ZWITERIONIC TERPOLYMERS, METHOD OF MAKING AND USE ON MEDICAL DEVICES

• US 20100152402A1
• Filed: 02/23/2010
• Published: 06/17/2010
• Est. Priority Date: 11/21/2006
• Status: Active Grant

• Current Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories Incorporated)
• Inventors: Roorda, Wouter Erik, Pacetti, Stephen
• Granted Patent: US 8,431,665 B2
• Time in Patent Office: Days
• US Class Current: 526/277
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: C08F 220/1804 C4-(meth)acrylate, e.g. butyl (meth)acrylate, isobutyl (meth)acrylate or tert-butyl (meth)acrylate
• CPC Class Codes: C08F 220/281 and containing only one oxygen, e.g. furfuryl (meth)acrylate or 2-methoxyethyl (meth)acrylate
• CPC Class Codes: C08F 220/282 and containing two or more oxygen atoms
• CPC Class Codes: C08F 220/36 containing oxygen in addition to the carboxy oxygen , e.g. 2-N-morpholinoethyl (meth)acrylate or 2-isocyanatoethyl (meth)acrylate
• CPC Class Codes: C08F 230/02 containing phosphorus
• CPC Class Codes: C08L 33/14 of esters containing halogen, nitrogen, sulfur, or oxygen atoms in addition to the carboxy oxygen
• CPC Class Codes: C09D 133/14 of esters containing halogen, nitrogen, sulfur or oxygen atoms in addition to the carboxy oxygen

Abstract

Biocompatible terpolymers are manufactured to include a zwitterionic monomer, an alkoxy acrylate monomer, and a hydrophobic monomer.

Claims

1. A biocompatible polymer, comprising:

R₁, R₂, and R₄ are independently a hydrogen or methyl;

R₃ includes a zwitterion group, a linker being a chain of 2-12 carbon atoms, and an ester or amide attachment to the acryl or methacryl group;

R₅ is an ethyl or methyl;

R₆ is a straight chain, branched, unsaturated, or cyclic hydrocarbon of one to sixteen carbon atoms;

n is a mole fraction in a range from about 0.01 to about 0.75;

m is a mole fraction in a range from about 0.1 to about 0.99; and

o is a mole fraction in a range from about 0.1 to about 0.99.

2. A biocompatible polymer as in claim 1, in which the zwitterion group is selected from the group consisting of phosphorylcholine, phosphoryl ethanolamine, phosphatidyl ethanolamine, phosphoethanolamine, phosphatidyl serine, sulfobetaine and combinations thereof.

3. A biocompatible polymer as in claim 1, in which R₆ is selected from the group consisting of a methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, 2-ethyl-hexyl, n-hexyl, cyclohexyl, n-hexyl, isobornyl, or trimethylcyclohexyl, and combinations thereof.

4. A biocompatible polymer as in claim 1, in which R₅ is a methyl.

5. A biocompatible polymer as in claim 1, in which R₅ is an ethyl.

6. A biocompatible polymer as in claim 1, in which the glass transition temperature of the polymer when hydrated is in a range from about −

30°

C. to about 37°

C.

7. A biocompatible polymer as in claim 1, in which the glass transition temperature of the polymer when hydrated is in a range from about 0°

C. to about 37°

C.

8. A biocompatible polymer as in claim 1, in which the glass transition temperature of the polymer when dry is in a range from about −

30°

C. to about 100°

C.

9. A biocompatible polymer as in claim 1, in which the glass transition temperature of the polymer when dry is in a range from about 0°

C. to about 70°

C.

10. A biocompatible polymer as in claim 1, in which the number average molecular weight is in a range from about 20K to about 800K.

11. A biocompatible polymer as in claim 1, in which the number average molecular weight is in a range from about 100K to about 600K.

12. A biocompatible polymer as in claim 1, in which the number average molecular weight is in a range from about 2K to about 200K.