SYSTEMICALLY AND LOCALLY ADMINISTERED CELLS FOR NEUROPATHIC PAIN
First Claim
1. A method of treating a subject having neuropathic pain, said method comprising administering to the subject a composition comprising a population of isolated umbilical cord tissue-derived cells such that neuropathic pain is treated.
1 Assignment
0 Petitions
Accused Products
Abstract
Methods for treating chronic pain, neuropathic pain or spasticity are provided. Some embodiments are to methods for treatment comprising administering cells obtained from human umbilical cord tissue, or administering pharmaceutical compositions comprising such cells or prepared from such cells. In some embodiments, administering the cells promotes repair and regeneration of nerves in the patient to decrease chronic pain, neuropathic pain or spasticity. Pharmaceutical compositions for use in the inventive methods, as well as kits for practicing the methods are also provided.
-
Citations
21 Claims
- 1. A method of treating a subject having neuropathic pain, said method comprising administering to the subject a composition comprising a population of isolated umbilical cord tissue-derived cells such that neuropathic pain is treated.
-
2. A method of treating a subject having neural spasticity, said method comprising administering to the subject a composition comprising a population of isolated umbilical cord tissue-derived cells such that neural spasticity is treated.
- 3. A method of treating a subject having neuropathic pain, said method comprising administering to the patient umbilical cord tissue-derived cells in an amount effective to treat neuropathic pain, wherein said cells are derived from human umbilical cord tissue substantially free of blood and are capable of self-renewal and expansion in culture.
- 13. A composition used for treating chronic pain, said composition comprising a population of umbilical cord tissue-derived cells.
-
14. A composition used for treating neuropathic pain, said composition comprising a population of umbilical cord tissue-derived cells.
-
15. A composition used for treating spasticity, said composition comprising a population of umbilical cord tissue-derived cells.
-
20. A kit used for treating chronic pain, neuropathic pain or spasticity, said kit comprising a population of umbilical cord tissue-derived cells, a pharmaceutically acceptable carrier and/or diluent and a hydrogel.
-
21. A kit used for treating chronic pain, neuropathic pain or spasticity, said kit comprising a population of hUTC cells, a pharmaceutically acceptable carrier and/or diluent and a collagen or fibrin-thrombin construct.
Specification