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CYCLIC AMIDE DERIVATIVE, AND ITS PRODUCTION AND USE

  • US 20100160629A1
  • Filed: 03/02/2010
  • Published: 06/24/2010
  • Est. Priority Date: 05/21/2004
  • Status: Active Grant
First Claim
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1. A compound represented by the formula (I):

  • wherein R1 represents a cyclic hydrocarbon group which may be optionally substituted or a heterocyclic group which may be optionally substituted,W represents a bond or a divalent chain hydrocarbon group which may be optionally substituted,a represents 0, 1, or 2,X1 represents a lower alkylene which may be optionally substituted or a lower alkenylene which may be optionally substituted,Y1 represents —

    C(O)—

    , —

    S(O)—

    or —

    S(O)2

    ,A represents a piperazine ring which may be further substituted or a piperidine ring which may be further substituted,X2 represents a bond or a lower alkylene which may be optionally substituted,Y2 represents —

    C(O)—

    , —

    S(O)—

    , —

    S(O)2

    or —

    C(═

    NR7)—

    (wherein R7 represents a hydrogen atom, a hydroxy group which may be optionally substituted, a lower alkoxycarbonyl group or an acyl group),X3 represents a C1-4 alkylene which may be optionally substituted or a C2-4 alkenylene which may be optionally substituted,in which two alkyl groups may be bound to each other to form an aryl ring together with carbon atoms which they attach to when X3 represents a C2-4 alkenylene substituted with two alkyl groups,Z3 represents —

    N(R4)—

    , —

    O—

    or a bond (wherein R4 represents a hydrogen atom, a hydrocarbon group which may be optionally substituted or an acyl group),represents a single bond or a double bond, whenrepresents a single bond, Z1 represents —

    C(R2)(R2′

    )—

    , —

    N(R2)—

    or —

    O—

    , and Z2 represents —

    C(R3)(R3′

    )—

    , —

    N(R3)—

    , —

    O—

    or a bond (provided that, when Z1 is —

    O—

    , Z2 is other than —

    O—

    ), and whenis a double bond, Z1 represents —

    C(R2)═

    or a nitrogen atom, and Z2 represents ═

    C(R3)—

    or a nitrogen atom,each of R2, R2′

    , R3 and R3′

    represents a hydrogen atom, a hydrocarbon group which may be optionally substituted or a heterocyclic group which may be optionally substituted, respectively, or each pair of R2 and R3, and R2′

    and R3′

    may be bound to each other respectively to form a ring which may be optionally substituted, or a salt thereof.

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