DEVICE FOR DELIVERY OF A SUBSTANCE

• US 20100145316A1
• Filed: 12/18/2007
• Published: 06/10/2010
• Est. Priority Date: 12/18/2006
• Status: Active Grant

• Current Assignee: Eatlittle Incorporated
• Original Assignee: Electronic Dietary Foods Inc.
• Inventors: Yadid-Pecht, Orly, Fattouche, Michel, Mintchev, Martin
• Granted Patent: US 8,795,721 B2
• Time in Patent Office: Days
• US Class Current: 604/890.100
• CPC Class Codes: A61K 9/0065 Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
• CPC Class Codes: A61K 9/009 Sachets, pouches characterised by the material or function of the envelope with gastric retention A61K9/0065; sachets which are not administered but function merely as a container are classified according to the content, e.g. sachets comprising powder for reconstitution of a drink A61K9/0095
• CPC Class Codes: A61L 31/146 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61M 29/02 Dilators made of swellable material balloon catheters for angioplasty A61M25/104
• CPC Class Codes: A61M 31/00 Devices for introducing or retaining media, e.g. remedies, in cavities of the body A61M25/00 takes precedence ; introducing or retaining ophthalmic products into the ocular cavities A61F9/0008
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50

Abstract

A device for delivering a substance in situ in a body comprising at least one permeable expandable container having a first dimension and a second dimension and having contained therein the substance to be delivered; and at least one expandable particle comprising a swellable material contained within the container and capable of expanding when contacted with a fluid; whereby when the device is positioned in situ, bodily fluid permeates the container causing the at least one expandable particle contained therein to swell and the container to expand from the first dimension to the second dimension so that the device remains in situ for a period of time sufficient to achieve the desired delivery of the substance is provided.

Claims

1. A device for delivering a substance in situ in a body, comprising:

(a) at least one permeable expandable container having a first dimension and a second dimension and having contained therein the substance to be delivered; and

(b) at least one expandable particle comprising a swellable material contained within the container and capable of expanding when contacted with a fluid;

whereby when the device is positioned in situ, bodily fluid permeates the container causing the at least one expandable particle contained therein to swell and the container to expand from the first dimension to the second dimension so that the device remains in situ for a period of time sufficient to achieve the desired delivery of the substance.

2. The device as claimed in claim 1, wherein the substance is releasably associated with the at least one expandable particle.

3. The device as claimed in claim 1, further comprising at least one substance carrying particle contained within the container, whereby the substance is releasably associated with the at least one substance carrying particle.

4. The device as claimed in claim 1 comprising at least two containers, whereby the containers are releasably coupled to one another by a coupling member.

5. The device as claimed in claim 1, further comprising a carrier, whereby the at least one container is releasably coupled to the carrier by a coupling member.

6. The device as claimed in claim 4, whereby the coupling member is selected from the group comprising a absorbable biodegradable surgical suture, a piece of biodegradable medical gauze, an absorbable net-like nanostructure, biocompatible glue, or combinations thereof.

7. The device as claimed in claim 5, the carrier having a compartment, whereby the carrier further comprises at least one decoupler located in the compartment for decoupling the at least one permeable expandable container from the carrier.

17. The device as claimed in claim 1, further comprising a dissolvable shell for encapsulating the device.

19. A method for delivering a substance in a given cavity or orifice of a body, comprising:

(a) administering at least one substance delivery device as claimed in claim 1 into the cavity or orifice;

(b) contacting the substance delivery device with bodily fluids to allow for the expandable particles to swell and prevent the substance delivery device from exiting the orifice or the cavity;

(c) allowing the substance to be released from the substance releasing device; and

(d) after a desired period of time, allowing the substance delivery device to disassemble so that it can harmlessly exit from the body or be rapidly absorbed.

8. A device for delivering a substance in situ in a body, comprising:

(a) at least one permeable expandable container having a first dimension and a second dimension and containing at least one expandable particle comprising a swellable material capable of expanding when contacted with a fluid;

(b) at least one substance-holding container containing the substance to be delivered; and

(c) at least one coupling member for coupling the at least one permeable expandable container and the at least one substance holding container to form a single unit;

whereby when the device is positioned in situ, bodily fluid permeates the at least one permeable expandable container causing the at least one expandable particle contained therein to swell and the at least one permeable expandable container to expand from the first dimension to the second dimension so that the device remains in situ for a period of time sufficient to achieve the desired delivery of the substance.

9. The device as claimed in claim 8, further comprising at least one substance carrying particle contained within the substance-holding container, whereby the substance is releasably associated with the at least one substance carrying particle.

10. The device as claimed in claim 8, whereby the substance-holding container comprises a non-permeable material.

11. The device as claimed in claim 8, further comprising a carrier, whereby the at least one permeable expandable container and the at least one substance-holding container are coupled to the carrier by the at least one coupling member to form the single unit.

12. The device as claimed in claim 8, whereby the coupling member is selected from the group comprising an absorbable biodegradable surgical suture, a piece of biodegradable medical gauze, an absorbable net-like nanostructure, biocompatible glue or combinations thereof.

13. The device as claimed in claim 11, the carrier having a compartment, whereby the carrier further comprises at least one decoupler located in the compartment for decoupling the at least one permeable expandable container, the at least one substance-holding container, or both, from the carrier.

14. A device for delivering a substance in situ in a body, comprising:

(a) a carrier having at least one interior compartment

(b) at least one permeable expandable container having a first dimension and a second dimension releasably attached to the carrier by a coupling member; and

(c) at least one expandable particle comprising a swellable material contained within the container and capable of expanding when contacted with a fluid;

whereby when the device is positioned in situ, bodily fluid permeates the at least one permeable expandable container causing the at least one expandable particle contained therein to swell and the at least one permeable expandable container to expand from the first dimension to the second dimension so that the device remains in situ for a period of time sufficient to achieve the desired delivery of the substance.

15. The device as claimed in claim 14, further comprising at least one substance carrying particle, whereby the substance is releasably associated with the at least one substance carrying particle, said at least one substance carrying particle being located in either an interior compartment of the carrier, the at least one container, or both.

16. The device as claimed in claim 15, whereby the substance carrying particle comprises a dissolvable material.

18. The device as claimed in claim 14, the carrier having a second compartment, whereby the carrier further comprises at least one decoupler located in the second compartment for decoupling the at least one permeable expandable container from the carrier.