SOLUTIONS FOR OPHTHALMIC LENSES CONTAINING AT LEAST ONE SILICONE CONTAINING COMPONENT

• US 20100152084A1
• Filed: 02/22/2010
• Published: 06/17/2010
• Est. Priority Date: 09/06/2002
• Status: Abandoned Application

• Current Assignee: Johnson & Johnson Vision Care Incorporated (Johnson & Johnson)
• Original Assignee: Johnson & Johnson Vision Care Incorporated (Johnson & Johnson)
• Inventors: Alvarez-Carrigan, Nayiby, Brown-Skrobot, Susan, Pall, Brian, Neely, Frank, Rathore, Osman, Meyers, Ann-Marie Wong
• Application Number:
  US12/709,811
• Publication Number:
  US 20100152084A1
• Time in Patent Office: Days
• US Class Current: 510/112
• CPC Class Codes: A61L 12/08 using chemical substances
• CPC Class Codes: A61L 12/088 Heavy metals
• CPC Class Codes: B65B 25/008 packaging of contact lenses
• CPC Class Codes: C11D 3/0078 Compositions for cleaning contact lenses, spectacles or lenses
• CPC Class Codes: C11D 3/046 Salts
• CPC Class Codes: C11D 3/06 Phosphates, including polyphosphates
• CPC Class Codes: C11D 3/2075 Carboxylic acids-salts thereof
• CPC Class Codes: C11D 3/2086 Hydroxy carboxylic acids-salts thereof
• CPC Class Codes: C11D 3/222 Natural or synthetic polysaccharides, e.g. cellulose, starch, gum, alginic acid or cyclodextrin
• CPC Class Codes: C11D 3/3707 Polyethers, e.g. polyalkyleneoxides
• CPC Class Codes: C11D 3/3773 in liquid compositions
• CPC Class Codes: G02B 1/043 Contact lenses

Abstract

The present invention relates to a method for reducing the occurrence of superficial punctate staining comprising the step of packaging, storing or contacting an uncoated ophthalmic lens comprising at least one polymeric wetting agent and polymer units derived from at least one silicone containing component in a solution comprising an osmolality of about 220 mOsm/kg or greater.

Claims

1. An article comprising a solution having an osmolality of about 220 mOsm/kg or greater in contact with an uncoated ophthalmic lens comprising polymeric units derived from at least one silicone containing component.

2. The article of claim 1 wherein said solution has an osmolality of about 230 mOsm/kg or greater.

3. The article of claim 1 wherein said solution has a conductivity of at least about 4 mS/cm or greater.

4. The article of claim 1 wherein said solution has a conductivity of at least about 5 mS/cm or greater.

5. The article of claim 1 wherein said solution comprises at least one ionic salt, non-ionic salt or a mixture thereof.

6. The article of claim 5 wherein said ionic salt is selected from the group consisting of sodium chloride, sodium sulfate, sodium acetate, sodium citrate, sodium borate, sodium phosphate, sodium lactate, sodium hydrogenphosphate, sodium dihydrogenphosphate, potassium chloride, potassium sulfate, potassium acetate, potassium citrate, potassium borate, potassium phosphate, potassium hydrogenphosphate, potassium dihydrogenphosphate, calcium chloride, calcium sulfate, calcium acetate, calcium citrate, calcium borate, calcium phosphate, calcium lactate, calcium hydrogenphosphate, calcium dihydrogenphosphate, magnesium chloride, magnesium sulfate, magnesium acetate, magnesium citrate, magnesium borate, magnesium phosphate, magnesium lactate, magnesium hydrogenphosphate, magnesium dihydrogenphosphate and mixtures thereof.

7. The article of claim 5 wherein said non-ionic salt is selected from the group consisting of polyethylene glycols, polyhydroxy compounds, polyether compounds, sugars, polyvinylamides, dextrans, cyclodextrans and mixtures thereof.

8. The article of claim 5 wherein said ionic salt is selected from the group consisting of sodium chloride, sodium sulfate, sodium borate and mixtures thereof.

9. The article of claim 1, 6 or 7 wherein said solution comprises saline solutions, buffered solutions and buffered saline solutions.

10. The article of claim 7, wherein said salt is present in an amount between about 0.01 to about 5.0 weight %

11. The article of claim 7, wherein said salt is present in an amount between about 0.1 to about 3.0 weight %

12. The article of claim 1 wherein said ophthalmic lens further comprises at least one polymeric wetting agent.

13. The article of claim 12 wherein said polymeric internal wetting agent is selected from the group consisting of polyamides, polylactones, polyimides, polylactams and functionalized polyamides, polylactones, polyimides, polylactams, hydrophilic Prepolymers and mixtures thereof.

