SUBSTITUTED 3-AMINO-4 -HYDROXY PYRROLIDINES COMPOUNDS, THEIR PREPARATION AND USE AS MEDICAMENTS

• US 20100168093A1
• Filed: 04/30/2007
• Published: 07/01/2010
• Est. Priority Date: 04/28/2006
• Status: Abandoned Application

• Current Assignee: Laboratories Del Dr Esteve SA (Corporation Quimico Farmaceutica Esteve SA)
• Original Assignee: Laboratories Del Dr Esteve SA (Corporation Quimico Farmaceutica Esteve SA)
• Inventors: Pericas-Brondo, Miguel Angel, Cordobés, Félix Cuevas, Granda, Carmen Garcia, Torrens-Jover, Antoni, Yenes-Minguez, Susana
• Application Number:
  US12/226,560
• Publication Number:
  US 20100168093A1
• Time in Patent Office: Days
• US Class Current: 514/230.500
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: C07D 207/14 Nitrogen atoms not forming part of a nitro radical
• CPC Class Codes: C07D 207/48 Sulfur atoms
• CPC Class Codes: C07D 401/04 directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 401/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 413/14 containing three or more hetero rings
• CPC Class Codes: C07D 471/04 Ortho-condensed systems

Abstract

The present invention relates to substituted pyrrolidine compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animal.

Claims

1. Substituted pyrrolidine compounds of general formula (I),

wherein

R¹ represents a hydrogen atom, an unbranched or branched, saturated, optionally at least mono-substituted C_1-6-aliphatic radical;

a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing cycloalkyl group, which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing alkyl-cycloalkyl group in which the cycloalkyl group may be optionally at least mono-substituted;

an optionally at least mono-substituted aryl group which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

an optionally at least mono-substituted heteroaryl group which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

a branched or unbranched, optionally at least mono-substituted alkyl-aryl group in which the aryl group may be optionally at least mono-substituted and/or condensed with a mono- or polycyclic ring system;

a branched or unbranched, optionally at least mono-substituted alkyl-heteroaryl group in which the heteroaryl group may be optionally at least mono-substituted and/or condensed with a mono- or polycyclic ring system;

an optionally at least mono-substituted benzhydryl group;

a (C═

O)—

R⁵ group;

a group;

a (SO₂)—

R⁶ group;

or a (C═

O)—

NR⁷R^7a group;

R² represents a hydrogen atom;

a substituted or unsubstituted aliphatic group;

a (C═

O)—

R⁸ group;

a benzyl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH;

R³ and R⁴, equal or different, represent a hydrogen atom;

an unbranched or branched, saturated or unsaturated, optionally at least mono-substituted aliphatic radical;

a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing cycloalkyl group, which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing alkyl-cycloalkyl group in which the cycloalkyl group may be optionally at least mono-substituted;

an optionally at least mono-substituted aryl group which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

an optionally at least mono-substituted heteroaryl group which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-aryl group in which the aryl group may be optionally at least mono-substituted and/or condensed with a mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-heteroaryl group in which the heteroaryl group may be optionally at least mono-substituted and/or condensed with a mono- or polycyclic ring system;

with the condition (proviso) that R³ and R⁴ may not at the same time represent a hydrogen atom;

or

R³ and R⁴ together with their bridging nitrogen atom form

1) a saturated or unsaturated ring system A, comprising 1 to 3 optionally condensed rings, in which additionally at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

2) an A-X—

B group,

wherein

A represents a saturated or unsaturated ring system comprising 1 to 3 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

B represents a saturated or unsaturated ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

3) an A-X—

B—

Y—

C group,

wherein

A represents a saturated or unsaturated ring system comprising 1 to 3 optionally condensed rings, in which additionally at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

B represents a saturated or unsaturated ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

Y represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

C represents a saturated or unsaturated ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N₁ S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

R⁵ and R⁶ represent a hydrogen atom, an unbranched or branched, saturated or unsaturated, optionally at least mono-substituted aliphatic radical;

a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing cycloalkyl group, which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing alkyl-cycloalkyl group;

an optionally at least mono-substituted aryl group which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

an optionally at least mono-substituted heteroaryl group which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-aryl group in which the aryl group may be condensed with a mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-heteroaryl group in which the heteroaryl group may be condensed with a mono- or polycyclic ring system;

R⁷ and R^7a, identical or different, represent a hydrogen atom, an unbranched or branched, saturated or unsaturated, optionally at least mono-substituted aliphatic radical;

a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing cycloalkyl group, which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing alkyl-cycloalkyl group;

an optionally at least mono-substituted aryl group which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

an optionally at least mono-substituted heteroaryl group which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-aryl group in which the aryl group may be condensed with a mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-heteroaryl group in which the heteroaryl group may be condensed with a mono- or polycyclic ring system;

R⁸ represents a hydrogen atom;

a branched or unbranched, saturated or unsaturated, unsubstituted aliphatic group;

R⁹, R¹⁰ and R¹¹ represent a hydrogen atom, an unbranched or branched, saturated or unsaturated, optionally at least mono-substituted aliphatic radical;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing alkyl-cycloalkyl group;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-aryl group in which the aryl group may be condensed with a mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-heteroaryl group in which the heteroaryl group may be condensed with a mono- or polycyclic ring system;

R¹² and R^12a, identical or different, represent a hydrogen atom, an unbranched or branched, saturated or unsaturated, optionally at least mono-substituted aliphatic radical;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing alkyl-cycloalkyl group;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-aryl group in which the aryl group may be condensed with a mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-heteroaryl group in which the heteroaryl group may be condensed with a mono- or polycyclic ring system;

with the provisos that

if R² represents a hydrogen atom;

and R¹ represents a hydrogen atom or a condensed aryl group;

R³ and R⁴ may not form together with their bridging nitrogen atom a triazole group;

if R² represents a hydrogen atom;

and R¹ represents a hydrogen atom;

a substituted C_1-2 alkyl group;

a condensed aryl group;

a benzyl group;

R³ and R⁴ may not form together with their bridging nitrogen atom a substituted, unsaturated, condensed ring system containing at least 4 nitrogen atoms as ring members;

an unsaturated, (C═

O)-substituted, uncondensed, 6-membered ring system in which one additional carbon atom is replaced by nitrogen.

if R² represents a hydrogen atom;

and R³ and R⁴ form together with their bridging nitrogen atom a pyrrolidine ring, a piperidine ring, a piperazine ring or a morpholine ring;

R¹ may not represent a hydrogen atom;

a methyl group;

an unsaturated tert-butyl group;

a (C═

O)-substituted alkyl-heteroaryl group;

if R² represents a hydrogen atom;

and R¹ does not represent a benzyl group;

and either R³ or R⁴ represents a hydrogen atom;

either R³ or R⁴ may not represent a substituted alkyl-heteroaryl group;

an alkyl-aryl group;

a substituted heteroaryl group;

an unsubstituted methyl group;

a substituted alkyl group;

an aryl group;

a cyclohexyl group;

an alkyl-cycloalkyl group wherein the cycloalkyl group contains at least one heteroatom;

if R² represents a hydrogen atom;

and R¹ represents an alkyl group;

and either R³ or R⁴ represents a hydrogen atom;

the other of R³ or R⁴ may not represent a substituted or unsubstituted C_1-2 alkyl group;

a branched C_1-4 alkyl group;

a substituted or unsubstituted C_3-6 cycloalkyl group in which optionally at least one carbon atom is optionally replaced by N, S or O;

a cycloheptyl group;

if R² represents a hydrogen atom;

and R¹ represents an alkyl group;

either R³ or R⁴ may not represent a cyclohexyl group while the other represents at the same time an alkyl-aryl group;

or either R³ or R⁴ may not represent an alkyl group while the other represents at the same time an alkyl-aryl group;

if R² represents a hydrogen atom;

and R¹ represents a benzhydryl group;

and either R³ or R⁴ represents a hydrogen atom;

either R³ or R⁴ may not represent a (C═

O)-substituted alkyl-aryl group;

a (C═

O)-substituted aryl group;

if R² represents a hydrogen atom;

and R¹ represents benzyl;

and either R³ or R⁴ represents a hydrogen atom;

the other of R³ or R⁴ may not represent a substituted or unsubstituted C_1-2 alkyl group;

an unsubstituted benzyl group;

a C_3-8 substituted alkyl group;

a substituted alkyl-aryl group;

or

R³ or R⁴, together with their bridging nitrogen atom may not form a tetrahydropyrimidine ring;

a triazolo pyrimidine ring;

if R² represents a benzyl group;

and either R³ or R⁴ represents a hydrogen atom either R³ or R⁴ may not represent a (C═

O)-substituted alkyl-aryl group;

if R² represents a C_1-3 alkyl group;

and either R³ or R⁴ represents a hydrogen atom either R³ or R⁴ may not represent an unsubstituted C_1-2 alkyl group;

a substituted alkyl group;

a substituted or unsubstituted aryl group;

a substituted heteroaryl group;

a (C═

O)-substituted alkyl-aryl group;

optionally in form of one of the stereoisomers, preferably enantiomers or diastereomers, a racemate or in form of a mixture of at least two of the stereoisomers, preferably enantiomers and/or diastereomers, in any mixing ratio, or a corresponding salt thereof, or a corresponding solvate thereof.

2. Compound according to claim 1, characterized in that R¹ represents a hydrogen atom, an unbranched or branched, optionally at least mono-substituted C_1-6-alkyl radical;

a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing cycloalkyl group, which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing alkyl-cycloalkyl group in which the cycloalkyl group may be optionally at least mono-substituted;

an optionally at least mono-substituted aryl group which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

an optionally at least mono-substituted heteroaryl group which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

a branched or unbranched, saturated, optionally at least mono-substituted alkyl-aryl group in which the aryl group may be optionally at least mono-substituted and/or condensed with a mono- or polycyclic ring system;

a branched or unbranched, saturated, optionally at least mono-substituted alkyl-heteroaryl group in which the heteroaryl group may be optionally at least mono-substituted and/or condensed with a mono- or polycyclic ring system;

an optionally at least mono-substituted benzhydryl group;

a (C═

O)—

R⁵ group;

a group;

a (SO₂)—

R⁸ group;

or a (C═

O)—

NR⁷R^7a group;

R² represents a (C═

O)—

R⁸ group, with R⁸ representing a hydrogen atom;

a branched or unbranched, saturated or unsaturated, unsubstituted aliphatic group;

R³ and R⁴, equal or different, represent a hydrogen atom;

an unbranched or branched, saturated or unsaturated, optionally at least mono-substituted C_1-8-aliphatic radical;

a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing cycloalkyl group, which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing alkyl-cycloalkyl group in which the cycloalkyl group may be optionally at least mono-substituted;

an optionally at least mono-substituted aryl group which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

an optionally at least mono-substituted heteroaryl group which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-aryl group in which the aryl group may be optionally at least mono-substituted and/or condensed with a mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-heteroaryl group in which the heteroaryl group may be optionally at least mono-substituted and/or condensed with a mono- or polycyclic ring system;

with the condition (proviso) that R³ and R⁴ may not at the same time represent a hydrogen atom;

or

R³ and R⁴ together with their bridging nitrogen atom form

1) a saturated or unsaturated ring system A, comprising 1 to 3 optionally condensed rings, in which additionally at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

2) an A-X—

B group,

wherein

A represents a saturated or unsaturated ring system comprising 1 to 3 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₂, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

B represents a saturated or unsaturated ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N₁ S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

N R¹²R^12a group;

3) an A-X—

B—

Y—

C group,

wherein

A represents a saturated or unsaturated ring system comprising 1 to 3 optionally condensed rings, in which additionally at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

B represents a saturated or unsaturated ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

Y represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

C represents a saturated or unsaturated ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹¹ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

R⁵, R⁶, R^7a, R⁹, R¹⁰, R¹¹, R¹² and R^12a have the meaning according to claim 1;

optionally in form of one of the stereoisomers, preferably enantiomers or diastereomers, a racemate or in form of a mixture of at least two of the stereoisomers, preferably enantiomers and/or diastereomers, in any mixing ratio, or a corresponding salt thereof, or a corresponding solvate thereof.

