Blood Flow Bypass Catheters and Methods for the Delivery of Medium to the Vasculature and Body Ducts
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Accused Products
Abstract
A catheterization device that may be designed by use of an adaptive genetic algorithm computational fluid dynamics approach, as well as other Global Optimization methods that may include simulated annealing, multistart and interval methods, continuous branch and bound methods, evolutionary algorithms, and tabu search and scatter search methods, as well as other available Global Optimization methods that is able to maximize/optimize the dwell time of an infused agent in the vicinity of a vascular lesion. The device may have an internal by-pass channel that allows the blood upstream of the lesion to continue its pulsatile flow through the vessel in the part of it occluded by the lesion, while simultaneously allowing the disbursement and maximal dwell time of an antithrombolytic or other diagnostic or therapeutic agent needed to treat the lesion. Different embodiments of the catheterization device are disclosed and indications for the use of these devices in the treatment of vascular diseases are discussed.
53 Citations
45 Claims
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1-27. -27. (canceled)
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28. A method for generating a configuration of elements of a catheter device for use inside a vasculature or body duct of a subject that includes inserting said catheter device into the subject, said catheter device comprising passages for blood flow and medium flow and inlet and exit ports for blood flow and medium flow, said method comprising:
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selecting variables including at least one of; a) geometrical shapes and dimensions of at least some of said blood passages and said medium passages, and b) relative locations and orientations of flow planes of at least some of said inlet ports and exit ports; and applying a global optimization algorithm to the variables to generate a catheter with optimized flow conditions. - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36)
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37. A computer program product comprising a computer useable medium having computer program logic for enabling at least one processor in a computer system to generate a configuration of elements on a catheter device, wherein said catheter device intended for use inside a vasculature or body duct of a subject that includes inserting said catheter device into the subject, said catheter device comprising passages for blood flow and medium flow and inlet and exit ports for blood flow and medium flow, said computer program logic comprising:
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selecting variables including at least one of; a) geometrical shapes and dimensions of at least some of said blood passages and said medium passages, and b) relative locations and orientations of flow planes of at least some of said inlet ports and exit ports; and applying a global optimization algorithm to the variables to generate a catheter with optimized flow conditions. - View Dependent Claims (38, 39, 40, 41, 42, 43, 44)
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45-67. -67. (canceled)
Specification