14. The article of claim 12 wherein said polymeric internal wetting agent is selected from the group consisting of homopolymers and copolymers comprising N-vinylpyrrolidone, N-vinyl-N-methylacetamide, (meth)acrylic acid, N,N-dimethylacrylamide and mixtures thereof.

15. The article of claim 1 wherein said lens further comprises at least one antimicrobial metal salt.

16. The article of claim 1 wherein said solution is a packaging solution.

17. The article of claim 1 wherein said solution is a storage solution.

18. The article of claim 1 wherein said solution is a cleaning solution.

19. The article of claim 1 further comprising a package comprising a reservoir containing said solution and said lens immersed in said solution.

20. A method for reducing the occurrence of superficial punctate staining comprising the step of packaging, storing or contacting an uncoated ophthalmic lens comprising polymer units derived from at least one silicone containing component in a solution comprising an osmolality of about 220 mOsm/kg or greater.

21. The method of claim 20 wherein the occurrence of superficial punctate staining is less than about 50%.

22. The method of claim 20 wherein the occurrence of superficial punctate staining is less than about 30%.

23. The method of claim 20 wherein the occurrence of superficial punctate staining is less than about 10%.

24. The method of claim 20 wherein said solution has an osmolality of about 230 mOsm/kg or greater.

25. The method of claim 20 wherein said solution has a conductivity of at least about 4 mS/cm or greater.

26. The method of claim 20 wherein said solution has a conductivity of at least about 5 mS/cm or greater

27. The method of claim 20 wherein said solution comprises at least one ionic salt, non-ionic salt or a mixture thereof.

28. The method of claim 27 wherein said ionic salt is selected from the group consisting of sodium chloride, sodium sulfate, sodium acetate, sodium citrate, sodium borate, sodium phosphate, sodium lactate, sodium hydrogenphosphate, sodium dihydrogenphosphate, potassium chloride, potassium sulfate, potassium acetate, potassium citrate, potassium borate, potassium phosphate, potassium hydrogenphosphate, potassium dihydrogenphosphate, calcium chloride, calcium sulfate, calcium acetate, calcium citrate, calcium borate, calcium phosphate, calcium lactate, calcium hydrogenphosphate, calcium dihydrogenphosphate, magnesium chloride, magnesium sulfate, magnesium acetate, magnesium citrate, magnesium borate, magnesium phosphate, magnesium lactate, magnesium hydrogenphosphate, magnesium dihydrogenphosphate and mixtures thereof.

29. The method of claim 27 wherein said ionic salt is selected from the group consisting of sodium chloride, sodium sulfate, sodium borate and mixtures thereof.

30. The method of claim 27 wherein said ionic salt is selected from the group consisting of polyethylene glycols, polyhydroxy compounds, polyether compounds, sugars, polyvinylamides, dextrans, cyclodextrans and mixtures thereof.

31. The method of claim 27, wherein said salt is present in an amount between about 0.01 to about 5.0 weight %

32. The method of claim 20 wherein said solution comprises saline solutions, buffered solutions and buffered saline solutions.

33. The method of claim 27, wherein said salt is present in an amount between about 0.1 to about 3.0 weight %

34. The method of claim 20 where said ophthalmic lens further comprises at least one polymeric wetting agent.

35. The method of claim 34 wherein said polymeric internal wetting agent is selected from the group consisting of polyamides, polylactones, polyimides, polylactams and functionalized polyamides, polylactones, polyimides, polylactams, hydrophilic Prepolymers and mixtures thereof.

36. The method of claim 34 wherein said polymeric internal wetting agent is selected from the group consisting of homopolymers and copolymers comprising N-vinylpyrrolidone, N-vinyl-N-methylacetamide, (meth)acrylic acid, N,N-dimethylacrylamide and mixtures thereof.

37. The method of claim 20 wherein said lens further comprises at least one antimicrobial metal salt.

38. The method of claim 20 wherein said solution is a packaging solution.

39. A method for packaging, storing or cleaning a contact lens comprising the step of contacting said contact lens comprising at least one polymeric wetting agent and polymer units derived from at least one silicone containing component, with a solution comprising an osmolality of about 220 mOsm/kg or greater.