Universal Electrode Array for Monitoring Brain Activity

• US 20100145176A1
• Filed: 12/03/2009
• Published: 06/10/2010
• Est. Priority Date: 12/04/2008
• Status: Abandoned Application

• Current Assignee: Cyberonics, Inc
• Original Assignee: Cyberonics, Inc
• Inventors: Himes, David M.
• Application Number:
  US12/630,300
• Publication Number:
  US 20100145176A1
• Time in Patent Office: Days
• US Class Current: 600/378
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/291 for electroencephalography [EEG]
• CPC Class Codes: A61B 5/4064 Evaluating the brain A61B5/031, A61B5/369, A61B5/14553 take precedence
• CPC Class Codes: A61B 5/4094 Diagnosing or monitoring seizure diseases, e.g. epilepsy
• CPC Class Codes: A61B 5/6868 Brain

Abstract

Methods of monitoring brain activity signals in a patient are described, including the steps of identifying a lobe or lobes of the patient'"'"'s brain in which the patient'"'"'s seizures originate; selecting an electrode array from a plurality of predetermined dispersed electrode patterns based on the identified lobe or lobes of the brain; implanting the electrode array within the patient'"'"'s cranium to place the electrodes in contact with the identified lobe or lobes of the brain; and coupling the electrodes to an seizure advisory system. Also described is a seizure advisory system that includes an electrode array having fewer than 32 electrodes in a predetermined dispersed radial pattern, adapted to be implanted through a single opening in the skull, and to be deployed in the predetermined dispersed radial pattern to detect a brain activity signal. The system also includes a communication assembly and an external assembly.

Claims

1. A method of monitoring brain activity signals in a patient, the method comprising:

identifying a lobe or lobes of the brain in which the patient'"'"'s seizures originate;

selecting an electrode array from a plurality of predetermined dispersed electrode array patterns based on the identified lobe or lobes of the brain;

implanting the electrode array within the patient'"'"'s cranium to place the electrodes in contact with the identified lobe or lobes of the brain; and

coupling electrodes to a seizure advisory system.

2. The method of claim 1 wherein identifying the lobe or lobes of the brain comprises identifying a lobe or lobes of the brain in which the patient'"'"'s seizures originate without localization of a seizure focus.

3. The method of claim 1 wherein the electrode array comprises a furcated electrode substrate.

4. The method of claim 1 wherein the implanting step comprises implanting the electrode array to cover a portion of a cortical surface of the brain which cannot be circumscribed by a radius of 4 cm.

5. The method of claim 1 wherein the lobe or lobes of the brain comprise the frontal and temporal lobe, wherein implanting the electrode array comprises:

implanting a first electrode array parallel to an interhemispheric fissure in the patient;

implanting a second electrode array spanning between a precentral sulcus to an anterior edge of a temporal pole;

implanting a third electrode array spanning between the precentral sulcus to the temporal pole; and

implanting a fourth electrode array spanning between the precentral sulcus to a posterior portion of a Sylvian Fissure.

6. The method of claim 5 further comprising surgically exposing part of a skull and creating a single opening approximately 1 cm anterior to the precentral sulcus and 1 cm lateral to the interhemispheric fissure and implanting the electrode arrays through the opening.

7. The method of claim 5 wherein at least one electrode array comprises 4 separate electrodes which are linearly spaced 20 mm apart from adjacent electrodes of the same array.

8. The method of claim 1 where the lobe or lobes of the brain comprise the temporal lobe wherein implanting the plurality of electrodes comprises:

implanting a first electrode array spanning from a middle temporal gyrus in line with a spinal cord to a temporal pole;

implanting a second electrode array is inserted mesially from the middle temporal gyrus in line with the spinal cord and wrapping under the temporal lobe;

implanting a third electrode array spanning from the middle temporal gyrus in line with the spinal cord posteriorly along the middle temporal gyrus; and

implanting a fourth electrode array spanning from the middle temporal gyrus in line with the spinal into the temporal lobe both anteriorly and superiorly, passing approximately perpendicular to a Sylvian fissure.

9. The method of claim 8 further comprising surgically exposing part of the skull and creating a single opening over the middle temporal gyrus in line with the spinal cord and implanting the electrode arrays through the opening.

