Method of Producing Lymphocytes
First Claim
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1. A method for preparing lymphocytes characterized in that the method comprises the step of carrying out expansion in the presence of (a) fibronectin, a fragment thereof or a mixture thereof, (b) a CD3 ligand, and (c) a CD28 ligand.
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Abstract
A method for preparing lymphocytes characterized in that the method comprises the step of carrying out expansion in the presence of (a) fibronectin, a fragment thereof or a mixture thereof, (b) a CD3 ligand, and (c) a CD28 ligand.
20 Citations
15 Claims
- 1. A method for preparing lymphocytes characterized in that the method comprises the step of carrying out expansion in the presence of (a) fibronectin, a fragment thereof or a mixture thereof, (b) a CD3 ligand, and (c) a CD28 ligand.
- 12. A method for preparing a solid phase to which at least one selected from the group consisting of an anti-CD3 antibody, an anti-CD28 antibody, fibronectin and a fragment thereof is immobilized, characterized in that the solid phase is contacted with at least one selected from the group consisting of an anti-CD3 antibody, an anti-CD28 antibody, fibronectin and a fragment thereof under an acidic condition.
- 14. A solid phase to which (a) fibronectin, a fragment thereof or a mixture thereof, (b) a CD3 ligand, and (c) a CD28 ligand are immobilized.
Specification