3. Compounds according to claim 1, characterized in that R¹ represents a hydrogen atom, an unbranched or branched, saturated, optionally at least mono-substituted C_1-6-alkyl radical;

a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing cycloalkyl group, which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing alkyl-cycloalkyl group in which the cycloalkyl group may be optionally at least mono-substituted;

an optionally at least mono-substituted aryl group which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

an optionally at least mono-substituted heteroaryl group which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

a branched or unbranched, saturated, optionally at least mono-substituted alkyl-aryl group in which the aryl group may be optionally at least mono-substituted and/or condensed with a mono- or polycyclic ring system;

a branched or unbranched, saturated, optionally at least mono-substituted alkyl-heteroaryl group in which the heteroaryl group may be optionally at least mono-substituted and/or condensed with a mono- or polycyclic ring system;

an optionally at least mono-substituted benzhydryl group;

a (C═

O)—

R⁵ group;

a group;

a (SO₂)—

R⁶ group;

or a (C═

O)—

NR⁷R^7a group;

R² represents a linear, substituted or unsubstituted C C_1-6 alkyl group;

or a benzyl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH;

R³ and R⁴ together with their bridging nitrogen atom form

1) a saturated or unsaturated ring system A, comprising 1 to 3 optionally condensed rings, in which additionally at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

2) an A-X—

B group,

wherein

A represents a saturated or unsaturated ring system comprising 1 to 3 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

B represents a saturated or unsaturated ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

3) an A-X—

B—

Y—

C group,

wherein

A represents a saturated or unsaturated ring system comprising 1 to 3 optionally condensed rings, in which additionally at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

B represents a saturated or unsaturated ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

Y represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

C represents a saturated or unsaturated ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

R⁵, R⁶, R⁷, R^7a, R⁹, R¹⁰, R¹¹, R¹² and R^12a have the meaning according to claim 1;

optionally in form of one of the stereoisomers, preferably enantiomers or diastereomers, a racemate or in form of a mixture of at least two of the stereoisomers, preferably enantiomers and/or diastereomers, in any mixing ratio, or a corresponding salt thereof, or a corresponding solvate thereof.

4. Compounds according to claim 1, characterized in that R¹ represents a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing alkyl-cycloalkyl group in which the cycloalkyl group may be optionally at least mono-substituted;

an optionally at least mono-substituted heteroaryl group;

a branched or unbranched, optionally at least mono-substituted alkyl-aryl group in which the aryl group may be optionally at least mono-substituted and/or condensed with a mono- or polycyclic ring system;

a branched or unbranched, saturated, optionally at least mono-substituted alkyl-heteroaryl group in which the heteroaryl group may be optionally at least mono-substituted and/or condensed with a mono- or polycyclic ring system;

an optionally at least mono-substituted benzhydryl group;

a (C═

O)—

R⁵ group;

a group;

a (SO₂)—

R⁶ group;

or a (C═

O)—

NR⁷R^7a group;

R² represents a linear, substituted or unsubstituted C_1-6 alkyl group;

or a benzyl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH;

R³ and R⁴, identical or different, represent a hydrogen atom;

a saturated or unsaturated, unsubstituted C_3-8 aliphatic group;

a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing cycloalkyl group;

an unsubstituted heteroaryl group;

a saturated or unsaturated, optionally at least mono-substituted alkyl-cycloalkyl group;

an unsubstituted alkyl-aryl group;

a saturated or unsaturated, optionally at least mono-substituted alkyl-heteroaryl group;

with the condition that R³ and R⁴ may not at the same time represent a hydrogen atom;

R⁵, R⁶, R⁷ and R^7a have the meaning according to claim 1;

optionally in form of one of the stereoisomers, preferably enantiomers or diastereomers, a racemate or in form of a mixture of at least two of the stereoisomers, preferably enantiomers and/or diastereomers, in any mixing ratio, or a corresponding salt thereof, or a corresponding solvate thereof.

5. Compounds according to claim 1, characterized in that R¹ represents an unbranched or branched, optionally at least mono-substituted C_2-6-alkyl radical;

a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing cycloalkyl group, which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing alkyl-cycloalkyl group in which the cycloalkyl group may be optionally at least mono-substituted;

an optionally at least mono-substituted aryl group which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

an optionally at least mono-substituted heteroaryl group which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

a branched or unbranched, saturated, optionally at least mono-substituted alkyl-aryl group in which the aryl group may be optionally at least mono-substituted and/or condensed with a mono- or polycyclic ring system;

a branched or unbranched, saturated unsubstituted alkyl-heteroaryl group in which the heteroaryl group may be optionally at least mono-substituted and/or condensed with a mono- or polycyclic ring system;

an optionally at least mono-substituted benzhydryl group;

a (C═

O)—

R⁵ group;

a (SO₂)—

R⁶ group;

a (C═

O)—

NR⁷R^7a group;

R² represents a hydrogen atom;

R³ and R⁴ together with their bridging nitrogen atom form

1) a ring system A in which the ring containing the nitrogen atom is saturated, but may be condensed with an unsaturated ring, comprising 1 to 3 optionally condensed rings, in which additionally at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

2) an A-X—

B group,

wherein

A represents a ring system in which the ring containing the nitrogen atom is saturated, but may be condensed with an unsaturated ring, comprising 1 to 3 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₂, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

B represents a saturated or unsaturated ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₂, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

3) an A-X—

B—

Y—

C group,

wherein

A represents a ring system in which the ring containing the nitrogen atom is saturated, but may be condensed with an unsaturated ring, comprising 1 to 3 optionally condensed rings, in which additionally at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₂, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

B represents a saturated or unsaturated ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

Y represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

C represents a saturated or unsaturated ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

R⁵, R⁶, R⁷, R^7a, R⁹, R¹⁰, R¹¹, R¹² and R^12a have the meaning according to claim 1;

optionally in form of one of the stereoisomers, preferably enantiomers or diastereomers, a racemate or in form of a mixture of at least two of the stereoisomers, preferably enantiomers and/or diastereomers, in any mixing ratio, or a corresponding salt thereof, or a corresponding solvate thereof.

6. Compounds according to claim 1, characterized in that R¹ represents a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing alkyl-cycloalkyl group in which the cycloalkyl group may be optionally at least mono-substituted;

an optionally at least mono-substituted heteroaryl group which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

a branched or unbranched, saturated, optionally at least mono-substituted alkyl-aryl group in which the aryl group may be optionally at least mono-substituted and/or condensed with a mono- or polycyclic ring system;

a branched or unbranched, saturated, optionally at least mono-substituted alkyl-heteroaryl group in which the heteroaryl group may be optionally at least mono-substituted and/or condensed with a mono- or polycyclic ring system;

an optionally at least mono-substituted benzhydryl group;

a (C═

O)—

R⁵ group;

a (SO₂)—

R⁶ group;

or a (C═

O)—

NR⁷R^7a group;

R² represents a hydrogen atom;

R³ represents a hydrogen atom;

R⁴ represents a saturated or unsaturated, unsubstituted, linear C_3-8 aliphatic group;

a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing 4 or 5-membered cycloalkyl group;

an unsubstituted heteroaryl group;

a saturated or unsaturated, unsubstituted alkyl-cycloalkyl group;

an unsubstituted C_1-6alkyl-heteroaryl group;

R⁵, R⁶, R⁷ and R^7a have the meaning according to claim 1;

optionally in form of one of the stereoisomers, preferably enantiomers or diastereomers, a racemate or in form of a mixture of at least two of the stereoisomers, preferably enantiomers and/or diastereomers, in any mixing ratio, or a corresponding salt thereof, or a corresponding solvate thereof.

7. Compounds according to claim 1, characterized in that R¹ represents a hydrogen atom, an unbranched or branched, saturated C_1-6 alkyl radical which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a cycloalkyl group selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, adamantyl, pyrroline, pyrrolidine, pyrrolidineone, pyrazoline, pyrazolinone, oxopyrazolinone, aziridine, acetidine, tetrahydropyrrole, oxirane, oxetane, dioxetane, tetrahydrofurane, dioxane, dioxolane, oxathiolane, oxazolidine, thiirane, thietane, thiolane, thiane, thiazolidine, piperidine, piperazine or morpholine which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

an optionally at least one heteroatom as ring member containing C_1-6-alkyl-cycloalkyl group wherein the C_1-6-alkyl and/or the cycloalkyl group is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

an aryl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a heteroaryl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a branched or unbranched, saturated C_3-6-alkyl-aryl group wherein the C_3-6-alkyl and/or the aryl group is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a branched or unbranched, saturated C_3-6-alkyl-heteroaryl group wherein the C_3-6-alkyl and/or the aryl group is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a benzhydryl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a (C═

O)—

R⁵ group;

a (SO₂)—

R⁶ group;

or a (C═

O)—

NR⁷R^7a group;

R² represents a (C═

O)—

R⁸ group, with R⁸ representing a hydrogen atom;

a branched or unbranched, saturated or unsaturated, unsubstituted aliphatic group;

R³ and R⁴, equal or different, represent a hydrogen atom, an unbranched or branched, saturated or unsaturated, optionally at least mono-substituted C_1-8-aliphatic radical;

a saturated or unsaturated, optionally at least mono- substituted, optionally at least one heteroatom as ring member containing cycloalkyl group;

a branched or unbranched, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing C_1-6-alkyl-cycloalkyl group;

an optionally at least mono-substituted aryl group;

an optionally at least mono-substituted heteroaryl group;

a branched or unbranched, optionally at least mono-substituted C_1-6-alkyl-aryl group;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted C_1-6-alkyl-heteroaryl group;

with the condition that R³ and R⁴ may at the same time not represent a hydrogen atom;

or

R³ and R⁴ together with their bridging nitrogen atom form

1) a saturated or unsaturated ring system A, comprising 1 to 3 optionally condensed rings, in which additionally at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

2) an A-X—

B group,

wherein

A represents a saturated or unsaturated ring system comprising 1 to 3 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

B represents a saturated or unsaturated ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

3) an A-X—

B—

Y—

C group,

wherein

A represents a saturated or unsaturated ring system comprising 1 to 3 optionally condensed rings, in which additionally at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

B represents a saturated or unsaturated ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₂, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

Y represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

C represents a saturated or unsaturated ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₂, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH₂-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

R⁵, R⁶, R⁷, R^7a, R⁹, R¹⁰, R¹¹, R¹² and R^12a have the meaning according to claim 1;

optionally in form of one of the stereoisomers, preferably enantiomers or diastereomers, a racemate or in form of a mixture of at least two of the stereoisomers, preferably enantiomers and/or diastereomers, in any mixing ratio, or a corresponding salt thereof, or a corresponding solvate thereof.

