Compositions for Delivery of Therapeutics and Other Materials
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Abstract
This disclosure relates to compositions for delivering agents to a subject, and in particular, to compositions for delivery of therapeutic agents or diagnostic agents in the presence or absence of targeting moieties. In part, this disclosure relates to compositions comprising a hydrophobic group with a first end and a second end, a first metal binding domain linked to the hydrophobic group, a metal ion capable of being chelated to the first metal binding domain, and an agent linked to a second metal binding domain capable of chelating to the metal ion.
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Citations
48 Claims
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1-26. -26. (canceled)
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27. A method of treatment or diagnosis of a subject in need of such treatment or diagnosis comprising administering a composition to the subject, the composition comprising:
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a first molecule comprising; a first hydrophobic group comprising a first metal binding domain (FMBD) at one end; a metal ion chelated to the FMBD; and an active agent comprising a second MBD (SMBD) coordinately bonded to said metal ion; and a second molecule comprising; a second hydrophobic group comprising a first and second end; and a first hydrophilic group comprising a first and second end, wherein the first end is covalently linked to the first end of the second hydrophobic group; wherein after administration of the composition to said patient, the active agent is released in a sustained manner. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48)
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44-1. The method of claim 27 wherein the route of administration is parenteral.
Specification