DRUG DELIVERY DEVICES FOR DELIVERY OF THERAPEUTIC AGENTS
First Claim
Patent Images
1. A drug delivery device comprising:
- a composition comprising an active agent; and
a non-bioabsorbable polymer structure enclosing the composition, the polymer structure comprising a mixture comprising a water-soluble polymer and a non-water-soluble polymer.
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Abstract
Drug delivery devices comprising a non-bioabsorbable polymer structure and a composition comprising an active agent have been discovered. The drug delivery devices may be used to treat ocular conditions, among other diseases and conditions. In addition, a method of treating an ocular condition has been discovered comprising implanting a drug delivery device which releases the active agent at a rate of
Q=0.001×N×C
wherein C is the topical effective concentration (in milligram/mL) of the active agent and N=0.01 to 0.5 for prostaglandins in their ester, amide, free acid or salt form, and N=0.5 to 5 for any active agent other than prostaglandins in their ester, amide, free acid or salt form.
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Citations
47 Claims
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1. A drug delivery device comprising:
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a composition comprising an active agent; and a non-bioabsorbable polymer structure enclosing the composition, the polymer structure comprising a mixture comprising a water-soluble polymer and a non-water-soluble polymer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 38, 39, 40)
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11. A drug delivery device comprising:
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a composition comprising an active agent; and a non-bioabsorbable polymer structure enclosing the composition, the polymer structure comprising an impermeable polymer through which the active agent does not permeate and a partially-bioerodible membrane through which the active agent permeates. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 41, 42, 43)
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23. A drug delivery device comprising:
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a composition comprising a single compressed pellet comprising an active agent with a solubility of greater than about 50 micrograms/mL in phosphate buffered saline at a neutral pH; and a non-bioabsorbable polymer structure enclosing the composition, the polymer structure comprising an impermeable polymer through which the active agent does not permeate and a rate-limiting water-permeable polymer through which the active agent permeates. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 44, 45, 46)
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- 35. A drug delivery device comprising a composition comprising an active agent at least partially encompassed by an impermeable membrane and a permeable membrane, wherein the permeable membrane controls release of the active agent episclerally over a period of time.
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47. A method of treating an ocular condition comprising implanting episclerally a drug delivery device comprising an active agent, wherein the active agent is released at a rate of
Q=0.001×- N×
Cwherein C is the topical effective concentration (in milligram/mL) of the active agent and N=0.01 to 0.5 for prostaglandins in their ester, amide, free acid or salt form, and N=0.5 to 5 for any active agent other than prostaglandins in their ester, amide, free acid or salt form.
- N×
Specification