8. Compounds according to claim 1, characterized in that R¹ represents a hydrogen atom, an unbranched or branched, saturated C_1-6 alkyl radical which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a cycloalkyl group selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, adamantyl, pyrroline, pyrrolidine, pyrrolidineone, pyrazoline, pyrazolinone, oxopyrazolinone, aziridine, acetidine, tetrahydropyrrole, oxirane, oxetane, dioxetane, tetrahydrofurane, dioxane, dioxolane, oxathiolane, oxazolidine, thiirane, thietane, thiolane, thiane, thiazolidine, piperidine, piperazine or morpholine which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, carboxy, amido, cyano, carbamyl, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

an optionally at least one heteroatom as ring member containing C_1-6-alkyl-cycloalkyl group wherein the C_1-6-alkyl and/or the cycloalkyl group is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

an aryl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₂, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a heteroaryl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a branched or unbranched, saturated C_1-6-alkyl-aryl group wherein the C_1-6-alkyl and/or the aryl group is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₂, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a branched or unbranched, saturated, C_1-6-alkyl-heteroaryl group wherein the C_1-6-alkyl and/or the heteroaryl group is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH₁ OH, SO₂, CF₂, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

an optionally at least mono-substituted benzhydryl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₂, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a (C═

O)—

R⁵ group;

a group;

a (SO₂)—

R⁶ group;

or a (C═

O)—

NR⁷R^7a group;

R² represents a C_1-6 alkyl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₂;

or a benzyl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₂;

R³ and R⁴ together with their bridging nitrogen atom form

1) a saturated or unsaturated ring system A, comprising 1 to 3 optionally condensed rings, in which additionally at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹² group;

2) an A-X—

B group,

wherein

A represents a saturated or unsaturated ring system comprising 1 to 3 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹² group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

B represents a saturated or unsaturated ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

3) an A-X—

B—

Y—

C group,

wherein

A represents a saturated or unsaturated ring system comprising 1 to 3 optionally condensed rings, in which additionally at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

B represents a saturated or unsaturated ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

Y represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

C represents a saturated or unsaturated ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH₂-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

R⁵, R⁶, R⁷, R^7a, R⁹, R¹⁰, R¹¹, R¹² and R^12a have the meaning according to claim 1;

optionally in form of one of the stereoisomers, preferably enantiomers or diastereomers, a racemate or in form of a mixture of at least two of the stereoisomers, preferably enantiomers and/or diastereomers, in any mixing ratio, or a corresponding salt thereof, or a corresponding solvate thereof.

9. Compounds according to claim 1, characterized in that R¹ represents an optionally at least one heteroatom as ring member containing C_1-6-alkyl-cycloalkyl group wherein the C_1-6-alkyl and/or the cycloalkyl group is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a heteroaryl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a branched or unbranched, saturated C_1-6-alkyl-aryl group wherein the C_1-6-alkyl and/or the aryl group is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a branched or unbranched, saturated C_1-6-alkyl-heteroaryl group wherein the C_1-6-alkyl and/or the aryl group is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a benzhydryl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a (C═

O)—

R⁵ group;

a (SO₂)—

R⁶ group;

or a (C═

O)—

NR⁷R^7a group;

R² represents a C_1-6 alkyl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

or a benzyl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH₁ CF₃;

R³ and R⁴, identical or different, represent a hydrogen atom;

a saturated or unsaturated, unsubstituted C_3-8 aliphatic group;

a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing cycloalkyl group with substituents independently selected from the group consisting of F₁ Cl, Br, I, NH₂, SH, OH, CF₃, CN₁ nitro;

an unsubstituted heteroaryl group;

an optionally at least mono-substituted C_1-6 alkyl-cycloalkyl group;

an unsubstituted C_1-6 alkyl-aryl group;

an unsubstituted C_1-6 alkyl-heteroaryl group;

with the condition that R³ and R⁴ may not at the same time represent a hydrogen atom;

R⁵, R⁶, R⁷ and R^7a have the meaning according to claim 1;

optionally in form of one of the stereoisomers, preferably enantiomers or diastereomers, a racemate or in form of a mixture of at least two of the stereoisomers, preferably enantiomers and/or diastereomers, in any mixing ratio, or a corresponding salt thereof, or a corresponding solvate thereof.

10. Compounds according to claim 1, characterized in that R¹ represents an unbranched or branched, optionally at least mono-substituted C_1-6-alkyl radical which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a cycloalkyl group selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, adamantyl, pyrroline, pyrrolidine, pyrrolidineone, pyrazoline, pyrazolinone, oxopyrazolinone, aziridine, acetidine, tetrahydropyrrole, oxirane, oxetane, dioxetane, tetrahydrofurane, dioxane, dioxolane, oxathiolane, oxazolidine, thiirane, thietane, thiolane, thiane, thiazolidine, piperidine, piperazine or morpholine which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

an optionally at least one heteroatom as ring member containing C_1-6-alkyl-cycloalkyl group wherein the C_1-6-alkyl and/or the cycloalkyl group is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

an aryl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a heteroaryl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a branched or unbranched C_3-6-alkyl-aryl group wherein the C_1-6-alkyl and/or the aryl group is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a branched or unbranched C_1-6-alkyl-heteroaryl group wherein the C_1-6-alkyl and/or the aryl group is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a benzhydryl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a (C═

O)—

R⁵ group;

a (SO₂)—

R⁶ group;

or a (C═

O)—

NR⁷R^7a group;

R² represents a hydrogen atom;

R³ and R⁴ together with their bridging nitrogen atom form

1) a 4 to 18 membered ring system A in which the ring containing the nitrogen atom is saturated, but may be condensed with an unsaturated ring, comprising 1 to 3 optionally condensed rings, in which additionally at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

2) an A-X—

B group,

wherein

A represents 4 to 18 membered ring system in which the ring containing the nitrogen atom is saturated, but may be condensed with an unsaturated ring, comprising 1 to 3 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

B represents a saturated or unsaturated 4 to 12 membered ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R¹² group;

3) an A-X—

B—

Y—

C group,

wherein

A represents 4 to 18 membered ring system in which the ring containing the nitrogen atom is saturated, but may be condensed with an unsaturated ring, comprising 1 to 3 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

B represents a saturated or unsaturated 4 to 12 membered ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

Y represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

C represents a saturated or unsaturated 4 to 12 membered ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₂, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a —

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

R⁵, R⁵, R⁷, R^7a, R⁹, R¹⁰, R¹¹, R¹² and R^12a have the meaning according to claim 1;

optionally in form of one of the stereoisomers, preferably enantiomers or diastereomers, a racemate or in form of a mixture of at least two of the stereoisomers, preferably enantiomers and/or diastereomers, in any mixing ratio, or a corresponding salt thereof, or a corresponding solvate thereof.

11. Compounds according to any of claims 1, characterized in that R¹ represents an optionally at least one heteroatom as ring member containing cycloalkyl group wherein the C_1-6-alkyl and/or the cycloalkyl group is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a heteroaryl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a branched or unbranched C_1-6-alkyl-aryl group wherein the C_1-6-alkyl and/or the aryl group is optional;

substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a branched or unbranched C_1-6-alkyl-heteroaryl group wherein the C_1-6-alkyl and/or the aryl group is optional;

substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a benzhydryl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN₁ nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a (C═

O)—

R⁵ group;

a (SO₂)—

R⁶ group;

or a (C═

O)—

NR⁷R^7a group;

R² represents a hydrogen atom;

R³ represents a hydrogen atom;

R⁴ represents a saturated or unsaturated, unsubstituted, linear C_3-8 aliphatic group;

a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing 4 or 5-membered cycloalkyl group;

an unsubstituted heteroaryl group;

a saturated or unsaturated, unsubstituted alkyl-cycloalkyl group;

an unsubstituted C_1-6 alkyl-heteroaryl group;

R⁵, R⁶, R⁷ and R^7a have the meaning according to claim 1;

optionally in form of one of the stereoisomers, preferably enantiomers or diastereomers, a racemate or in form of a mixture of at least two of the stereoisomers, preferably enantiomers and/or diastereomers, in any mixing ratio, or a corresponding salt thereof, or a corresponding solvate thereof.

12. Compound according to claim 1, characterized in that R¹ represents a hydrogen atom, an unbranched or branched C_1-6 alkyl radical which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH;

OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a cycloalkyl group selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, adamantyl, pyrroline, pyrrolidine, pyrrolidineone, pyrazoline, pyrazolinone, oxopyrazolinone, aziridine, acetidine, tetrahydropyrrole, oxirane, oxetane, dioxetane, tetrahydrofurane, dioxane, dioxolane, oxathiolane, oxazolidine, thiirane, thietane, thiolane, thiane, thiazolidine, piperidine, piperazine or morpholine which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

an optionally at least one heteroatom as ring member containing C_1-6-alkyl-cycloalkyl group wherein the C_1-6-alkyl and/or the cycloalkyl group is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

an aryl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a heteroaryl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN₁ nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a branched or unbranched C_1-6-alkyl-aryl group wherein the C_1-6-alkyl and/or the aryl group is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a branched or unbranched C_1-6-alkyl-heteroaryl group wherein the C_1-6-alkyl and/or the aryl group is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a benzhydryl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN₁ nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a (SO₂)—

R⁶ group;

R² represents a (C═

O)—

R⁸ group, with R⁸ representing a hydrogen atom;

a methyl group;

an ethyl group;

a propyl group;

a butyl group;

a pentyl group;

a hexyl group;

R³ and R⁴, equal or different, represent a hydrogen atom, an unbranched or branched C_1-8-alkyl group, which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a saturated or unsaturated, optionally at least one heteroatom as ring member containing cycloalkyl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a branched or unbranched, optionally at least one heteroatom as ring member containing C_1-6-alkyl-cycloalkyl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

an aryl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, CO—

OH, CO—

O—

CH₃, O—

CH₃, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a heteroaryl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, CO—

OH, CO—

O—

CH₃, O—

CH₃, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a branched or unbranched C_1-6-alkyl-aryl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, CO—

OH, CO—

O—

CH₃, O—

CH₃, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a branched or unbranched C_1-6-alkyl-heteroaryl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

with the condition that R³ and R⁴ may at the same time not represent a hydrogen atom;

or

R³ and R⁴ together with their bridging nitrogen atom form

1) a saturated or unsaturated 4 to 18 membered ring system A, comprising 1 to 3 optionally condensed rings, in which additionally at least 1 carbon atom is optionally replaced by N or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a OH₂—

(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

2) an A-X—

B group,

wherein

A represents a saturated or unsaturated 4 to 18 membered ring system comprising 1 to 3 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH₂—

(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted 0_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

B represents a saturated or unsaturated 4 to 12 membered ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH₂—

(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

3) an A-X—

B—

Y—

C group,

wherein

A represents a saturated or unsaturated 4 to 18 membered ring system comprising 1 to 3 optionally condensed rings, in which additionally at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH₂—

(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ⁿ group;

a NH—

R¹¹ group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

B represents a saturated or unsaturated 4 to 12 membered ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH₂-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

Y represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

C represents a saturated or unsaturated 4 to 12 membered ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH₁ OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH₂-(C═

O)—

O—

R¹¹ group;

a (SO²)—

R¹¹ group;

a NH—

R¹¹ group;

R⁶ represents a hydrogen atom;

a C_1-6 alkyl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

a cycloalkyl group selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, adamantyl, pyrroline, pyrrolidine, pyrrolidineone, pyrazoline, pyrazolinone, oxopyrazolinone, aziridine, acetidine, tetrahydropyrrole, oxirane, oxetane, dioxetane, tetrahydrofurane, dioxane, dioxolane, oxathiolane, oxazolidine, thiirane, thietane, thiolane, thiane, thiazolidine, piperidine, piperazine or morpholine which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, or CN;

an alkyl-cycloalkyl group which is optionally at least mono- substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

an aryl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

a heteroaryl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

a branched or unbranched alkyl-aryl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

an alkyl-heteroaryl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

R⁹, R¹⁰ and R¹¹ represent a hydrogen atom, an unbranched or branched C_1-6 alkyl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

an alkyl-cycloalkyl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

a branched or unbranched alkyl-aryl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

an alkyl-heteroaryl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

optionally in form of one of the stereoisomers, preferably enantiomers or diastereomers, a racemate or in form of a mixture of at least two of the stereoisomers, preferably enantiomers and/or diastereomers, in any mixing ratio, or a corresponding salt thereof, or a corresponding solvate thereof.

