METHOD AND SYSTEM FOR RAPID PHASE LUMINESCENSE SPECTROSCOPY ANALYSIS
First Claim
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1. A system for analyzing a pharmaceutical composition having at least one constituent, comprising:
- a luminescence sensor having an integral low current light source, said sensor being adapted to direct a plurality of radiation pulses to the pharmaceutical composition and detect luminescence emitted from the constituent, said sensor being further adapted to provide at least one luminescence signal representing said detected luminescence; and
control means in communication with said sensor for controlling said sensor and analyzing said luminescence signal.
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Abstract
A system for use in analyzing a pharmaceutical composition having multiple constituents comprising a luminescence sensor, the sensor being adapted to direct a plurality of radiation pulses to the pharmaceutical composition and detect luminescence emitted from each composition constituent as a function of time, the sensor being further adapted to provide at least one luminescence signal corresponding to the detected luminescence of each constituent, and control means in communication with the sensor for controlling the sensor and analyzing the luminescence signal.
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Citations
22 Claims
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1. A system for analyzing a pharmaceutical composition having at least one constituent, comprising:
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a luminescence sensor having an integral low current light source, said sensor being adapted to direct a plurality of radiation pulses to the pharmaceutical composition and detect luminescence emitted from the constituent, said sensor being further adapted to provide at least one luminescence signal representing said detected luminescence; and control means in communication with said sensor for controlling said sensor and analyzing said luminescence signal. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A system for processing a pharmaceutical composition having at least one constituent, comprising:
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a processing apparatus configured to process the pharmaceutical composition; and a luminescence detection system operatively associated with said processing apparatus, said detection system including at least one luminescence sensor having an integral low current light source, said sensor being adapted to direct a plurality of radiation pulses to the pharmaceutical composition and detect luminescence emitted from the constituent, said sensor being further adapted to provide at least one luminescence signal representing said detected luminescence, and control means in communication with said sensor for controlling said sensor and analyzing said luminescence signal. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. A method of in-situ analysis of a pharmaceutical composition during processing, the pharmaceutical composition having at least one constituent that emits luminescence in response to applied radiation, the method comprising the steps of:
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providing a processing apparatus configured to process the pharmaceutical composition; providing a luminescence detection system operatively associated with said processing apparatus, said detection system including at least one luminescence sensor having an integral low current light source, said sensor being adapted and positioned to direct a plurality of radiation pulses to the pharmaceutical composition and detect the luminescence emitted from the constituent, said sensor being further adapted to provide at least one luminescence signal representing said detected luminescence, and control means in communication with said sensor for controlling said sensor; illuminating the pharmaceutical composition with at least a respective one of said plurality of radiation pulses; detecting said luminescence emitted from the pharmaceutical composition constituent; and determining at least one characteristic of the pharmaceutical composition from said detected luminescence.
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Specification