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GENETIC MARKERS FOR SCHIZOPHRENIA AND BIPOLAR DISORDER

  • US 20100151461A1
  • Filed: 12/22/2008
  • Published: 06/17/2010
  • Est. Priority Date: 12/24/2007
  • Status: Active Grant
First Claim
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1. A method of determining a human subject'"'"'s risk of developing schizophrenia (SZ) or bipolar disorder (BD), the method comprising:

  • obtaining a test haplotype for the subject by determining the genotype for one or more test markers in the HPCAL1 gene between and including SNPs rs4668676 (SEQ ID NO;

    1) and rs12692407 (SEQ ID NO;

    11), or in the SV2C gene between and including SNPs rs889189 (SEQ ID NO;

         12) and rs31244 (SEQ ID NO;

    19), wherein the one or more test markers are selected from the group consisting of;

    rs4668676 (SEQ ID NO;

    1) or a marker in linkage disequilibrium therewith;

    rs6714483 (SEQ ID NO;

    2) or a marker in linkage disequilibrium therewith;

    rs17882379 (SEQ ID NO;

    3) or a marker in linkage disequilibrium therewith;

    rs6755271 (SEQ ID NO;

    4) or a marker in linkage disequilibrium therewith;

    rs887973 (SEQ ID NO;

    5) or a marker in linkage disequilibrium therewith;

    rs11893459 (SEQ ID NO;

    6) or a marker in linkage disequilibrium therewith;

    rs2270299 (SEQ ID NO;

    7) or a marker in linkage disequilibrium therewith;

    rs1808315 (SEQ ID NO;

    8) or a marker in linkage disequilibrium therewith;

    rs11694643 (SEQ ID NO;

    9) or a marker in linkage disequilibrium therewith;

    rs3732120 (SEQ ID NO;

    10) or a marker in linkage disequilibrium therewith;

    rs12692407 (SEQ ID NO;

    10) or a marker in linkage disequilibrium therewith;

    rs889189 ((SEQ ID NO;

    11) or a marker in linkage disequilibrium therewith;

    rs736005 (SEQ ID NO;

    12) or a marker in linkage disequilibrium therewith;

    rs6453211 (SEQ ID NO;

    13) or a marker in linkage disequilibrium therewith;

    rs4704298 (SEQ ID NO;

    14) or a marker in linkage disequilibrium therewith;

    rs1501926 (SEQ ID NO;

    15) or a marker in linkage disequilibrium therewith;

    rs11960621 (SEQ ID NO;

    17) or a marker in linkage disequilibrium therewith;

    rs2270927 (SEQ ID NO;

    18) or a marker in linkage disequilibrium therewith; and

    rs31244 (SEQ ID NO;

    19) or a marker in linkage disequilibrium therewith;

    wherein the test haplotype indicates the subject'"'"'s risk of developing SZ or BD.

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