10. The method of claim 8 wherein the first, second and third electrode arrays each comprise 4 separate electrodes which are linearly spaced 10 mm apart from adjacent electrodes of the same array and the fourth electrode array comprises 4 separate electrodes which are linearly spaced 20 mm apart from adjacent electrodes of the same array.

11. The method of claim 1 where the lobe or lobes of the brain comprise the temporal and parietal lobes, wherein implanting the plurality of electrodes comprises;

implanting a first electrode array spanning between a precentral sulcus to an anterior edge of a temporal pole;

implanting a second electrode array spanning between the precentral sulcus the temporal pole;

implanting a third electrode array spanning between the precentral sulcus to a posterior portion of the Sylvian Fissure; and

implanting a fourth electrode array spanning from the precentral sulcus posteriorly, approximately parallel to an interhemispheric fissure, projecting towards an occipital lobe.

12. The method of claim 11 further comprising surgically exposing part of the skull and creating a single opening approximately 1 cm anterior to the precentral sulcus and 1 cm lateral to the interhemispheric fissure and implanting the electrode arrays through the opening.

13. The method of claim 11 wherein each electrode array comprises 4 separate electrodes which are linearly spaced 20 mm apart from adjacent electrodes of the same array.

14. An EEG electrode array comprising:

a substrate; and

a plurality of electrodes comprising no more than 32 electrodes disposed on the substrate;

the array being configured to be inserted through a single opening in a patient cranium and dispersed on a cortical surface of the brain radially away from the opening.

15. The electrode array of claim 14 wherein the electrodes are dispersed in a radial pattern larger than a circle having a radius of 4 cm.

16. The electrode array of claim 14 wherein the plurality of electrodes comprises 16 electrodes.

17. The electrode array of claim 14 further comprising two lead bodies, each lead body comprising:

a proximal end configured to couple to an implantable seizure advisory system; and

a bifurcated distal region having a first and second branch,

each branch having an electrode array comprising 4 electrodes.

18. The electrode array of claim 14 wherein the EEG electrode array is configured for implantation within a frontal and temporal lobe and comprises four electrode arrays, comprising:

a first electrode array adapted to be implanted parallel to an interhemispheric fissure in the patient;

a second electrode array adapted to span between a precentral sulcus to an anterior edge of a temporal pole;

a third electrode array adapted to span between the precentral sulcus to the temporal pole; and

a fourth electrode array adapted to span between the precentral sulcus to a posterior portion of a Sylvian Fissure.

19. The electrode array of claim 14 wherein the EEG electrodes are configured for implantation within a temporal lobe and comprises four electrode arrays, comprising:

a first electrode array adapted to span from a middle temporal gyrus in line with a spinal cord to a temporal pole;

a second electrode array adapted to be inserted mesially from the middle temporal gyrus in line with the spinal cord and wrapping under the temporal lobe;

a third electrode array adapted to span from the middle temporal gyrus in line with the spinal cord posteriorly along the middle temporal gyrus; and

a fourth electrode array adapted to span from the middle temporal gyrus in line with the spinal cord into the temporal lobe both anteriorly and superiorly, passing approximately perpendicular to a Sylvian fissure.

20. The electrode array of claim 14 wherein the EEG electrodes are configured for implantation within a temporal and parietal lobes comprising:

a first electrode array adapted to span between a precentral sulcus to an anterior edge of a temporal pole;

a second electrode array adapted to span between the precentral sulcus the temporal pole;

a third electrode array adapted to span between the precentral sulcus to a posterior portion of the Sylvian Fissure; and

a fourth electrode array adapted to span from the precentral sulcus posteriorly, approximately parallel to an interhemispheric fissure, projecting towards an occipital lobe.

21. A seizure advisory system comprising:

an electrode array having fewer than 32 electrodes in a predetermined dispersed pattern adapted to be implanted through a single opening in the skull of a patient and deployed in the predetermined dispersed radial pattern to detect a brain activity signal;

a communication assembly adapted to be implanted in the patient in communication with the electrode array, the communication assembly being configured to sample the brain activity signal with the electrode array;

an external assembly adapted to be positioned outside the patient'"'"'s body and to receive a data signal from the communication assembly to indicate the patient'"'"'s susceptibility to a seizure.

