AND MAGNETIC RESONANCE IMAGING SYSTEM

• US 20100137703A1
• Filed: 11/24/2009
• Published: 06/03/2010
• Est. Priority Date: 11/28/2008
• Status: Abandoned Application

• Current Assignee: GE Medical Systems Global Technology Company LLC (GE Healthcare Technologies, Inc.)
• Original Assignee: GE Medical Systems Global Technology Company LLC (GE Healthcare Technologies, Inc.)
• Inventors: Kabasawa, Hiroyuki
• Application Number:
  US12/625,246
• Publication Number:
  US 20100137703A1
• Time in Patent Office: Days
• US Class Current: 600/419
• CPC Class Codes: A61B 5/0263 using NMR
• CPC Class Codes: A61B 5/0275 using tracers, e.g. dye dilution
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/704 Tables
• CPC Class Codes: G01R 33/4835 of multiple slices
• CPC Class Codes: G01R 33/5601 involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
• CPC Class Codes: G01R 33/56366 Perfusion imaging

Abstract

A blood flow dynamic analysis apparatus for determining a baseline indicative of a signal strength prior to an arrival of a contrast agent to a predetermined region of a subject, based on MR signals collected in time series from the predetermined region of the subject with the contrast agent injected therein, includes a time detection unit for detecting a time of data minimal in signal strength, of a first data sequence in which data of signal strengths of the MR signals are arranged in time series, a data fetch unit for fetching a second data sequence which appears prior to the time detected by the time detection unit, from within the first data sequence, a data detection unit for detecting centrally-located data from within a third data sequence obtained by sorting the second data sequence in the order of magnitudes of the signals strengths, a data extraction unit for extracting data from the third data sequence, based on the centrally-located data, and a baseline determination unit for determining the baseline, based on the data extracted by the data extraction unit.

Claims

1. A blood flow dynamic analysis apparatus configured to determine a baseline indicative of a signal strength prior to an arrival of a contrast agent to a predetermined region of a subject, based on MR signals collected in time series from the predetermined region of the subject said blood flow dynamic analysis apparatus comprising:

a time detection unit configured to detect a time of data having a minimal signal strength, of a first data sequence in which data of signal strengths of the MR signals are arranged in time series;

a data fetch unit configured to fetch a second data sequence which appears prior to the time detected by said time detection unit, from within the first data sequence;

a data detection unit configured to detect centrally-located data from within a third data sequence obtained by sorting the second data sequence in the order of magnitudes of the signals strengths;

a data extraction unit configured to extract data from the third data sequence, based on the centrally-located data; and

a baseline determination unit configured to determine the baseline, based on the data extracted by said data extraction unit.

2. The blood flow dynamic analysis apparatus according to claim 1, wherein said baseline determination unit comprises:

a labeling part configured to label data within the second data sequence that corresponds to the data extracted from the third data sequence;

a data determination part configured to determine data used to determine the baseline, based on the labeled data; and

a baseline determination part configured to determine the baseline, based on the data determined by said data determination part.

3. The blood flow dynamic analysis apparatus according to claim 2, wherein when unlabeled third data exists between labeled first data and labeled second data, said data determination part is configured to determine the third data as the data used to determine the baseline along with the first data and the second data.

4. The blood flow dynamic analysis apparatus according to claim 2, further comprising an arrival time determination unit configured to determine an arrival time at which the contrast agent reaches the predetermined region, based on the labeled data.

5. The blood flow dynamic analysis apparatus according to claim 3, further comprising an arrival time determination unit configured to determine an arrival time at which the contrast agent reaches the predetermined region, based on the labeled data.

6. The blood flow dynamic analysis apparatus according to claim 4, wherein said arrival time determination unit is configured to determine the arrival time using a function for performing a fitting process.

7. The blood flow dynamic analysis apparatus according to claim 5, wherein said arrival time determination unit is configured to determine the arrival time using a function for performing a fitting process.

8. The blood flow dynamic analysis apparatus according to claim 1, wherein said data extraction unit comprises:

a data tentative extraction part configured to tentatively extract data from within the third data sequence, based on the centrally-located data;

a confidence interval determination part configured to determine a confidence interval for the tentatively extracted data; and

a data extraction part configured to extract data contained in the confidence interval from within the tentatively extracted data.

