COLONIC PURGATIVE COMPOSITION WITH SOLUBLE BINDING AGENT
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Abstract
This invention relates to novel colonic purgative compositions in a solid dosage form, comprising at least one purgative and at least one soluble, or soluble, nonfermentable binder, such as polyethylene glycol. Further, this invention relates to methods of using the colonic purgative compositions. The present compositions and methods are designed to improve patient tolerance and compliance, while at the same time improving the quality of bowel cleansing. The formulations and methods of this invention are particularly useful to cleanse the bowel prior to diagnostic and surgical procedures and can also be employed in lower dosages as a laxative to promote elimination and/or to relieve constipation.
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Citations
53 Claims
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1-29. -29. (canceled)
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30. A method of making a colonic purgative formulation in a tablet form, comprising:
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heating a formulation comprising sodium phosphate and polyethylene glycol to the melting point of the polyethylene glycol; and compressing the formulation into a tablet. - View Dependent Claims (31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42)
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43. A method of making a colonic purgative tablet formulation, comprising:
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heating a formulation comprising 60%-90% sodium phosphate and 5% to 20% polyethylene glycol 8000; allowing the formulation to cool below 30°
C.; andcompressing the formulation into tablets. - View Dependent Claims (44, 45, 46, 47, 48, 49, 50, 51, 52, 53)
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Specification