22. A seizure advisory system of claim 21 wherein the opening is a burr hole.

23. A seizure advisory system of claim 21 wherein the electrode array has no depth electrodes.

24. A seizure advisory system of claim 21 wherein spacing between adjacent electrodes within the same array is between 10 and 20 mm.

25. The seizure advisory system of claim 21 wherein the electrode array is configured for implantation within a frontal and temporal lobe of the patient'"'"'s brain, wherein the electrode array comprises:

a first electrode array adapted to be implanted parallel to an interhemispheric fissure;

a second electrode array adapted to span between a precentral sulcus to an anterior edge of a temporal pole;

a third electrode array adapted to span between the precentral sulcus to the temporal pole; and

a fourth electrode array adapted to span between the precentral sulcus to a posterior portion of a Sylvian Fissure.

26. The seizure advisory system of claim 21 wherein the electrode array is configured for implantation within a temporal lobe of the patient'"'"'s brain, wherein the electrode array comprises:

a first electrode array adapted to span from a middle temporal gyms in line with a spinal cord to a temporal pole;

a second electrode array adapted to be inserted mesially from the middle temporal gyrus in line with the spinal cord and to wrap under the temporal lobe;

a third electrode array adapted to span from the middle temporal gyrus in line with the spinal cord posteriorly along the middle temporal gyms; and

a fourth electrode array adapted to span from the middle temporal gyrus in line with the spinal into the temporal lobe both anteriorly and superiorly, passing approximately perpendicular to a Sylvian fissure.

27. The seizure advisory system of claim 21 wherein the EEG electrode array is configured for implantation within temporal and parietal lobes of the patient'"'"'s brain, wherein the electrode array comprises:

a first electrode array adapted to span between a precentral sulcus to an anterior edge of a temporal pole;

a second electrode array adapted to span between the precentral sulcus and the temporal pole;

a third electrode array adapted to span between the precentral sulcus to a posterior portion of the Sylvian Fissure; and

a fourth electrode array adapted to span from the precentral sulcus posteriorly, approximately parallel to an interhemispheric fissure, to project towards an occipital lobe.

28. A method of positioning electrodes for monitoring brain activity signals in a patient, the method comprising:

identifying a lobe or lobes of the patient'"'"'s brain in which the patient'"'"'s seizures originate;

positioning 32 or fewer electrodes in a dispersed pattern on a surface of the brain such that the disperse pattern cannot be circumscribed by a circle having a radius of 4 cm projected onto the brain surface; and

coupling the plurality of electrode arrays to a seizure advisory system.

29. The method of claim 28 wherein identifying the lobe or lobes of the brain comprises identifying a lobe or lobes of the brain in which the patient'"'"'s seizures originate without localization of a seizure focus.

30. The method of claim 28 wherein identifying the lobe or lobes of the brain comprises locating a seizure focus within the lobe or lobes of the brain, and positioning the plurality of electrodes comprises ensuring that at least one of the plurality of electrodes is in proximity to the seizure focus.

31. The method of claim 28, wherein a first electrode and a second electrode of the plurality of electrodes are spaced greater than 8 cm apart.

32. The method of claim 28 further comprising processing signals from at least one of the plurality of electrodes to estimate the patient'"'"'s susceptibility for a seizure.

33. The method of claim 28 further comprising wirelessly transmitting a signal from the seizure advisory system to an external device.

34. The method of claim 28 wherein a portion of the seizure advisory system is implanted within the patient'"'"'s body.

35. The method of claim 28 wherein positioning the plurality of electrodes comprises inserting all of the electrodes through a single opening in the skull.

36. The method of claim 35 wherein the opening is a burr hole.

37. The method of claim 28 wherein positioning the plurality of electrodes comprises positioning the plurality of electrodes on dura mater of the patient'"'"'s brain.

38. The method of claim 28 wherein positioning the plurality of electrodes comprises positioning the plurality of electrodes underneath dura mater and on a cortical surface of the patient'"'"'s brain.

39. The method of claim 28 wherein positioning the plurality of electrodes comprises positioning two or more substrates supporting the plurality of electrodes in a dispersed pattern on the surface of the brain.

40. The method of claim 39 wherein the substrates are coupled to a common lead body adapted to connect to the seizure advisory system.