SPRAY ADMINISTRATION OF COMPOSITIONS INCLUDING ACTIVE AGENTS SUCH AS PEPTIDES TO THE GASTROINTESTINAL TRACT
First Claim
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1. A device for administering a sprayable composition including an active agent to a luminal wall of the gastrointestinal tract of a subject, comprising:
- a) a sprayer configured for deployment in a gastrointestinal tract;
b) a pressure generator configured to dispense a dose of sprayable composition out through said sprayer as a spray upon actuation; and
c) an actuator for actuating said pressure generator upon being triggered.
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Abstract
Methods of administering an active agent such as an active pharmaceutical ingredient by spraying a composition comprising the active agent at a luminal wall of the gastrointestinal tract are disclosed. Also disclosed are devices for administering a composition suitable for implementing the disclosed method. Also disclosed is the use of a peptide as an active agent for the manufacture of a sprayable composition for use in the treatment of a subject by gastrointestinal administration.
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Citations
56 Claims
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1. A device for administering a sprayable composition including an active agent to a luminal wall of the gastrointestinal tract of a subject, comprising:
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a) a sprayer configured for deployment in a gastrointestinal tract; b) a pressure generator configured to dispense a dose of sprayable composition out through said sprayer as a spray upon actuation; and c) an actuator for actuating said pressure generator upon being triggered. - View Dependent Claims (2, 3, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56)
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4-35. -35. (canceled)
Specification