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POLYPEPTIDE FRAGMENTS OF THE HEPATITIS E VIRUS, THE VACCINE COMPOSITION COMPRISING SAID FRAGMENTS AND THE DIAGNOSTIC KITS

  • US 20100143410A1
  • Filed: 09/11/2009
  • Published: 06/10/2010
  • Est. Priority Date: 09/30/2000
  • Status: Active Grant
First Claim
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1. A polypeptide consisting of a fragment of an amino acid sequence as set forth in SEQ ID No. 1 of hepatitis E virus ORF 2, which fragment is selected from the group consisting of:

  • 1) A polypeptide wherein the amino terminus starts from between amino acid residues 414 and 459, and the carboxyl terminus ends at amino acid residue 660 from SEQ ID No;

    1;

    2) A polypeptide wherein the amino acid sequence of amino acid residues 414 to 660 from SEQ ID No;

    1, i.e., polypeptide 247;

    3) A polypeptide wherein the amino acid sequence of amino acid residues 429 to 660 from SEQ ID No;

    1, i.e., polypeptide 232;

    4) A polypeptide wherein the amino acid sequence of amino acid residues 439 to 660 from SEQ ID NO;

    1, i.e., polypeptide 222;

    5) A polypeptide wherein the amino acid sequence of amino acid residues 459 to 660 from SEQ ID NO;

    1, i.e., polypeptide 201;

    6) A polypeptide having at least 80% homology to any one of the preceding polypeptides of the above

         1)-5) and having substantially identical antigenicity or immunogenicity.

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