METHOD OF DETECTION OF BIOANALYTES BY ACOUSTO-MECHANICAL DETECTION SYSTEMS COMPRISING THE ADDITION OF LIPOSOMES
First Claim
1. A method of detecting a target biological analyte, the method comprising:
- providing a system comprising an acousto-mechanical device comprising a detection surface with a capture agent located on the detection surface, wherein the capture agent is capable of selectively attaching the target biological analyte to the detection surface;
contacting the detection surface of the acousto-mechanical device with a sample material that may contain the target biological analyte;
selectively attaching the target biological analyte to the detection surface;
contacting the target biological analyte and/or detection surface with a liposome; and
operating the acousto-mechanical device to detect the attached target biological analyte while the detection surface is submersed in liquid.
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Abstract
Methods for detecting target biological analytes within sample material using acousto-mechanical energy generated by a sensor are disclosed. The acousto-mechanical energy may be provided using an acousto-mechanical sensor, e.g., a surface acoustic wave sensor such as, e.g., a shear horizontal surface acoustic wave sensor (e.g., a LSH-SAW sensor). The detection of the target biological analytes in sample material are enhanced by contacting the target biological analyte and/or the sensor surface with liposomes that amplify the sensor sensitivity by (1) modifying the rheological properties of the fluid near the sensor surface; (2) changing the mass attached to the surface; and/or (3) modifying the dielectric properties of the fluid near the sensor surface, the sensor surface itself and/or any intervening layers on the sensor surface.
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Citations
16 Claims
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1. A method of detecting a target biological analyte, the method comprising:
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providing a system comprising an acousto-mechanical device comprising a detection surface with a capture agent located on the detection surface, wherein the capture agent is capable of selectively attaching the target biological analyte to the detection surface; contacting the detection surface of the acousto-mechanical device with a sample material that may contain the target biological analyte; selectively attaching the target biological analyte to the detection surface; contacting the target biological analyte and/or detection surface with a liposome; and operating the acousto-mechanical device to detect the attached target biological analyte while the detection surface is submersed in liquid. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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Specification