MYOCARDIUM CONDITIONING USING MYOCARDIAL AND PARASYMPATHETIC STIMULATION
First Claim
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1. A system, comprising:
- a neural stimulator adapted to generate a neural stimulation signal;
a pulse generator adapted to generate a pacing signal to provide myocardium pacing; and
a controller adapted to control the neural stimulator and the pulse generator to provide a cardioprotective conditioning therapy, the conditioning therapy including neural stimulation to elicit a parasympathetic response and myocardium pacing,wherein to provide the myocardium pacing for the cardioprotective conditioning therapy, the controller is configured to control the pulse generator to deliver a programmed myocardial pacing sequence,wherein the controller is configured to initiate and time a sequence of myocardial pacing pulses for the programmed myocardial pacing sequence,wherein the sequence of myocardial pacing pulses includes alternating pacing periods with a programmed pacing duration and non-pacing periods with a programmed non-pacing duration,wherein each pacing period in the programmed myocardial pacing sequence includes the timed sequence of myocardial pacing pulses delivered to a myocardium for the duration of each of the pacing periods, andwherein myocardial pacing pulses are not delivered during each of the non-pacing periods.
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Abstract
Various system embodiments comprise a neural stimulator, a pulse generator, and a controller. The neural stimulator is adapted to generate a neural stimulation signal. The pulse generator is adapted to generate a pacing signal to provide myocardium pacing. The controller is adapted to control the neural stimulator and the pulse generator to provide a cardioprotective conditioning therapy. The conditioning therapy includes neural stimulation to elicit a parasympathetic response and myocardium pacing. Other aspects and embodiments are provided herein.
48 Citations
20 Claims
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1. A system, comprising:
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a neural stimulator adapted to generate a neural stimulation signal; a pulse generator adapted to generate a pacing signal to provide myocardium pacing; and a controller adapted to control the neural stimulator and the pulse generator to provide a cardioprotective conditioning therapy, the conditioning therapy including neural stimulation to elicit a parasympathetic response and myocardium pacing, wherein to provide the myocardium pacing for the cardioprotective conditioning therapy, the controller is configured to control the pulse generator to deliver a programmed myocardial pacing sequence, wherein the controller is configured to initiate and time a sequence of myocardial pacing pulses for the programmed myocardial pacing sequence, wherein the sequence of myocardial pacing pulses includes alternating pacing periods with a programmed pacing duration and non-pacing periods with a programmed non-pacing duration, wherein each pacing period in the programmed myocardial pacing sequence includes the timed sequence of myocardial pacing pulses delivered to a myocardium for the duration of each of the pacing periods, and wherein myocardial pacing pulses are not delivered during each of the non-pacing periods. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification