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METHODS OF TREATING PSYCHOSIS AND SCHIZOPHRENIA BASED ON POLYMORPHISMS IN THE ERBB4 GENE

  • US 20100144781A1
  • Filed: 10/29/2009
  • Published: 06/10/2010
  • Est. Priority Date: 10/29/2008
  • Status: Abandoned Application
First Claim
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1. A method for predicting likelihood of a patient responding to treatment with an atypical antipsychotic drug selected from the group consisting of Paliperidone, and pharmaceutically acceptable salts and esters thereof, comprising:

  • a) analyzing nucleotide sequences of two alleles of the ErbB4 gene in said patient;

    b) determining a genotype at a polymorphic site in the ErbB4 gene, wherein said polymorphic site is at 201 in SEQ ID NO;

    1; and

    c) identifying the patient with the genotype of GA or GG as being more likely to respond to the drug, and the patient with the genotype of AA as being less likely to respond to the drug.

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