13. Compounds according to claim 1, characterized in that R¹ represents a hydrogen atom, an unbranched or branched C_1-6 alkyl radical which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a cycloalkyl group selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, adamantyl, pyrroline, pyrrolidine, pyrrolidineone, pyrazoline, pyrazolinone, oxopyrazolinone, aziridine, acetidine, tetrahydropyrrole, oxirane, oxetane, dioxetane, tetrahydrofurane, dioxane, dioxolane, oxathiolane, oxazolidine, thiirane, thietane, thiolane, thiane, thiazolidine, piperidine, piperazine or morpholine which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, carboxy, amido, cyano, carbamyl, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

an optionally at least one heteroatom as ring member containing C_1-6-alkyl-cycloalkyl group wherein the C_1-6-alkyl and/or the cycloalkyl group is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

an aryl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a heteroaryl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a branched or unbranched, saturated C_1-6-alkyl-aryl group wherein the C_1-6-alkyl and/or the aryl group is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a branched or unbranched, saturated, C₁₆-alkyl-heteroaryl group wherein the C_1-6-alkyl and/or the heteroaryl group is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

an optionally at least mono-substituted benzhydryl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a group;

a (SO₂)—

R⁶ group;

R² represents a methyl , ethyl, propyl or butyl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

or a benzyl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

R³ and R⁴ together with their bridging nitrogen atom form

1) a saturated or unsaturated 4 to 18 membered ring system A, comprising 1 to 3 optionally condensed rings, in which additionally at least 1 carbon atom is optionally replaced by N or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_3-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH₂-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

2) an A-X—

B group,

wherein

A represents a saturated or unsaturated 4 to 18 membered ring system comprising 1 to 3 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH₂—

(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

B represents a saturated or unsaturated 4 to 12 membered ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH₂—

(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

3) an A-X—

B—

Y—

C group,

wherein

A represents a saturated or unsaturated 4 to 18 membered ring system comprising 1 to 3 optionally condensed rings, in which additionally at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH₂—

(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

B represents a saturated or unsaturated 4 to 12 membered ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH₂—

(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

Y represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

C represents a saturated or unsaturated 4 to 12 membered ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH₂—

(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

R⁶ represents a hydrogen atom;

a C_1-6 alkyl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

a cycloalkyl group selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, adamantyl, pyrroline, pyrrolidine, pyrrolidineone, pyrazoline, pyrazolinone, oxopyrazolinone, aziridine, acetidine, tetrahydropyrrole, oxirane, oxetane, dioxetane, tetrahydrofurane, dioxane, dioxolane, oxathiolane, oxazolidine, thiirane, thietane, thiolane, thiane, thiazolidine, piperidine, piperazine or morpholine which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, or CN;

an alkyl-cycloalkyl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

an aryl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

a heteroaryl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

a branched or unbranched alkyl-aryl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

an alkyl-heteroaryl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

R⁹, R¹⁰ and R¹¹ represent a hydrogen atom, an unbranched or branched C_1-6 alkyl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

an alkyl-cycloalkyl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

a branched or unbranched alkyl-aryl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

an alkyl-heteroaryl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

optionally in form of one of the stereoisomers, preferably enantiomers or diastereomers, a racemate or in form of a mixture of at least two of the stereoisomers, preferably enantiomers and/or diastereomers, in any mixing ratio, or a corresponding salt thereof, or a corresponding solvate thereof.

14. Compounds according to claim 1, characterized in that re represents an optionally at least one heteroatom as ring member containing C_1-6-alkyl-cycloalkyl group wherein the C_1-6-alkyl and/or the cycloalkyl group is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a heteroaryl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a branched or unbranched, saturated C_1-6-alkyl-aryl group wherein the C_1-6-alkyl and/or the aryl group is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a branched or unbranched, saturated C_1-6-alkyl-heteroaryl group wherein the C_1-6-alkyl and/or the aryl group is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a benzhydryl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I₁ NH₂, SH₁ OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a (SO₂)—

R⁶ group;

R² represents a methyl, ethyl, propyl or butyl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

or a benzyl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

R³ and R⁴, identical or different, represent a hydrogen atom;

a saturated or unsaturated, unsubstituted C_3-6 aliphatic group;

a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing cycloalkyl group with substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃, CN, nitro;

an unsubstituted heteroaryl group;

a C_1-6 alkyl-cycloalkyl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

an unsubstituted C_1-6 alkyl-aryl group;

an unsubstituted C₁-₆ alkyl-heteroaryl group;

with the condition that R³ and R⁴ may not at the same time represent a hydrogen atom;

R⁶ represents a hydrogen atom;

a C_1-6 alkyl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

a cycloalkyl group selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, adamantyl, pyrroline, pyrrolidine, pyrrolidineone, pyrazoline, pyrazolinone, oxopyrazolinone, aziridine, acetidine, tetrahydropyrrole, oxirane, oxetane, dioxetane, tetrahydrofurane, dioxane, dioxolane, oxathiolane, oxazolidine, thiirane, thietane, thiolane, thiane, thiazolidine, piperidine, piperazine or morpholine which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, or CN;

an alkyl-cycloalkyl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

an aryl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

a heteroaryl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

a branched or unbranched alkyl-aryl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

an alkyl-heteroaryl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

optionally in form of one of the stereoisomers, preferably enantiomers or diastereomers, a racemate or in form of a mixture of at least two of the stereoisomers, preferably enantiomers and/or diastereomers, in any mixing ratio, or a corresponding salt thereof, or a corresponding solvate thereof.

15. Compounds according to claim 1, characterized in that R¹ represents an unbranched or branched, saturated, optionally at least mono-substituted C_1-6-alkyl radical which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a cycloalkyl group selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, adamantyl, pyrroline, pyrrolidine, pyrrolidineone, pyrazoline, pyrazolinone, oxopyrazolinone, aziridine, acetidine, tetrahydropyrrole, oxirane, oxetane, dioxetane, tetrahydrofurane, dioxane, dioxolane, oxathiolane, oxazolidine, thiirane, thietane, thiolane, thiane, thiazolidine, piperidine, piperazine or morpholine which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

an optionally at least one heteroatom as ring member containing C_1-6-alkyl-cycloalkyl group wherein the C_1-6-alkyl and/or the cycloalkyl group is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

an aryl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a heteroaryl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a branched or unbranched, saturated group wherein the C_1-6-alkyl and/or the aryl group is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a branched or unbranched, saturated C_1-6-alkyl-heteroaryl group wherein the C_1-6-alkyl and/or the aryl group is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a benzhydryl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a (SO₂)—

R⁶ group;

R² represents a hydrogen atom;

R³ and R⁴ together with their bridging nitrogen atom form

1) a 4 to 18 membered ring system A in which the ring containing the nitrogen atom is saturated, but may be condensed with an unsaturated ring, comprising 1 to 3 optionally condensed rings, in which additionally at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

2) an A-X—

B group,

wherein

A represents a 4 to 18 membered ring system in which the ring containing the nitrogen atom is saturated, but may be condensed with an unsaturated ring, comprising 1 to 3 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH₂—

(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

X group;

a —

NH—

group;

a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

B represents a saturated or unsaturated 4 to 12 membered ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH₂—

(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

3) an A-X—

B—

Y—

C group,

wherein

A represents a 4 to 18 membered ring system in which the ring containing the nitrogen atom is saturated, but may be condensed with an unsaturated ring comprising 1 to 3 optionally condensed rings, in which additionally at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH₂—

(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

B represents a saturated or unsaturated 4 to 12 membered ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

Y represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

C represents a saturated or unsaturated 4 to β

membered ring system, in which at least 1 carbon atom is optionally replaced by N or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, or CF₃;

R⁶ represents a hydrogen atom;

a C_1-6 alkyl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

a cycloalkyl group selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, adamantyl, pyrroline, pyrrolidine, pyrrolidineone, pyrazoline, pyrazolinone, oxopyrazolinone, aziridine, acetidine, tetrahydropyrrole, oxirane, oxetane, dioxetane, tetrahydrofurane, dioxane, dioxolane, oxathiolane, oxazolidine, thiirane, thietane, thiolane, thiane, thiazolidine, piperidine, piperazine or morpholine which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, or CN;

an alkyl-cycloalkyl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

an aryl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

a heteroaryl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

a branched or unbranched alkyl-aryl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

an alkyl-heteroaryl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

R⁹, R¹⁰ and R¹¹ represent a hydrogen atom, an unbranched or branched alkyl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

an alkyl-cycloalkyl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

a branched or unbranched alkyl-aryl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

an alkyl-heteroaryl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

optionally in form of one of the stereoisomers, preferably enantiomers or diastereomers, a racemate or in form of a mixture of at least two of the stereoisomers, preferably enantiomers and/or diastereomers, in any mixing ratio, or a corresponding salt thereof, or a corresponding solvate thereof.

16. Compounds according to claim 1, characterized in that R¹ represents an optionally at least one heteroatom as ring member containing C_1-6-alkyl-cycloalkyl group wherein the C_1-6-alkyl and/or the cycloalkyl group is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN₁ nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a heteroaryl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a branched or unbranched, saturated C_1-6-alkyl-aryl group wherein the C_1-6-alkyl and/or the aryl group is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a branched or unbranched, saturated C_1-6-alkyl-heteroaryl group wherein the C_1-6-alkyl and/or the aryl group is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a benzhydryl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a (SO₂)—

R⁶ group;

R² represents a hydrogen atom;

R³ represents a hydrogen atom;

R⁴ represents a saturated or unsaturated, unsubstituted, linear C_3-13 aliphatic group;

a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing 4 or 5-membered cycloalkyl group;

an unsubstituted heteroaryl group;

a saturated or unsaturated, unsubstituted alkyl-cycloalkyl group;

an unsubstituted C_1-6 alkyl-heteroaryl group;

R⁶ represents a hydrogen atom;

a C_1-6 alkyl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

a cycloalkyl group selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, adamantyl, pyrroline, pyrrolidine, pyrrolidineone, pyrazoline, pyrazolinone, oxopyrazolinone, aziridine, acetidine, tetrahydropyrrole, oxirane, oxetane, dioxetane, tetrahydrofurane, dioxane, dioxolane, oxathiolane, oxazolidine, thiirane, thietane, thiolane, thiane, thiazolidine, piperidine, piperazine or morpholine which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, or CN;

an alkyl-cycloalkyl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

an aryl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

a heteroaryl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

a branched or unbranched alkyl-aryl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

an alkyl-heteroaryl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

optionally in form of one of the stereoisomers, preferably enantiomers or diastereomers, a racemate or in form of a mixture of at least two of the stereoisomers, preferably enantiomers and/or diastereomers, in any mixing ratio, or a corresponding salt thereof, or a corresponding solvate thereof.

