SYSTEMS AND METHODS FOR BIODOSIMETRY WITH BIOCHIP USING GENE EXPRESSION SIGNATURES
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Abstract
Exposure to ionizing radiation can produce a well-defined dose dependent signature in terms of changes in gene expression. In approaches and devices described herein, such a signature can be used to generate and use a self-contained radiation biodosimeter device, based on, for example, a blood finger stick. Various aspects of the invention are directed to biodosimetry with a fully integrated biochip using gene expression signatures.
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Citations
101 Claims
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1-56. -56. (canceled)
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57. A portable biodosimetry device for detecting radiation exposure, comprising:
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a microfluidic biochip comprising; a biological sample collection module; an oligonucleotide extraction module; a hybridization channel module; a power module; and a control module; wherein, the hybridization channel module comprises an oligonucleotide array; the oligonucleotide array of the hybridization channel module comprises a plurality of oligonucleotides, where an oligonucleotide of the array will hybridize under stringent conditions to a gene expression product of a radiation responsive gene; and the biological sample collection module, the oligonucleotide extraction module, and the hybridization channel module are fluidically coupled. - View Dependent Claims (58, 59, 60, 62, 65, 67, 68, 70, 72, 76, 77, 84, 85, 87, 88, 90, 96, 97, 98, 99, 100)
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Specification