ANTIMICROBIAL AGENTS, COMPOSITIONS AND PRODUCTS CONTAINING THE SAME, AND METHODS OF USING THE COMPOSITIONS AND PRODUCTS

• US 20100160454A1
• Filed: 11/10/2009
• Published: 06/24/2010
• Est. Priority Date: 12/22/2008
• Status: Abandoned Application

• Current Assignee: Eastman Chemical Company
• Original Assignee: Eastman Chemical Company
• Inventors: Watterson, Thelma Lee, Dobbs, Suzanne Winegar, McCaulley, James Allen, Oldfield, Terry Ann, Matosky, Andrew Joseph, Christian, Vicky Lynn, Seo, Kab Sik, Posey-Dowty, Jessica, Kinkade, Nancy
• Application Number:
  US12/615,639
• Publication Number:
  US 20100160454A1
• Time in Patent Office: Days
• US Class Current: 514/729
• CPC Class Codes: A01N 31/04 Oxygen or sulfur attached to an aliphatic side-chain of a carbocyclic ring system
• CPC Class Codes: A01N 31/06 Oxygen or sulfur directly attached to a cycloaliphatic ring system
• CPC Class Codes: A61K 2800/524 Preservatives
• CPC Class Codes: A61K 8/345 containing more than one hydroxy group
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 31/02 Local antiseptics
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61Q 1/10 for eyes, e.g. eyeliner, mascara
• CPC Class Codes: A61Q 15/00 Anti-perspirants or body deodorants deodorisation of air A61L9/00
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: C10L 1/1826 poly-hydroxy
• CPC Class Codes: C10L 1/19 Esters ester radical containing compounds; ester ethers; carbonic acid esters C10L1/1802, C10L1/1805, C10L1/1808, C10L1/1811, C10L1/1814, C10L1/1817 take precedence
• CPC Class Codes: C10L 10/00 Use of additives to fuels or fires for particular purposes additives for liquid carbonaceous fuels characterised by their chemical nature C10L1/10; using binders for briquetting solid fuels C10L5/10; using additives to improve the combustion of solid fuels C10L9/10
• CPC Class Codes: C10M 129/08 containing at least 2 hydroxy groups
• CPC Class Codes: C10M 2207/022 containing at least two hydroxy groups
• CPC Class Codes: C10M 2207/401 used as base material
• CPC Class Codes: C10N 2030/16 Antiseptic; (micro) biocidal or bactericidal
• CPC Class Codes: C10N 2040/04 Oil-bath; Gear-boxes; Automatic transmissions; Traction drives
• CPC Class Codes: C10N 2040/042 for automatic transmissions
• CPC Class Codes: C10N 2040/044 : for manual transmissions
• CPC Class Codes: C10N 2040/08 : Hydraulic fluids, e.g. brake-fluids
• CPC Class Codes: C11D 3/2051 : cyclic; polycyclic
• CPC Class Codes: C11D 3/48 : Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
• CPC Class Codes: D01F 1/103 : Agents inhibiting growth of microorganisms

Abstract

Antimicrobial agents, products and compositions incorporating the agents, and methods of using the compositions and products are provided. The antimicrobial agents comprise 1,2-cyclohexanedimethanol, 1,4-cyclohexanedimethanol, 2,2,4,4-tetramethyl-1,3-cyclobutanediol, or mixtures thereof. These agents have surprisingly been found to inhibit microbial growth at a much lower concentration than other glycols with known antimicrobial activity.

Claims

1. A method for reducing or inhibiting microbial growth in an aqueous composition comprising:

adding an antimicrobial agent selected from the group consisting of 1,2-cyclohexanedimethanol, 1,4-cyclohexanedimethanol, and 2,2,4,4-tetramethyl-1,3-cyclobutanediol to the composition.

2. The method according to claim 1, wherein the antimicrobial agent is added in an amount of about 1 to 5 weight percent, based on the total weight of the composition.

3. The method according to claim 1, wherein the antimicrobial agent is added in an amount of about 1 to 3 weight percent, based on the total weight of the composition.

