Device for Predicting and Managing Blood Glucose by Analyzing the Effect of, and Controlling, Pharmacodynamic Insulin Equivalents

• US 20100138197A1
• Filed: 11/01/2007
• Published: 06/03/2010
• Est. Priority Date: 11/01/2006
• Status: Active Grant

• Current Assignee: Philip Michael Sher
• Original Assignee: Philip Michael Sher
• Inventors: Sher, Philip Michael
• Granted Patent: US 8,204,729 B2
• Time in Patent Office: Days
• US Class Current: 703/2
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: G16H 15/00 ICT specially adapted for medical reports, e.g. generation or transmission thereof
• CPC Class Codes: G16H 20/17 delivered via infusion or injection
• CPC Class Codes: G16H 50/50 for simulation or modelling of medical disorders

Abstract

Embodiments of the invention are devices for assisting users in the management of blood glucose concentration levels in patients. Devices of the invention provide users with detailed information related to the pharmacodynamic behavior of insulin in a patient. By displaying and accepting information concerning time-dependent rates and amounts of pharmacodynamic insulin unit equivalents, the devices of the invention empower the user to make effective decisions regarding insulin dosing.

Claims

1. A device for managing blood glucose concentration comprising:

a means for inputting at least two recent past blood glucose concentration data items, each data item comprising a blood glucose concentration value and a time-of-measurement value;

a means for inputting insulin delivery data items, each data item comprising an insulin dosage amount and a time-of-delivery value;

a means for inputting insulin time-action profile data;

a means for inputting patient R_BGC/I data, the responsiveness of the patient'"'"'s blood glucose concentration to insulin, optionally as a function of time of day;

a means for inputting phamacodynamic insulin unit equivalent expenditure data, the data selected from the group consisting of;

d(PDIUE)/dt data, a rate of pharmacodynamic insulin unit equivalent expenditure; and

2. The device of claim 1 wherein t₁ and t_1a are no more than five hours in the past, where t₂ and t_2a are no more than seven hours in the future, and where d(PDIUE)/dt corresponds to a time no more than five hours in the past and no more than seven hours in the future.

3. The device of claim 1 wherein the calculated and displayed d(PDIUE)/dt and

4. The device of claim 1 wherein the inputted d(PDIUE)/dt and

5. The device of claim 2 wherein the inputted d(PDIUE)/dt and

6. The device of claim 5 wherein a means for inputting data comprises at least one of:

a keyboard;

a touch screen.

7. The device of claim 6 further comprising at least one of:

a glucose meter connected to the microprocessor,

whereby at least two recent blood glucose data items are inputted;

an insulin pump connected to the microprocessor,

whereby insulin delivery data items are inputted.

8. A device for managing blood glucose concentration comprising:

a means for inputting at least two recent past blood glucose concentration data items, each data item comprising a blood glucose concentration value and a time-of-measurement value;

a means for inputting insulin delivery data items, each data item comprising an insulin dosage amount and a time-of-delivery value;

a means for inputting insulin time-action profile data;

a means for inputting patient R_BGC/I data, the responsiveness of the patient'"'"'s blood glucose concentration to insulin, optionally as a function of time of day;

a means for inputting phamacodynamic insulin unit equivalent expenditure data, the data selected from the group consisting of;

d(PDIUE)/dt data, a rate of pharmacodynamic insulin unit equivalent expenditure; and

9. The device of claim 8 wherein t₁ and t_1a are no more than five hours in the past, where t₂ and t_2a are no more than seven hours in the future, and where d(PDIUE)/dt corresponds to a time no more than five hours in the past and no more than seven hours in the future.

10. The device of claim 8 wherein the calculated and displayed d(PDIUE)/dt and

11. The device of claim 8 wherein the inputted d(PDIUE)/dt and

12. The device of claim 9 wherein the inputted d(PDIUE)/dt and

13. The device of claim 12 wherein a means for inputting data comprises at least one of:

a keyboard;

a touch screen.

14. The device of claim 13 further comprising at least one of:

a glucose meter connected to the microprocessor,

whereby at least two recent blood glucose data items are inputted;

an insulin pump connected to the microprocessor,

whereby insulin delivery data items are inputted.

15. A device for managing blood glucose concentration comprising:

a means for inputting insulin delivery data items, each data item comprising an insulin dosage amount and a time-of-delivery value;

a means for inputting insulin time-action profile data;

a means for inputting phamacodynamic insulin unit equivalent expenditure data, the data selected from the group consisting of;

d(PDIUE)/dt data, a rate of pharmacodynamic insulin unit equivalent expenditure; and

16. The device of claim 15 wherein t₁ and t_1a are no more than five hours in the past, where t₂ and t_2a are no more than seven hours in the future, and where d(PDIUE)/dt corresponds to a time no more than five hours in the past and no more than seven hours in the future.

17. The device of claim 16 wherein a means for inputting data comprises at least one of:

a keyboard;

a touch screen.

18. The device of claim 17 wherein a means for inputting insulin delivery data items comprises an insulin pump connected to the microprocessor.

19. A device for managing blood glucose concentration comprising:

a means for inputting insulin delivery data items, each data item comprising an insulin dosage amount and a time-of-delivery value;

a means for inputting insulin time-action profile data;

a microprocessor connected to the input means;

the microprocessor connected to a digital memory;

the microprocessor connected to wired or wireless communication means;

the microprocessor configured to perform calculations based upon inputted insulin delivery data;

inputted insulin time-action profile data;

the microprocessor configured to calculate an item selected from the group consisting of;

d(PDIUE)/dt, a rate of pharmacodynamic insulin unit equivalent expenditure; and

20. The device of claim 19 wherein a means for inputting data comprises at least one of:

a keyboard;

a touch screen.

21. The device of claim 20 wherein a means for inputting insulin delivery data items comprises an insulin pump connected to the microprocessor.

22. A device for managing blood glucose concentration comprising:

a means for inputting insulin time-action profile data;

a means for inputting phamacodynamic insulin unit equivalent expenditure data, the data selected from the group consisting of;

d(PDIUE)/dt data, a rate of pharmacodynamic insulin unit equivalent expenditure; and

23. The device of claim 22 wherein a means for inputting data comprises at least one of:

a keyboard;

a touch screen.

24. The device of claim 22 further configured to output an insulin delivery-over-time function to an insulin pump.

25. The device of claim 22 wherein the microprocessor is connected to wired or wireless communication means.