Assessment of Preload Dependence and Fluid Responsiveness

• US 20100152592A1
• Filed: 12/23/2009
• Published: 06/17/2010
• Est. Priority Date: 08/13/2007
• Status: Abandoned Application

• Current Assignee: Edwards Lifesciences Corporation
• Original Assignee: Edwards Lifesciences Corporation
• Inventors: Derderian, Lina, Roteliuk, Luchy, Hatib, Feras
• Application Number:
  US12/646,812
• Publication Number:
  US 20100152592A1
• Time in Patent Office: Days
• US Class Current: 600/485
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/02108 from analysis of pulse wave characteristics
• CPC Class Codes: A61B 5/726 using Wavelet transforms

Abstract

Methods for determining a cardiovascular parameter reflecting fluid or volume changes and for detecting arrhythmia are disclosed. These methods involve receiving a waveform dataset corresponding to an arterial blood pressure, pulseox, Doppler ultrasound or bioimpedance signal and analyzing the waveform to detect irregular cardiac cycles. Irregular cardiac cycles are detected, for example, by comparing parameters of individual cardiac cycles to the parameters of other or average cardiac cycles. If any irregular cardiac cycles are present, their effect is compensated for to form a modified waveform dataset. Once any irregular cardiac cycles are compensated for, a cardiovascular parameter reflecting fluid or volume changes using the modified waveform dataset is calculated. In the method for determining arrhythmia, if the number of irregular cardiac cycles exceeds a predetermined arrhythmia threshold, a user such as a medical professional is notified.

Claims

1. A method of determining a cardiovascular parameter reflecting preload dependence, fluid responsiveness or, volume responsiveness comprising:

receiving a waveform dataset corresponding to an arterial blood pressure, or a signal proportional to, or derived from, the arterial blood pressure signal;

detecting an irregular cardiac cycle;

compensating for the effect of the irregular cardiac cycle to form a modified waveform dataset; and

calculating a cardiovascular parameter reflecting preload dependence, fluid responsiveness, or volume responsiveness using the modified waveform dataset.

2. The method of claim 1, wherein detecting the irregular cardiac cycle comprises:

identifying an individual cardiac cycle in the waveform dataset;

comparing one or more parameters of the individual cardiac cycle to one or more parameters of a control cardiac cycle; and

identifying the individual cardiac cycle as an irregular cardiac cycle if the one or more parameters of the individual cardiac cycle differs from the one or more parameters of the control cardiac cycle by a predetermined threshold amount.

9. The method of claim 2, wherein the predetermined threshold amount is 1% or more.

10. The method of claim 1, wherein the irregular cardiac cycle is a premature ventricular contraction, a premature atrial contraction, a cardiac cycle caused by arrhythmia, a cardiac cycle caused by atrial fibrillation, a patient artifact, or noise from external interference.

12. The method of claim 1, wherein compensating for the effect of the irregular cardiac cycle includes removing the irregular cardiac cycle from the waveform, smoothing the irregular cardiac cycle, filtering the irregular cardiac cycle, attenuating the irregular cardiac signal, or replacing the irregular cardiac cycle with an estimated cardiac cycle.

13. The method of claim 2, wherein the control cardiac cycle is a cardiac cycle immediately preceding the individual cardiac cycle.

15. The method of claim 2, wherein the control cardiac cycle is a cardiac cycle immediately following the individual cardiac cycle.

29. The method of claim 1, wherein the cardiovascular parameter is left ventricular stroke volume variation, pulse pressure variation, or systolic pressure variation.

32. The method of claim 1, further comprising indicating the position of the irregular cardiac cycle on a graphical user interface.

33. The method of claim 1, further comprising when an irregular cardiac cycle is detected indicating that an irregular cardiac cycle is present on a graphical user interface.

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37. A method of detecting arrhythmia comprising:

receiving a waveform dataset corresponding to an arterial blood pressure, or a signal proportional to, or derived from the arterial blood pressure signal;

detecting irregular cardiac cycles; and

notifying a user if the number of irregular cardiac cycles exceeds a predetermined arrhythmia threshold.

38. The method of claim 37, wherein the predetermined arrhythmia threshold is 30% of a total number of cardiac cycles.

42. The method of claim 37, wherein the irregular cardiac cycle is a premature ventricular contraction, a premature atrial contraction, a cardiac cycle caused by arrhythmia, a cardiac cycle caused by atrial fibrillation, or a patient artifact.

44. The method of claim 37, wherein detecting irregular cardiac cycles comprises:

identifying individual cardiac cycles in the waveform dataset;

comparing one or more parameters of the individual cardiac cycles to one or more parameters of a control cardiac cycle; and

identifying the individual cardiac cycles as irregular cardiac cycles if the one or more parameters of the individual cardiac cycles differ from the one or more parameters of the control cardiac cycle by a selected parameter threshold.

51. The method of claim 44, wherein the predetermined threshold amount is 1% or more.

52. The method of claim 37, wherein detecting irregular cardiac cycles comprises:

identifying individual cardiac cycles in the waveform dataset;

detecting variability in one or more parameters of the individual cardiac cycles as compared to a control cardiac cycle; and

identifying the individual cardiac cycles as irregular cardiac cycles if a predetermined variability in the one or more parameters of the individual cardiac cycle is met.

59. The method of claim 52, wherein the predetermined variability is 1% or more.

62. The method of claim 44, wherein the control cardiac cycle is a cardiac cycle immediately preceding the individual cardiac cycle.

64. The method of claim 44, wherein the control cardiac cycle is a cardiac cycle immediately after the individual cardiac cycle.

78. The method of claim 37, wherein notifying a user comprises indicating arrhythmia on a graphical user interface.

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