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METHODS AND COMPOSITIONS FOR LOCATING SNP HETEROZYGOSITY FOR ALLELE SPECIFIC DIAGNOSIS AND THERAPY

  • US 20100151470A1
  • Filed: 10/30/2009
  • Published: 06/17/2010
  • Est. Priority Date: 05/01/2007
  • Status: Abandoned Application
First Claim
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1. A method for identifying the association between a disease-associated mutation and single nucleotide polymorphism (SNP) within a nucleic acid region comprising,obtaining a linear derivative of the nucleic acid region wherein the region comprises at least one SNP associated with the region,connecting the ends of the linear derivative to form a circular species in which the disease-associated mutation and SNP are positioned in closer proximity than the naturally-occurring disease associated mutation and SNP,producing at least a portion of the circular species containing the disease-associated mutation and SNP and,detecting the presence of the SNP and disease associated mutation thereby identifying their association within the same nucleic acid region.

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