Dry Powder Fibrin Sealant

• US 20100150900A1
• Filed: 12/12/2009
• Published: 06/17/2010
• Est. Priority Date: 12/12/2008
• Status: Active Grant

• Current Assignee: Mallinckrodt Pharma Ip Trading DAC (Mallinckrodt plc), Quadrant Drug Delivery Limited (Vectura Group Ltd.)
• Original Assignee: Mallinckrodt Pharma Ip Trading DAC (Mallinckrodt plc)
• Inventors: Whitfield, Nicola, Koopman, Jaap, Grimbergen, Jos
• Granted Patent: US 9,827,205 B2
• Time in Patent Office: Days
• US Class Current: 424/94.640
• CPC Class Codes: A61K 38/363 Fibrinogen
• CPC Class Codes: A61K 38/4833 Thrombin (3.4.21.5)
• CPC Class Codes: A61K 41/17 by ultraviolet [UV] or infrared [IR] light, X-rays or gamma rays
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/1623 Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
• CPC Class Codes: A61K 9/4858 Organic compounds
• CPC Class Codes: A61K 9/5084 Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs tablets containing such a mixture A61K9/2077
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: C12Y 304/21005 Thrombin (3.4.21.5)

Abstract

The invention provides a composition comprising a mixture of first microparticles that comprise fibrinogen and trehalose, and second microparticles that comprise thrombin and trehalose. The invention further provides methods for treating wounds by administering the novel microparticle composition.

Claims

1. A composition, comprising a mixture of first microparticles that comprise fibrinogen and trehalose, and second microparticles that comprise thrombin and trehalose.

2. The composition, as claimed in claim 1, wherein said first microparticles contain 0.5 to 20% w/w fibrinogen.

3. The composition, as claimed in claim 1, wherein said second microparticles comprise 10 to 20,000 IU/g thrombin.

4. The composition, as claimed in claim 3, wherein said second microparticles comprise 25 to 1,000 IU/g thrombin.

5. A method of treating a wound, comprising administering to the wound an effective amount of the composition as defined in claim 1.

6. The method, as claimed in claim 5, which additionally comprises applying pressure immediately after said administering.