4. The method according to claim 1, wherein the antimicrobial agent is 1,2-cyclohexanedimethanol.

5. The method according to claim 1, wherein the antimicrobial agent is 1,4-cyclohexanedimethanol.

6. The method according to claim 1, wherein the antimicrobial agent is 2,2,4,4-tetramethyl-1,3-cyclobutanediol.

7. The method according to claim 1, where the microbial growth is a biofilm.

8. The method according to claim 1, wherein the antimicrobial agent is added to the aqueous composition by contacting the aqueous composition with a solvent that is immiscible with water and that comprises the antimicrobial agent.

9. The method according to claim 1, wherein the aqueous composition comprises an organic compound selected from hydrocarbons, triglycerides, fatty acids, fatty acid alkyl esters, fatty alcohols, polyglycol ethers, alkyl glycol ethers, alkyl glycol esters, alkyl glycol ether esters, alkyl amines, alkyl amides, or mixtures thereof.

10. The method according to claim 9, wherein the organic compound and water in the aqueous composition are miscible.

11. The method according to claim 9, wherein the organic compound and water in the aqueous composition are in separate liquid phases, and the method reduces or inhibits microbial growth at the interface between the organic phase and the aqueous phase.

12. The method according to claim 9 or 11, wherein the organic compound is diesel, biodiesel, a mixture of diesel and biodiesel, aviation fuel, hydraulic oil, lubrication oil, vegetable oil, crude oil, transmission fluid, heating oil, or kerosene.

13. A method for providing residual antimicrobial activity to a surface, said method comprising:

topically applying a composition comprising about 1 to 5 weight percent of an antimicrobial agent selected from the group consisting of 1,2-cyclohexanedimethanol, 1,4-cyclohexanedimethanol, and 2,2,4,4-tetramethyl-1,3-cyclobutanediol to the surface; and

optionally removing any excess amounts of the product from the surface.

14. The method according to claim 13, wherein the surface has a biofilm before applying the product.

15. A method for preventing or treating a bacterial or fungal infection on a mammalian surface, said method comprising:

topically applying a composition comprising about 1 to 5 weight percent of an antimicrobial agent selected from the group consisting of 1,2-cyclohexanedimethanol, 1,4-cyclohexanedimethanol, and 2,2,4,4-tetramethyl-1,3-cyclobutanediol to the mammalian surface; and

optionally removing any excess amounts of the product from the mammalian surface.

16. A method for preventing or reducing odor from the presence of bacteria or fungi on a mammalian surface, said method comprising:

topically applying a composition comprising about 1 to 5 weight percent of an antimicrobial agent selected from the group consisting of 1,2-cyclohexanedimethanol, 1,4-cyclohexanedimethanol, and 2,2,4,4-tetramethyl-1,3-cyclobutanediol to the mammalian surface; and

optionally removing any excess amounts of the product from the mammalian surface.

17. A method for providing antimicrobial activity to a film, fiber, molded or extruded article, or composite material made of fibers, polymers, adhesives, and/or gypsum;

said method comprising;

incorporating an antimicrobial agent selected from the group consisting of 1,2-cyclohexanedimethanol, 1,4-cyclohexanedimethanol, and 2,2,4,4-tetramethyl-1,3-cyclobutanediol into the film, fiber, molded or extruded article, or composite material during its manufacturing process.

18. The method according to claim 17, which prevents a biofilm from forming on a surface of the film, fiber, molded or extruded article, or composite material.

19. The method according to claim 17, wherein the antimicrobial agent is incorporated in an amount of about 1 to 5 weight percent, based on the total weight of the film, fiber, molded or extruded article, or composite material.

20. The method according to claim 17, wherein the antimicrobial agent is incorporated in an amount of about 1 to 3 weight percent, based on the total weight of the film, fiber, molded or extruded article, or composite material.

21. The method according to claim 17, wherein the antimicrobial agent is 1,2-cyclohexanedimethanol.

22. The method according to claim 17, wherein the antimicrobial agent is 1,4-cyclohexanedimethanol.

23. The method according to claim 17, wherein the antimicrobial agent is 2,2,4,4-tetramethyl-1,3-cyclobutanediol.