17. Compounds according to claim 1, characterized in that R¹ represents a branched or unbranched C_1-6-alkyl-aryl group wherein the C_1-6-alkyl and/or the aryl group is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a branched or unbranched C_1-6-alkyl-heteroaryl group wherein the C_1-6-alkyl and/or the aryl group is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a benzhydryl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a (SO₂)—

R⁶ group with R⁶ being an aryl group, preferably a phenyl or a naphtyl group, which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

a heteroaryl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

R² represents a (C═

O)—

R⁸ group, with R⁸ representing a hydrogen atom;

a methyl group;

an ethyl group;

a propyl group;

a butyl group;

a pentyl group;

a hexyl group;

R³ and R⁴, identical or different, represent a hydrogen atom;

a C_3-8 alkyl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃, CN;

an optionally at least mono-substituted quinoline group;

a phenyl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃, CN;

a benzyl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃, CN;

with the condition that R³ and R⁴ may not at the same time represent a hydrogen atom;

or

R³ and R⁴ together with their bridging nitrogen atom form

1) a saturated or unsaturated 4 to 18 membered ring system A, comprising 1 to 3 optionally condensed rings, in which additionally at least 1 carbon atom is optionally replaced by N or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃;

a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a (C═

O)—

OR¹⁰ group with R¹⁰ being a linear or branched C_1-6 alkyl group;

2) an A-X—

B group,

wherein

A represents a saturated or unsaturated 4 to 18 membered ring system comprising 1 to 3 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃;

a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a (C═

O)—

OR¹⁰ group with R¹⁰ being a linear or branched C_1-6 alkyl group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

B represents a saturated or unsaturated 4 to 12 membered ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a (C═

O)—

OR¹⁰ group with Rⁿ being a linear or branched C_1-6 alkyl group;

3) an A-X—

B—

Y—

C group,

wherein

A represents a saturated or unsaturated 4 to 18 membered ring system comprising 1 to 3 optionally condensed rings, in which additionally at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₂, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a (C═

O)—

OR¹⁰ group with R¹⁰ being a linear or branched C_1-6 alkyl group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

B represents a saturated or unsaturated 4 to 12 membered ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a (C═

O)—

OR¹⁰ group with R¹⁰ being a linear or branched C_1-6 alkyl group;

Y represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

C represents a saturated or unsaturated 4 to 12 membered ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃;

a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a (C═

O)—

OR¹⁰ group with R¹⁰ being a linear or branched C_1-6 alkyl group;

optionally in form of one of the stereoisomers, preferably enantiomers or diastereomers, a racemate or in form of a mixture of at least two of the stereoisomers, preferably enantiomers and/or diastereomers, in any mixing ratio, or a corresponding salt thereof, or a corresponding solvate thereof.

18. Compounds according to claim 1, characterized in that R¹ represents a branched or unbranched C_1-6-alkyl-aryl group wherein the C_1-6-alkyl and/or the aryl group is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a branched or unbranched C_1-6-alkyl-heteroaryl group wherein the C_1-6-alkyl and/or the aryl group is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a benzhydryl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a (SO₂)—

R⁶ group with R⁶ being an aryl group, preferably a phenyl or a naphtyl group, which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

a heteroaryl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

R² represents a methyl, ethyl, propyl or butyl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

or a benzyl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

R³ and R⁴ together with their bridging nitrogen atom form

1) a saturated or unsaturated 4 to 18 membered ring system A, comprising 1 to 3 optionally condensed rings, in which additionally at least 1 carbon atom is optionally replaced by N or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃;

a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a (C═

O)—

OR¹⁶ group with R¹⁰ being a linear or branched C_1-6 alkyl group;

2) an A-X—

B group,

wherein

A represents a saturated or unsaturated 4 to 18 membered ring system comprising 1 to 3 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃;

a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a (C═

O)—

OR¹⁰ group with R¹⁰ being a linear or branched C_1-6 alkyl group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

B represents a saturated or unsaturated 4 to 12 membered ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a (C═

O)—

OR¹⁰ group with R¹⁰ being a linear or branched C_1-6 alkyl group;

3) an A-X—

B—

Y—

C group,

wherein

A represents a saturated or unsaturated 4 to 18 membered ring system comprising 1 to 3 optionally condensed rings, in which additionally at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a (C═

O)—

OR¹⁰ group with R¹⁰ being a linear or branched C_1-6 alkyl group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

B represents a saturated or unsaturated 4 to 12 membered ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a (C═

O)—

OR¹⁰ group with R¹⁰ being a linear or branched C_1-6 alkyl group;

Y represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

C represents a saturated or unsaturated 4 to 12 membered ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃;

a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a (C═

O)—

OR¹⁰ group with R¹⁰ being a linear or branched C_1-6 alkyl group;

optionally in form of one of the stereoisomers, preferably enantiomers or diastereomers, a racemate or in form of a mixture of at least two of the stereoisomers, preferably enantiomers and/or diastereomers, in any mixing ratio, or a corresponding salt thereof, or a corresponding solvate thereof.

19. Compounds according to any of claim 1, characterized in that R¹ represents a branched or unbranched C_1-6-alkyl-aryl group wherein the C_1-6-alkyl and/or the aryl group is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a branched or unbranched C_1-6-alkyl-heteroaryl group wherein the C_1-6-alkyl and/or the aryl group is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a benzhydryl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a (SO₂)—

R⁶ group with R⁶ being an aryl group, preferably a phenyl or a naphtyl group, which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

a heteroaryl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

R² represents a methyl, ethyl, propyl or butyl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

or a benzyl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

R³ and R⁴, identical or different, represent a hydrogen atom;

a saturated or unsaturated, optionally at least mono-substituted C_3-8 aliphatic group with substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃, CN, nitro;

a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing cycloalkyl group with substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃, CN, nitro;

an unsubstituted heteroaryl group;

a saturated or unsaturated, optionally at least mono-substituted C_1-6 alkyl-cycloalkyl group;

a saturated or unsaturated, unsubstituted C_1-6 alkyl-aryl group;

a saturated or unsaturated, unsubstituted C_1-6 alkyl-heteroaryl group;

with the condition that R³ and R⁴ may not at the same time represent a hydrogen atom;

optionally in form of one of the stereoisomers, preferably enantiomers or diastereomers, a racemate or in form of a mixture of at least two of the stereoisomers, preferably enantiomers and/or diastereomers, in any mixing ratio, or a corresponding salt thereof, or a corresponding solvate thereof.

20. Compounds according to claim 1, characterized in that R¹ represents a branched or unbranched C_1-6-alkyl-aryl group wherein the C_1-6-alkyl and/or the aryl group is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a branched or unbranched C_1-6-alkyl-heteroaryl group wherein the C_1-6-alkyl and/or the aryl group is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a benzhydryl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a (SO₂)—

R⁶ group with R⁶ being an aryl group, preferably a phenyl or a naphtyl group, which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

a heteroaryl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

R² represents a hydrogen atom;

R³ and R⁴ together with their bridging nitrogen atom form

1) a 4 to 18 membered ring system A in which the ring containing the nitrogen atom is saturated, but may be condensed with an unsaturated ring, comprising 1 to 3 optionally condensed rings, in which additionally at least 1 carbon atom is optionally replaced by N or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃;

a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a (C═

O)—

OR¹⁰ group with R¹⁰ being a linear or branched C_1-6 alkyl group;

2) an A-X—

B group,

wherein

A represents a 4 to 18 membered ring system in which the ring containing the nitrogen atom is saturated, but may be condensed with an unsaturated ring, comprising 1 to 3 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃;

a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a (C═

O)—

OR¹⁰ group with R¹⁰ being a linear or branched C_1-6 alkyl group;

a (C═

O)—

OR¹⁰ group with R¹⁰ being a linear or branched C_1-6 alkyl group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

B represents a saturated or unsaturated 4 to 12 membered ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a (C═

O)—

OR¹⁰ group with R¹⁰ being a linear or branched C_1-6 alkyl group;

3) an A-X—

B—

Y—

C group,

wherein

A represents a 4 to 18 membered ring system in which the ring containing the nitrogen atom is saturated, but may be condensed with an unsaturated ring, comprising 1 to 3 optionally condensed rings, in which additionally at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a (C═

O)—

OR¹⁰ group with R¹⁰ being a linear or branched C_1-6 alkyl group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

B represents a saturated or unsaturated 4 to 12 membered ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a (C═

O)—

OR¹⁰ group with R¹⁰ being a linear or branched C_1-6 alkyl group;

Y represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

C represents a saturated or unsaturated 4 to 12 membered ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃;

a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a (C═

O)—

OR¹⁰ group with R¹⁰ being a linear or branched C_1-6 alkyl group;

optionally in form of one of the stereoisomers, preferably enantiomers or diastereomers, a racemate or in form of a mixture of at least two of the stereoisomers, preferably enantiomers and/or diastereomers, in any mixing ratio, or a corresponding salt thereof, or a corresponding solvate thereof.

21. Compounds according to claim 1, characterized in that R¹ represents a branched or unbranched C_1-6-alkyl-aryl group wherein the C_1-6-alkyl and/or the aryl group is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a branched or unbranched C_1-6-alkyl-heteroaryl group wherein the C_1-6-alkyl and/or the aryl group is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a benzhydryl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₃, CN, nitro, —

SO₂NH₂ or C_1-6-alkoxy;

a (SO₂)—

R⁶ group with R⁶ being an aryl group, preferably a phenyl or a naphtyl group, which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

a heteroaryl group which is optionally at least mono-substituted by substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

R² represents a hydrogen atom;

R³ represents a hydrogen atom;

R⁴ represents a saturated or unsaturated, unsubstituted, linear C_3-6 aliphatic group;

a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing 4 or 5-membered cycloalkyl group;

an unsubstituted heteroaryl group;

a saturated or unsaturated, unsubstituted alkyl-cycloalkyl group;

an unsubstituted C_1-6 alkyl-heteroaryl group;

optionally in form of one of the stereoisomers, preferably enantiomers or diastereomers, a racemate or in form of a mixture of at least two of the stereoisomers, preferably enantiomers and/or diastereomers, in any mixing ratio, or a corresponding salt thereof, or a corresponding solvate thereof.

22. Compounds according to claim 1, characterized in that R¹ represents a benzyl group or a (SO₂)—

R⁶ group with R⁶ being an aryl group;

R² represents a (C═

O)—

R⁸ group, with R⁸ representing a hydrogen atom;

a methyl group;

an ethyl group;

a propyl group;

a butyl group;

a pentyl group;

a hexyl group;

R³ and R⁴, identical or different, represent a C_3-8 alkyl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃, CN;

an optionally at least mono-substituted quinoline group;

a phenyl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃, CN;

a benzyl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃, CN;

or

R³ and R⁴ together with their bridging nitrogen atom form

1) a ring system A, comprising;

which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃;

a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a (C═

O)—

OR¹⁰ group with R¹⁰ being a linear or branched C_1-6 alkyl group;

2) an A-X—

B group,

wherein

A represents a ring system comprising;

which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃;

a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a (C═

O)—

OR¹⁰ group with R¹⁰ being a linear or branched C_1-6 alkyl group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a linear optionally substituted C_1-2 alkyl chain, —

O—

, or a —

SO₂—

group;

B represents an aryl group which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a naphtyl group which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

or a ring system comprising;

which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

3) an A-X—

B—

Y—

C group,

wherein

A represents a ring system comprising;

which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃;

a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a (C═

O)—

OR¹⁰ group with R¹⁰ being a linear or branched C_1-6 alkyl group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a linear C_1-2 alkyl chain, —

O—

, or a —

SO₂—

group;

B represents an aryl group which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a naphtyl group which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

or a ring system comprising;

which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

Y represents a bond, a —

NH—

group, a linear C_1-2-aliphatic group;

C represents an aryl group which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a naphtyl group which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

optionally in form of one of the stereoisomers, preferably enantiomers or diastereomers, a racemate or in form of a mixture of at least two of the stereoisomers, preferably enantiomers and/or diastereomers, in any mixing ratio, or a corresponding salt thereof, or a corresponding solvate thereof.

