CONTROL OF NK CELL FUNCTION AND SURVIVAL BY MODULATION OF SHIP ACTIVITY
First Claim
1. A method for treating or preventing graft-versus-host disease (GvHD) in a patient having or in need of a transplant, comprising administering to said patient an efficacious amount of a substance that inhibits SHIP function, in a pharmaceutically acceptable carrier.
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Accused Products
Abstract
Inhibition of dendritic cell function in solid organ grafts or allogeneic bone marrow transplants prior to or during engraftment by blocking SH2-containing inositol phosphatase (SHIP) expression or function is taught as a method of abrogating immune rejection and thereby increasing the efficacy of engraftment of an allogeneic bone marrow transplant or solid organ allograft or xenograft. Also disclosed is a transgenic mouse having the genotype SHIP−/− which exhibits enhanced survival following mismatched allogeneic marrow grafts.
51 Citations
6 Claims
- 1. A method for treating or preventing graft-versus-host disease (GvHD) in a patient having or in need of a transplant, comprising administering to said patient an efficacious amount of a substance that inhibits SHIP function, in a pharmaceutically acceptable carrier.
Specification