Determining nutrients for animals through gene expression
First Claim
1. A method of identifying a biologically active nutrient for an individual animal having a genotype, comprising:
- (a) using a “
reference”
dataset containing functional genomic profiles of biological samples of the genotypes of different animals of the species, the different animals being healthy animals;
(b) selecting a “
target”
dataset containing the functional genomic profile of biological samples of the genotypes of different animals, the different animals being unhealthy animals;
(c) using a “
biologically active nutrient”
dataset comprising different effects of biologically active nutritional components on functional genomic profiles of the different animals of different genotypes from those of the target group (b), the different genotypes being differently responsive to the same biologically active nutritional components;
(d) having the reference dataset or target dataset include an individual animal for which the biolologically active nutrient is to be identified; and
(e) relating at least one of the “
reference”
or “
target group”
datasets with the “
biologically active nutrient”
dataset to identify a biologically active nutrient for the selected animal genotype to prevent, treat, control, or modulate a state of physiological homeostasis or pathophysiological condition of the individual animal in the reference dataset or target group.
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Abstract
Genetic information of DNA polymorphism, the functional genomic profile and the different response of an animal to a biologically active nutrient are used to identify the biologically active nutrient composition of the diet for an animal. The response to a nutrient exposure is dynamic since it depends upon the polymorphism of nutritionally inducible genes (as SNPs) that can lead to a different effect of the same nutrient in animals having different genotypes. The assessment of the biologically active nutrient composition of the diet arises from using reference data relating to normal healthy animals with different genotypes, target data relating to unhealthy animals with different genotypes, and nutritional data relating to a different effect of biologically active nutritional compounds in animals with different genotypes. Analysis is affected by relating gene, protein or metabolite expression.
33 Citations
20 Claims
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1. A method of identifying a biologically active nutrient for an individual animal having a genotype, comprising:
-
(a) using a “
reference”
dataset containing functional genomic profiles of biological samples of the genotypes of different animals of the species, the different animals being healthy animals;(b) selecting a “
target”
dataset containing the functional genomic profile of biological samples of the genotypes of different animals, the different animals being unhealthy animals;(c) using a “
biologically active nutrient”
dataset comprising different effects of biologically active nutritional components on functional genomic profiles of the different animals of different genotypes from those of the target group (b), the different genotypes being differently responsive to the same biologically active nutritional components;(d) having the reference dataset or target dataset include an individual animal for which the biolologically active nutrient is to be identified; and (e) relating at least one of the “
reference”
or “
target group”
datasets with the “
biologically active nutrient”
dataset to identify a biologically active nutrient for the selected animal genotype to prevent, treat, control, or modulate a state of physiological homeostasis or pathophysiological condition of the individual animal in the reference dataset or target group. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 18, 19)
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17. A method of identifying a biologically active nutrient for animals, comprising:
-
(a) using a “
reference”
dataset containing functional genomic profiles of biological samples of the genotypes of different animals of the species, the different animals being healthy animals;(b) selecting a “
target group”
dataset containing the functional genomic profile of biological samples of the genotypes of different animals, the animals being unhealthy animals;(c) using a “
biologically active nutrient”
dataset comprising different effects of biologically active nutritional components on functional genomic profiles of the different animals of different genotypes from those of the target group (b), the different genotypes being differently responsive to the same biologically active nutritional components;(d) having the reference group or target group include the animals; and (e) relating at least one of the “
reference”
or “
target group”
datasets with the “
biologically active nutrient”
dataset to identify a biologically active nutrient for the selected animal genotypes to prevent, treat, control, or modulate a state of physiological homeostasis or patho-physiological condition of the animal in the reference dataset or target group, and analyzing the gene or protein expression or the metabolite expression in the biological samples of the target dataset. - View Dependent Claims (20)
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Specification