23. Compounds according to claim 1, characterized in that R¹ represents a benzyl group or a (SO₂)—

R⁶ group with R⁶ being an aryl group;

R² represents a methyl, ethyl, propyl or butyl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

or a benzyl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

R³ and R⁴ together with their bridging nitrogen atom form

1) a ring system A, comprising;

and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃;

a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a (C═

O)—

OR¹⁰ group with R¹⁰ being a linear or branched C_1-6 alkyl group;

2) an A-X—

B group,

wherein

A represents a ring system comprising;

which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃;

a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a (C═

O)—

OR¹⁰ group with R¹⁰ being a linear or branched C_1-6 alkyl group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a linear C_1-2 alkyl chain, —

O—

, or a —

SO₂—

group;

B represents an aryl group which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a naphtyl group which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

or a ring system comprising;

which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

3) an A-X—

B—

Y—

C group,

wherein

A represents a ring system comprising;

which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃;

a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a (C═

O)—

OR¹⁰ group with R¹⁰ being a linear or branched C_1-6 alkyl group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a linear C_1-2 alkyl chain, —

O—

, or a —

SO₂—

group;

B represents an aryl group which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a naphtyl group which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

or a ring system comprising;

which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

Y represents a bond, a —

NH—

group, a linear C_1-2 alkyl group;

C represents an aryl group which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a naphtyl group which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

optionally in form of one of the stereoisomers, preferably enantiomers or diastereomers, a racemate or in form of a mixture of at least two of the stereoisomers, preferably enantiomers and/or diastereomers, in any mixing ratio, or a corresponding salt thereof, or a corresponding solvate thereof.

24. Compounds according to claim 1, characterized in that R¹ represents a benzyl group or a (SO₂)—

R⁶ group with R⁶ being an aryl group;

R² represents a hydrogen atom;

R³ and R⁴ together with their bridging nitrogen atom form

1) a ring system A, comprising;

and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃;

a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a (C═

O)—

OR¹⁰ group with R¹⁰ being a linear or branched C_1-6 alkyl group;

2) an A-X—

B group,

wherein

A represents a ring system comprising;

which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃;

a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a (C═

O)—

OR¹⁰ group with R¹⁰ being a linear or branched C_1-6 alkyl group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a linear C_1-2 alkyl chain, —

O—

, or a —

SO₂—

group;

B represents an aryl group which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a naphtyl group which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

or a ring system comprising;

which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

3) an A-X—

B—

Y—

C group,

wherein

A represents a ring system comprising;

which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃;

a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a (C═

O)—

OR¹⁰ group with R¹⁰ being a linear or branched C_1-6 alkyl group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a linear C_1-2 alkyl chain, —

O—

, or a —

SO₂—

group;

B represents an aryl group which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a naphtyl group which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

or a ring system comprising;

which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6 alkoxy group;

Y represents a bond, a —

NH—

group, a linear C_1-2-alkyl group;

C represents an aryl group which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a naphtyl group which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

optionally in form of one of the stereoisomers, preferably enantiomers or diastereomers, a racemate or in form of a mixture of at least two of the stereoisomers, preferably enantiomers and/or diastereomers, in any mixing ratio, or a corresponding salt thereof, or a corresponding solvate thereof.

25. Compounds according to claim 1 selected from the group consisting of

[1] (3,4-trans)-1-benzyl-4-(3,4-dihydroisoquinolin-2(1H)-yl)pyrrolidine-3-ol,

[2] (3,4-trans)-1-benzyl-4-morpholinopyrrolidine-3-ol,

[3] (3,4-trans)-1-benzyl-4-(4-(2-methyl-3H-imidazo[4,5-b]pyridin-3-yl)piperidin-1-yl)pyrrolidine-3-ol,

[4] (3,4-trans)-1-benzyl-4-(3-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)propyl amino)pyrrolidine-3-ol,

[5] (3,4-trans)-1-benzyl-4-(4-((3,4-dihydroisoquinolin-2(1H)-yl)methyl)piperidin-1-yl)pyrrolidine-3-ol,

[6] 1-(4-(6-((3,4-trans)-1-benzyl-4-hydroxypyrrolidine-3-yl)-5,6,7,8-tetrahydropyrido [4,3-d]pyrimidin-2-ylamino)phenyl)ethanone,

[7] 1-(1-((3,4-trans)-1-benzyl-4-hydroxypyrrolidine-3-yl)piperidin-4-yl)-1H-benzo[d] [1,3] oxazin-2(4H)-one,

[8] (3,4-trans)-1-benzyl-4-(2-(4-phenoxyphenylamino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)pyrrolidine-3-ol,

[9] (3,4-trans)-1-benzyl-4-(3-(3,4-dihydroisoquinolin-2(1H)-yl)propylamino)pyrrolidine -3-ol,

[10] (3,4-trans)-1-benzyl-4-(4-(4-methoxypyrimidin-2-yl)piperazin-1-yl)pyrrolidine-3-ol,

[11] (3,4-trans)-1-benzyl-4-(2,3,8,8a-tetrahydrocyclopenta[ij]isoquinolin-1(7H)-yl)pyrrolidine-3-ol,

[12] tert-butyl-4-((3,4-trans)-1-benzyl-4-hydroxypyrrolidine-3-yl)piperazine-1-carboxylate,

[13] tert-butyl 4-((3,4-trans)-4-hydroxy-1-(phenylsulfonyl)pyrrolidine-3-yl)piperazine-1-carboxylate,

[14] (3,4-trans)-4-morpholino-1-(phenylsulfonyl)pyrrolidine-3-ol,

[15] (3,4-trans)-4-(3,4-dihydroisoquinolin-2(1H)-yl)-1-(phenylsulfonyl)pyrrolidine-3-ol,

[16] (3,4-trans)-4-(3,4-dihydroisoquinolin-2(1H)-yl)-1((S)-I-phenylethyl)pyrrolidine-3-ol,

[17] (3,4-trans)-1-benzyl-4-(4-benzylpiperazin-1-yl)pyrrolidine-3-ol,

[18] (3,4-trans)-1-benzyl-4-(4-phenylpiperazin-1-yl)pyrrolidine-3-ol,

[19] Ethyl 2-(4-((3,4-trans)-1-benzyl-4-hydroxypyrrolidine-3-yl)piperazin-1-yl)acetate,

[20] (4-((3,4-trans)-1-benzyl-4-hydroxypyrrolidine-3-yl)piperazin-1-yl)(phenyl)methanone,

[21] Ethyl 4-((3,4-trans)-1-benzyl-4-hydroxypyrrolidine-3-yl)piperazine-1-carboxilate,

[22] tert-butyl 4-((3,4-trans)-1-(4-fluorobenzyl)-4-hydroxypyrrolidine-3-yl)piperazine-1-carboxylate,

[23] (3,4-trans)-1-benzyl-4-(4-methylpiperazin-1-yl)pyrrolidine-3-ol,

[24] tert-butyl-4-(3,4-trans)-4-acetoxy-1-benzylpyrrolidine-3-yl)piperazine-1-carboxylate,

[25] (3,4-trans)-1-benzyl-4-(piperazin-1-yl)pyrrolidine-3-yl acetate,

[26] tert-butyl 4-((3,4-trans)-4-acetoxypyrrolidine-3-yl)piperazine-1-carboxylate,

[27] trans 1-Benzyl-4-(4-(2-phenyl-phenylsulfonyl)piperazin-1-yl)pyrrolidin-3-yl acetate,

[28] trans 1-Benzyl-4-(4-(2-phenyl-phenylsulfonyl)piperazin-1-yl)pyrrolidin-3-ol dihydrochloride,

[29] (3,4-trans)-1-benzyl-4-(phenylamino)pyrrolidin-3-ol,

[30] (3,4-trans)-1-benzyl-4-(benzylamino)pyrrolidin-3-ol,

[31] (3R,4R)-1-benzyl-4-(octylamino)pyrrolidin-3-ol,

[32] (3,4-trans)-1-benzyl-4-(4-methoxybenzylamino)pyrrolidin-3-ol,

[33] (3,4-trans)-1-benzyl-4-(butylamino)pyrrolidin-3-ol,

[34] (3R,4R)-1-benzyl-4-(4-(4-chloro-2,5-dimethylphenylsulfonyl)piperazin-1-yl)pyrrolidin-3-yl acetate,

[35] (3R,4R)-1-benzyl-4-(4-tosylpiperazin-1-yl)pyrrolidin-3-yl acetate,

[36] (3,4-trans)-1-benzyl-4-(butylamino)pyrrolidin-3-ol,

[37] (3R,4R)-1-benzyl-4-(4-methoxyphenylamino)pyrrolidin-3-ol,

[38] Methyl 4-((3,4-trans)-1-benzyl-4-hydroxypyrrolidin-3-ylamino)benzoate,

[39] (3R,4R)-1-benzyl-4-(4-(naphthalen-1-ylsulfonyl)piperazin-1-yl)pyrrolidin-3-yl acetate,

[40] (3R,4R)-1-benzyl-4-(4-(2-chlorophenylsulfonyl)piperazin-1-yl)pyrrolidin-3-ol,

[41] (3R,4R)-1-benzyl-4-(4-(2-bromophenylsulfonyl)piperazin-1-yl)pyrrolidin-3-yl acetate,

[42] (3R,4R)-1-benzyl-4-(4-(2-bromophenylsulfonyl)piperazin-1-yl)pyrrolidin-3-ol,

[43] (3R,4R)-1-benzyl-4-(4-(5-fluoro-2-methylphenylsulfonyl)piperazin-1-yl)pyrrolidin-3-yl acetate,

[44] (3R,4R)-1-benzyl-4-(4-(5-fluoro-2-methylphenylsulfonyl)piperazin-1-yl)pyrrolidin-3-ol,

[45] (3R,4R)-1-benzyl-4-(4-(phenylsulfonyl)piperazin-1-yl)pyrrolidin-3-yl acetate,

[46] (3R,4R)-1-benzyl-4-(4-(phenylsulfonyl)piperazin-1-yl)pyrrolidin-3-ol,

[47] (3R,4R)-1-benzyl-4-(4-(2-fluorophenylsulfonyl)piperazin-1-yl)pyrrolidin-3-yl acetate,

[48] (3R,4R)-1-benzyl-4-(4-(2-fluorophenylsulfonyl)piperazin-1-yl)pyrrolidin-3-ol,

[49] (3R,4R)-1-benzyl-4-(4-(naphthalen-1-ylsulfonyl)piperazin-1-yl)pyrrolidin-3-ol,

[50] (3R,4R)-1-benzyl-4-(4-(4-chloro-2,5-dimethylphenylsulfonyl)piperazin-1-yl)pyrrolidin-3-ol,

