SENSOR SYSTEM FOR DETERMINING CONCENTRATION OF CHEMICAL AND BIOLOGICAL ANALYTES
First Claim
1. A sensor system for determining concentration of chemical and biological analytes, comprising:
- a. a disposable reagent-carrying pipette tip;
b. a liquid handling unit to which the pipette tip can be detachably mounted, the liquid handling unit capable of withdrawing liquid into the pipette tip;
c. at least one light source that is capable of emitting at least two colors of light;
d. at least one photodetector, the detector capable of generating an electronic signal response indicative of light passed through or generated from the interior space of the pipette tip; and
e. an electronic circuit means for processing, storing and transmitting the electronic signal response and controlling the light source.
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Accused Products
Abstract
A sensor system for determining a concentration of chemical and biological analytes is disclosed, which comprises a disposable reagent-carrying pipette tip; a liquid handling unit to which the pipette tip can be detachably mounted, the liquid handling unit capable of withdrawing liquid into the pipette tip; at least one light source; at least one photodetector, the detector capable of generating an electronic signal response indicative of light passed through or generated from the interior space of the pipette tip; and an electronic circuit means for processing, storing and transmitting the electronic signal response and controlling the light source.
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Citations
36 Claims
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1. A sensor system for determining concentration of chemical and biological analytes, comprising:
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a. a disposable reagent-carrying pipette tip; b. a liquid handling unit to which the pipette tip can be detachably mounted, the liquid handling unit capable of withdrawing liquid into the pipette tip; c. at least one light source that is capable of emitting at least two colors of light; d. at least one photodetector, the detector capable of generating an electronic signal response indicative of light passed through or generated from the interior space of the pipette tip; and e. an electronic circuit means for processing, storing and transmitting the electronic signal response and controlling the light source. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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28. A method for determining analytes concentration of a chemical and biological substance, the method comprising:
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a. providing a reagent-carrying disposable pipette tip; b. mounting the pipette tip to a liquid handling unit; c. measuring at least two initial spectrophotometric parameters before a liquid sample is drawn into the liquid handling unit; d. drawing the liquid sample into the pipette tip; e. measuring two response spectrophotometric parameters at a give time or multiple times; f. calculating a normalized parameter using initial parameters and response parameters; and g. converting the normalized parameter to a concentration of analyte. - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36)
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Specification