9. The blood flow dynamic analysis apparatus according to claim 8, wherein said confidence interval determination part is configured to calculate an average value of the data extracted from the data extraction part and a standard deviation thereof, and to calculate the confidence interval, based on the average value and the standard deviation.

10. The blood flow dynamic analysis apparatus according to claim 1, further comprising a sort unit configured to sort the second data sequence in the order of magnitudes of the signal strengths.

11. The blood flow dynamic analysis apparatus according to claim 8, further comprising a sort unit configured to sort the second data sequence in the order of magnitudes of the signal strengths.

12. The blood flow dynamic analysis apparatus according to claim 1, wherein said data fetch unit is configured to fetch the data at the time detected by said time detection unit from within the first data sequence as the data contained in the second data sequence.

13. The blood flow dynamic analysis apparatus according to claim 8, wherein said data fetch unit is configured to fetch the data at the time detected by said time detection unit from within the first data sequence as the data contained in the second data sequence.

14. A magnetic resonance imaging system comprising;

a contrast injection device configured to inject a contrast into a predetermined region of a subject; and

a blood flow dynamic analysis apparatus configured to determine a baseline indicative of a signal strength prior to an arrival of the contrast agent into the predetermined region, based on MR signals collected in time series from the predetermined region, said blood flow dynamic analysis apparatus comprising;

a time detection unit configured to detect a time of data having a minimal signal strength, of a first data sequence in which data of signal strengths of the MR signals are arranged in time series;

a data fetch unit configured to fetch a second data sequence which appears prior to the time detected by said time detection unit, from within the first data sequence;

a data detection unit configured to detect centrally-located data from within a third data sequence obtained by sorting the second data sequence in the order of magnitudes of the signals strengths;

a data extraction unit configured to extract data from the third data sequence, based on the centrally-located data; and

a baseline determination unit configured to determine the baseline, based on the data extracted by said data extraction part.

16. The magnetic resonance imaging system according to claim 14, wherein said baseline determination unit comprises:

a labeling part configured to label data within the second data sequence that corresponds to the data extracted from the third data sequence;

a data determination part configured to determine data used to determine the baseline, based on the labeled data; and

a baseline determination part configured to determine the baseline, based on the data determined by said data determination part.

17. The magnetic resonance imaging system according to claim 16, wherein when unlabeled third data exists between labeled first data and labeled second data, said data determination part is configured to determine the third data as the data used to determine the baseline along with the first data and the second data.

18. The magnetic resonance imaging system according to claim 16, further comprising an arrival time determination unit configured to determine an arrival time at which the contrast agent reaches the predetermined region, based on the labeled data.

15. A magnetic resonance imaging system comprising:

a contrast injection device configured to inject a contrast into a predetermined region of a subject; and

a blood flow dynamic analysis apparatus configured to determine a baseline indicative of a signal strength prior to an arrival of the contrast agent into the predetermined region, based on MR signals collected in time series from the predetermined region, said blood flow dynamic analysis apparatus comprising;

a time detection unit configured to detect a time of data having a minimal signal strength, of a first data sequence in which data of signal strengths of the MR signals are arranged in time series;

a data fetch unit configured to fetch a second data sequence which appears prior to the time detected by said time detection unit, from within the first data sequence;

a data detection unit configured to detect centrally-located data from within a third data sequence obtained by sorting the second data sequence in the order of magnitudes of the signals strengths;

a data tentative extraction part configured to tentatively extract data from within the third data sequence, based on the centrally-located data;

a confidence interval determination part configured to determine a confidence interval for the tentatively extracted data;

a data extraction part configured to extract data contained in the confidence interval from within the tentatively extracted data; and

a baseline determination unit configured to determine the baseline, based on the data extracted by said data extraction unit.

19. The magnetic resonance imaging system according to claim 15, wherein said baseline determination unit comprises:

a labeling part configured to label data within the second data sequence that corresponds to the data extracted from the third data sequence;

a data determination part configured to determine data used to determine the baseline, based on the labeled data; and

a baseline determination part configured to determine the baseline, based on the data determined by said data determination part.

20. The magnetic resonance imaging system according to claim 19, further comprising an arrival time determination unit configured to determine an arrival time at which the contrast agent reaches the predetermined region, based on the labeled data.