[51] (3R,4R)-1-benzyl-4-(4-tosylpiperazin-1-yl)pyrrolidin-3-ol,

[52] (3R,4R)-1-benzyl-4-(4-(2-chlorophenylsulfonyl)piperazin-1-yl)pyrrolidin-3-yl acetate,

[53] (3,4-trans)-1-benzyl-4-(4-(4-chloro-2,5-dimethylphenylsulfonyl)piperazin-1-yl)pyrrolidin-3-yl acetate dihydrochloride,

[54] (3,4-trans)-1-benzyl-4-(4-(4-chloro-2,5-dimethylphenylsulfonyl)piperazin-1-yl)pyrrolidin-3-ol dihydrochloride,

[55] (3S,4S)-1-benzyl-4-(4-(4-chloro-2,5-dimethylphenylsulfonyl)piperazin-1-yl)pyrrolidin-3-ol dihydrochloride,

[56] (3,4-trans)-1-benzyl-4-(4-tosylpiperazin-1-yl)pyrrolidin-3-yl acetate dihydrochloride,

[57] (3,4-trans)-1-benzyl-4-(4-tosylpiperazin-1-yl)pyrrolidin-3-ol dihydrochloride,

[58] (3R,4R)-1-benzyl-4-(4-tosylpiperazin-1-yl)pyrrolidin-3-ol dihydorchloride,

[59] (3S,4S)-1-benzyl-4-(4-tosylpiperazin-1-yl)pyrrolidin-3-ol dihydrochloride,

[60] (3,4-trans)-1-benzyl-4-(4-(naphthalen-1-ylsulfonyl)piperazin-1-yl)pyrrolidin-3-yl acetate dihydrochloride,

[61] (3,4-trans)-1-benzyl-4-(4-(naphthalen-1-ylsulfonyl)piperazin-1-yl)pyrrolidin-3-ol dihydrochloride,

[62] (3S-4S)-1-benzyl-4-(4-(naphthalen-1-ylsulfonyl)piperazin-1-yl)pyrrolidin-3-ol dihydrochloride,

[63] (3,4-trans)-1-benzyl-4-(4-(2-chlorophenylsulfonyl)piperazin-1-yl)pyrrolidin-3-yl acetate dihydrochloride,

[64] (3,4-trans)-1-benzyl-4-(4-(2-chlorophenylsulfonyl)piperazin-1-yl)pyrrolidin-3-ol dihydrochloride,

[65] (3S,4S)-1-benzyl-4-(4-(2-chlorophenylsulfonyl)piperazin-1-yl)pyrrolidin-3-ol dihydrochloride,

[66] (3,4-trans)-1-benzyl-4-(4-(2-bromophenylsulfonyl)piperazin-1-yl)pyrrolidin-3-yl acetate dihydrochloride,

[67] (3,4-trans)-1-benzyl-4-(4-(2-bromophenylsulfonyl)piperazin-1-yl)pyrrolidin-3-ol dihydrochloride,

[68] (3S,4S)-1-benzyl-4-(4-(2-bromophenylsulfonyl)piperazin-1-yl)pyrrolidin-3-ol dihydrochloride,

[69] (3,4-trans)-1-benzyl-4-(4-(5-fluoro-2-methylphenylsulfonyl)piperazin-1-yl)pyrrolidin-3-yl acetate dihydrochloride,

[70] (3,4-trans)-1-benzyl-4-(4-(5-fluoro-2-methylphenylsulfonyl)piperazin-1-yl)pyrrolidin-3-ol dihydrochloride,

[71] (3S,4S)-1-benzyl-4-(4-(5-fluoro-2-methylphenylsulfonyl)piperazin-1-yl)pyrrolidin-3-ol dihydrochloride,

[72] (3,4-trans)-1-benzyl-4-(4-(phenylsulfonyl)piperazin-1-yl)pyrrolidin-3-yl acetate,

[73] (3,4-trans)-1-benzyl-4-(4-(phenylsulfonyl)piperazin-1-yl)pyrrolidin-3-ol,

[74] (3S,4S)-1-benzyl-4-(4-(phenylsulfonyl)piperazin-1-yl)pyrrolidin-3-ol,

[75] (3,4-trans)-1-benzyl-4-(4-(2-fluorophenylsulfonyl)piperazin-1-yl)pyrrolidin-3-yl acetate dihydrochloride,

[76] (3,4-trans)-1-benzyl-4-(4-(2-fluorophenylsulfonyl)piperazin-1-yl)pyrrolidin-3-ol dihydrochloride,

[77] (3S,4S)-1-benzyl-4-(4-(2-fluorophenylsulfonyl)piperazin-1-yl)pyrrolidin-3-ol dihydrochloride,

[78] (3,4-trans)-1-benzyl-4-(4-(2-chloro-6-fluorobenzyl)piperazin-1-yl)pyrrolidine-3-ol

[79] (3,4-trans)-1-benzyl-4-(4-(3,4-dichlorobenzyl)piperazin-1-yl)pyrrolidine-3-ol

[80] (3,4-trans)-1-benzyl-4-hydroxypyrrolidin-3-yl)piperazin-1-yl)(furan-2-yl)methanone

[81] (3,4-trans)-1-benzyl-4-(4-ethylpiperazin-1-yl)pyrrolidin-3-ol,

[82] (3,4-trans)-1-benzyl-4-(4-(2-methoxyphenyl)piperazin-1-yl)pyrrolidin-3-ol,

[83] (3,4-trans)-1-benzyl-4-(4-(4-fluorophenyl)piperazin-1-yl)pyrrolidin-3-ol,

[84] (3,4-trans)-1-benzyl-4-(4-(2-chlorophenyl)piperazin-1-yl)pyrrolidin-3-ol,

[85] (3R,4R)-1-benzyl-4-(4-(2-chlorophenyl)piperazin-1-yl)pyrrolidin-3-ol,

[86] (35,45)-1-benzyl-4-(4-(2-chlorophenyl)piperazin-1-yl)pyrrolidin-3-ol,

[87] 1-(4-((3,4-trans)-1-benzyl-4-hydroxypyrrolidin-3-yl)piperazin-1-yl)ethanone,

[88] (3,4-trans)-1-benzyl-4-(4-(3,4-dichlorophenyl)piperazin-1-yl)pyrrolidin-3-ol,

[89] (3,4-trans)-1-benzyl-4-(4-(3,4-dichlorophenyl)piperazin-1-yl)pyrrolidin-3-ol,

or

[90] (3,4-trans)-cert-butyl 3-(3,4-dihydroisoquinolin-2(1H)-yl)-4-hydroxypyrrolidine-1-carboxylate;

optionally in form of a corresponding salt, or a corresponding solvate.

26. Substituted pyrrolidine compounds according to claim 1 of general formula (IA),

wherein

Z represents H or CH₃;

R² represents a hydrogen atom;

a substituted or unsubstituted aliphatic group;

a (C═

O)—

R⁸ group;

a benzyl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH;

R³ and R⁴, equal or different, represent a hydrogen atom;

an unbranched or branched, saturated or unsaturated, optionally at least mono-substituted aliphatic radical;

a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing cycloalkyl group, which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing alkyl-cycloalkyl group in which the cycloalkyl group may be optionally at least mono-substituted;

an optionally at least mono-substituted aryl group which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

an optionally at least mono-substituted heteroaryl group which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-aryl group in which the aryl group may be optionally at least mono-substituted and/or condensed with a mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-heteroaryl group in which the heteroaryl group may be optionally at least mono-substituted and/or condensed with a mono- or polycyclic ring system;

with the condition (proviso) that R³ and R⁴ may not at the same time represent a hydrogen atom;

or

R³ and R⁴ together with their bridging nitrogen atom form

1) a saturated or unsaturated ring system A, comprising 1 to 3 optionally condensed rings, in which additionally at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, N11₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹⁰ group;

or a (C═

O)—

NR¹²R^12a group;

2) an A-X—

B group,

wherein

A represents a saturated or unsaturated ring system comprising 1 to 3 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

B represents a saturated or unsaturated ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

3) an A-X—

B—

Y—

C group,

wherein

A represents a saturated or unsaturated ring system comprising 1 to 3 optionally condensed rings, in which additionally at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

B represents a saturated or unsaturated ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

Y represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

C represents a saturated or unsaturated ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

R⁸ represents a hydrogen atom;

a branched or unbranched, saturated or unsaturated, unsubstituted aliphatic group;

R⁹, R¹⁰ and R¹¹ represent a hydrogen atom, an unbranched or branched, saturated or unsaturated, optionally at least mono-substituted aliphatic radical;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing alkyl-cycloalkyl group;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-aryl group in which the aryl group may be condensed with a mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-heteroaryl group in which the heteroaryl group may be condensed with a mono- or polycyclic ring system;

R¹² and R^12a, identical or different, represent a hydrogen atom, an unbranched or branched, saturated or unsaturated, optionally at least mono-substituted aliphatic radical;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing alkyl-cycloalkyl group;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-aryl group in which the aryl group may be condensed with a mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-heteroaryl group in which the heteroaryl group may be condensed with a mono- or polycyclic ring system;

W represents F, Cl, Br, I, NH₂, SH, OH, SO₂, CF₂, carboxy, amido, cyano, carbamyl, nitro, phenyl, benzyl, —

SO₂NH₂, C_1-6 alkyl and/or C_1-6-alkoxy;

r represents either 0, 1, 2 or 3;

with the provisos that

if R² represents a hydrogen atom;

R³ and R⁴ may not form together with their bridging nitrogen atom a triazole group;

if R² represents a hydrogen atom;

R³ and R⁴ may not form together with their bridging nitrogen atom a substituted, unsaturated, condensed ring system containing at least 4 nitrogen atoms as ring members;

an unsaturated, (C═

O)-substituted, uncondensed, 6-membered ring system in which one additional carbon atom is replaced by nitrogen.

if R² represents a hydrogen atom;

and either R³ or R⁴ represents a hydrogen atom;

the other of R³ or R⁴ may not represent a substituted or unsubstituted C_1-2alkyl group;

an unsubstituted benzyl group;

a C_3-8 substituted alkyl group;

a substituted alkyl-aryl group;

or

R³ or R⁴, together with their bridging nitrogen atom may not form a a tetrahydropyrimidine ring;

a triazolo pyrimidine ring;

optionally in form of one of the stereoisomers, preferably enantiomers or diastereomers, a racemate or in form of a mixture of at least two of the stereoisomers, preferably enantiomers and/or diastereomers, in any mixing ratio, or a corresponding salt thereof, or a corresponding solvate thereof.

