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DERMAL MICRO-ORGANS, METHODS AND APPARATUSES FOR PRODUCING AND USING THE SAME

  • US 20100150878A1
  • Filed: 10/01/2009
  • Published: 06/17/2010
  • Est. Priority Date: 11/05/2001
  • Status: Active Grant
First Claim
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1. A genetically modified dermal micro-organ expressing at least one recombinant gene product, said dermal micro-organ comprising a plurality of dermal components, which retain the micro-architecture and three-dimensional structure of the dermal tissue from which they are derived, having dimensions selected so as to enable passive diffusion of adequate nutrients and gases to cells of said dermal micro-organ and diffusion of cellular waste out of said cells so as to minimize cellular toxicity and concomitant death due to insufficient nutrition and accumulation of waste in said dermal micro-organ, wherein at least some of said cells express at least a portion of at least one recombinant gene product, and wherein said recombinant gene product is Factor VIII.

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