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RNAi-MEDIATED INHIBITION OF H1F1A FOR TREATMENT OF OCULAR ANGIOGENESIS

  • US 20100144844A1
  • Filed: 02/16/2010
  • Published: 06/10/2010
  • Est. Priority Date: 12/29/2005
  • Status: Active Grant
First Claim
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1. A method of attenuating expression of HIF1A mRNA in a subject, the method comprising:

  • administering to the subject a composition comprising an effective amount of interfering RNA having a length of 19 to 49 nucleotides and a pharmaceutically acceptable carrier, the interfering RNA comprising;

    a region of at least 13 contiguous nucleotides having at least 90% sequence complementarity to, or at least 90% sequence identity with, the penultimate 13 nucleotides of the 3′

    end of an mRNA corresponding to any one of SEQ ID NO;

    3, SEQ ID NO;

    9-SEQ ID NO;

    48, and SEQ ID NO;

    50-SEQ ID NO;

    51,wherein the expression of HIF1A mRNA is thereby attenuated.

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