IMPLANTABLE SUCTION CUP COMPOSITES AND IMPLANTS COMPRISING SAME

• US 20100160892A1
• Filed: 12/21/2009
• Published: 06/24/2010
• Est. Priority Date: 12/23/2008
• Status: Active Grant

• Current Assignee: SurModics Pharmaceuticals, Inc
• Original Assignee: SurModics Pharmaceuticals, Inc
• Inventors: Tice, Thomas R.
• Granted Patent: US 9,415,197 B2
• Time in Patent Office: Days
• US Class Current: 604/500
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04

Abstract

Described herein are implantable composites, kits comprising the composites, implant devices comprising the composites, and methods of making and using same, including point of use methods.

Claims

1. An implantable composite comprising:

a cup member comprising a resilient biocompatible polymer and a bioactive agent;

wherein the cup member defines a cavity and has a substantially planar rim.

2. The implantable composite of claim 1, wherein the rim has a shape that is substantially circular, substantially rectangular, or substantially elliptical.

3. The implantable composite of claim 1, wherein the cup member further comprises an opacifier.

4. The implantable composite of claim 1, wherein the bioactive agent is encapsulated within a microparticle.

5. The implantable composite of claim 1, wherein the bioactive agent comprises at least one of an antibiotic, antimicrobial, a growth factor, a growth inhibitor, an immunomodulator, a steroid, or an anti-inflammatory.

6. The implantable composite of claim 1, wherein the implantable composite is secured to an implant device.

7. The implantable composite of claim 1, wherein the implantable composite is implanted in a subject.

11. A method of applying an implantable composite to an implant device, the method comprising securing the implantable composite of claim 1 onto a surface of an implant device, substantially close to the time when the implant device is implanted in a subject.

12. The method of claim 11, further comprising implanting the implant device in a subject.

13. The method of claim 11, wherein the implantable composite is secured to the surface of the implant device prior to the time when the implant device is implanted in the subject.

14. The method of claim 11, wherein the implantable composite is secured to the surface of the implant device at or after the time when the implant device is implanted in the subject.

15. The method of claim 11, wherein the implant device comprises a pump, pacemaker, defribrillator, or stimulator.

8. An implant device comprising:

implantable composite secured thereto;

wherein the implantable composite comprises a cup member comprising a resilient biocompatible polymer and a bioactive agent;

wherein the cup member defines a cavity and has a substantially planar rim.

9. The implant device of claim 8, wherein the implant device is implanted in a subject.

10. The implant device of claim 8, wherein the implant device comprises a pump, pacemaker, defribrillator, or stimulator.