27. Substituted pyrrolidine compounds according to claim 26

wherein

Z represents H or CH₃;

preferably Z represents H;

R² represents a hydrogen atom;

a methyl, ethyl, propyl or butyl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

a (C═

O)—

R⁸ group, with R⁸ representing a hydrogen atom;

a methyl group;

an ethyl group;

a propyl group;

a butyl group;

a pentyl group;

a hexyl group;

or a benzyl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

preferably R² represents a hydrogen atom;

a (C═

O)—

R⁸ group, with R⁸ representing a hydrogen atom;

a methyl group;

an ethyl group;

a propyl group;

a butyl group;

a pentyl group;

a hexyl group

R³ and R⁴, identical or different, represent a hydrogen atom;

a saturated or unsaturated, unsubstituted C_3-8 aliphatic group;

a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing cycloalkyl group;

an unsubstituted heteroaryl group;

a saturated or unsaturated, optionally at least mono-substituted alkyl-cycloalkyl group;

an unsubstituted alkyl-aryl group;

a saturated or unsaturated, optionally at least mono-substituted alkyl-heteroaryl group;

with the condition that R³ and R⁴ may not at the same time represent a hydrogen atom;

or

R³ and R⁴ together with their bridging nitrogen atom form

1) a ring system A, comprising;

and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃;

a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a (C═

O)—

OR¹⁰ group with R¹⁰ being a linear or branched C_1-6 alkyl group;

2) an A-X—

B group,

wherein

A represents a ring system comprising;

which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃;

a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a (C═

O)—

OR¹⁰ group with R¹⁰ being a linear or branched C_1-6 alkyl group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a linear C_1-2 alkyl chain, —

O—

, or a —

SO₂—

group;

B represents an aryl group which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a naphtyl group which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

or a ring system comprising;

which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

3) an A-X—

B—

Y—

C group,

wherein

A represents a ring system comprising;

which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃;

a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a (C═

O)—

OR¹⁰ group with R¹⁰ being a linear or branched C_1-6 alkyl group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a linear C_1-2 alkyl chain, —

O—

, or a —

SO₂—

group;

B represents an aryl group which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a naphtyl group which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

or a ring system comprising;

which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6 alkoxy group;

Y represents a bond, a —

NH—

group, a linear C_1-2-alkyl group;

C represents an aryl group which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a naphtyl group which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

R⁸ represents a hydrogen atom;

a branched or unbranched, saturated or unsaturated, unsubstituted aliphatic group;

R⁹, R¹⁰ and R¹¹ represent a hydrogen atom, an unbranched or branched, saturated or unsaturated, optionally at least mono-substituted aliphatic radical;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing alkyl-cycloalkyl group;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-aryl group in which the aryl group may be condensed with a mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-heteroaryl group in which the heteroaryl group may be condensed with a mono- or polycyclic ring system;

R¹² and R^12a, identical or different, represent a hydrogen atom, an unbranched or branched, saturated or unsaturated, optionally at least mono-substituted aliphatic radical;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing alkyl-cycloalkyl group;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-aryl group in which the aryl group may be condensed with a mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-heteroaryl group in which the heteroaryl group may be condensed with a mono- or polycyclic ring system;

W represents substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃, OCF₃, unsubstituted C_1-6alkyl and/or unsubstituted C_1-6-alkoxy;

r represents either 0, 1, 2 or 3;

with the provisos that

if R² represents a hydrogen atom;

R³ and R⁴ may not form together with their bridging nitrogen atom a triazole group;

a substituted, unsaturated, condensed ring system containing at least 4 nitrogen atoms as ring members;

an unsaturated, (C═

O)—

substituted, uncondensed, 6-membered ring system in which one additional carbon atom is replaced by nitrogen;

or may not form a tetrahydropyrimidine ring;

a triazolo pyrimidine ring

if R² represents a hydrogen atom;

and either R³ or R⁴ represents a hydrogen atom;

the other of R³ or R⁴ may not represent a substituted or unsubstituted C_1-2 alkyl group;

an unsubstituted benzyl group;

a C_3-8 substituted alkyl group;

a substituted alkyl-aryl group;

optionally in form of one of the stereoisomers, preferably enantiomers or diastereomers, a racemate or in form of a mixture of at least two of the stereoisomers, preferably enantiomers and/or diastereomers, in any mixing ratio, or a corresponding salt thereof, or a corresponding solvate thereof.

28. Substituted pyrrolidine compounds according to claim 27, according to either formula (IAa) or (IAb)

wherein

R² represents a hydrogen atom;

a methyl, ethyl, propyl or butyl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

a (C═

O)—

R⁸ group, with R⁸ representing a hydrogen atom;

a methyl group;

an ethyl group;

a propyl group;

a butyl group;

a pentyl group;

a hexyl group;

or a benzyl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

preferably R² represents hydrogen or (C═

O)—

CH₃;

R⁴,—

if present as in case of general formula (IAb)—

represents a saturated or unsaturated, unsubstituted C_3-8 aliphatic group;

a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing cycloalkyl group;

an unsubstituted heteroaryl group;

a saturated or unsaturated, optionally at least mono-substituted alkyl-cycloalkyl group;

an unsubstituted alkyl-aryl group;

a saturated or unsaturated, optionally at least mono-substituted alkyl-heteroaryl group;

or

Q—

if present as in case of general formula (IAa)—

represents N or CH, preferably Q represents N; and

Rx—

if present as in case of general formula (IAa)—

represents

hydrogen;

a —

(C═

O)R⁸ group with R⁸ being either hydrogen or an optionally substituted C_1-6 aliphatic group;

or a —

(C═

O)OR¹⁰ group with R¹⁰ being either hydrogen or an optionally substituted C_1-6 aliphatic group;

or X—

B with

X representing a bond, an —

NH—

group, a —

(C═

O)—

group, a linear C_1-2 alkyl chain, —

O—

, —

S—

or an —

SO₂—

group;

preferably X represents a bond or SO₂; and

B representing a phenyl group which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a naphtyl group which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

or a ring system selected from a heterocyclyl, preferably from;

which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

W represents substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃, OCF₃, unsubstituted C_1-6alkyl and/or unsubstituted C_1-6-alkoxy;

preferably represents H;

r represents either 0, 1, 2 or 3;

preferably is 0;

with the proviso that

if in a compound according to general formula (IAb) R² represents a hydrogen atom;

R⁴ may not represent a substituted or unsubstituted C_1-2alkyl group;

an unsubstituted benzyl group;

a C_3-8 substituted alkyl group;

a substituted alkyl-aryl group;

optionally in form of one of the stereoisomers, preferably enantiomers or diastereomers, a racemate or in form of a mixture of at least two of the stereoisomers, preferably enantiomers and/or diastereomers, in any mixing ratio, or a corresponding salt thereof, or a corresponding solvate thereof.

29. Substituted pyrrolidine compounds according to claim 1 of general formula (IB),

wherein

R² represents a hydrogen atom;

a substituted or unsubstituted aliphatic group;

a (C═

O)—

R⁸ group;

a benzyl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH;

R³ and R⁴, equal or different, represent a hydrogen atom;

an unbranched or branched, saturated or unsaturated, optionally at least mono-substituted aliphatic radical;

a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing cycloalkyl group, which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing alkyl-cycloalkyl group in which the cycloalkyl group may be optionally at least mono-substituted;

an optionally at least mono-substituted aryl group which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

an optionally at least mono-substituted heteroaryl group which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-aryl group in which the aryl group may be optionally at least mono-substituted and/or condensed with a mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-heteroaryl group in which the heteroaryl group may be optionally at least mono-substituted and/or condensed with a mono- or polycyclic ring system;

with the condition (proviso) that

R³ and R⁴ may not at the same time represent a hydrogen atom;

or

R³ and R⁴ together with their bridging nitrogen atom form

1) a saturated or unsaturated ring system A, comprising 1 to 3 optionally condensed rings, in which additionally at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

2) an A-X—

B group,

wherein

A represents a saturated or unsaturated ring system comprising 1 to 3 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

B represents a saturated or unsaturated ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹⁰ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

3) an A-X—

B—

Y—

C group,

wherein

A represents a saturated or unsaturated ring system comprising 1 to 3 optionally condensed rings, in which additionally at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

B represents a saturated or unsaturated ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

Y represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

C represents a saturated or unsaturated ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

R⁶ represents a hydrogen atom, an unbranched or branched, saturated or unsaturated, optionally at least mono-substituted aliphatic radical;

a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing cycloalkyl group, which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing alkyl-cycloalkyl group;

an optionally at least mono-substituted aryl group which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

an optionally at least mono-substituted heteroaryl group which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-aryl group in which the aryl group may be condensed with a mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-heteroaryl group in which the heteroaryl group may be condensed with a mono- or polycyclic ring system;

R⁸ represents a hydrogen atom;

a branched or unbranched, saturated or unsaturated, unsubstituted aliphatic group;

R⁹, R¹⁰ and R¹¹ represent a hydrogen atom, an unbranched or branched, saturated or unsaturated, optionally at least mono-substituted aliphatic radical;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing alkyl-cycloalkyl group;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-aryl group in which the aryl group may be condensed with a mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-heteroaryl group in which the heteroaryl group may be condensed with a mono- or polycyclic ring system;

R¹² and R^12a, identical or different, represent a hydrogen atom, an unbranched or branched, saturated or unsaturated, optionally at least mono-substituted aliphatic radical;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted, Optionally at least one heteroatom as ring member containing alkyl-cycloalkyl group;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-aryl group in which the aryl group may be condensed with a mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-heteroaryl group in which the heteroaryl group may be condensed with a mono- or polycyclic ring system;

optionally in form of one of the stereoisomers, preferably enantiomers or diastereomers, a racemate or in form of a mixture of at least two of the stereoisomers, preferably enantiomers and/or diastereomers, in any mixing ratio, or a corresponding salt thereof, or a corresponding solvate thereof.

30. Substituted pyrrolidine compounds according to claim 29,

wherein

R² represents a hydrogen atom;

a methyl, ethyl, propyl or butyl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

a (C═

O)—

R⁸ group, with R⁸ representing a hydrogen atom;

a methyl group;

an ethyl group;

a propyl group;

a butyl group;

a pentyl group;

a hexyl group;

or a benzyl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH, CF₃;

preferably R² represents a hydrogen atom;

a (C═

O)—

R⁸ group, with R⁸ representing a hydrogen atom;

a methyl group;

an ethyl group;

a propyl group;

a butyl group;

a pentyl group;

a hexyl group

R³ and R⁴, identical or different, represent a hydrogen atom;

a saturated or unsaturated, unsubstituted C_3-8 aliphatic group;

a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing cycloalkyl group;

an unsubstituted heteroaryl group;

a saturated or unsaturated, optionally at least mono-substituted alkyl-cycloalkyl group;

an unsubstituted alkyl-aryl group;

a saturated or unsaturated, optionally at least mono-substituted alkyl-heteroaryl group;

with the condition that R³ and R⁴ may not at the same time represent a hydrogen atom;

or

R³ and R⁴ together with their bridging nitrogen atom form

1) a ring system A, comprising;

and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃;

a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a (C═

O)—

OR¹⁰ group with R¹⁰ being a linear or branched C_1-6 alkyl group;

2) an A-X—

B group,

wherein

A represents a ring system comprising;

which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃;

a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a (C═

O)—

OR¹⁰ group with R¹⁰ being a linear or branched C_1-6 alkyl group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a linear C_1-2 alkyl chain, —

O—

, or a —

SO₂—

group;

B represents an aryl group which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a naphtyl group which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

or a ring system comprising;

which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

3) an A-X—

B—

Y—

C group,

wherein

A represents a ring system comprising;

which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃;

a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a (C═

O)—

OR¹⁰ group with R¹⁰ being a linear or branched C_1-6 alkyl group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a linear C_1-2 alkyl chain, —

O—

, or a —

SO₂—

group;

B represents an aryl group which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a naphtyl group which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

or a ring system comprising;

which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6 alkoxy group;

Y represents a bond, a —

NH—

group, a linear C_1-2-alkyl group;

C represents an aryl group which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

a naphtyl group which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkoxy group;

R⁶ represent an optionally at least mono-substituted aryl group which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

an optionally at least mono-substituted heteroaryl group which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

preferably represents an optionally at least mono-substituted aryl group;

R⁸ represents a hydrogen atom;

a branched or unbranched, saturated or unsaturated, unsubstituted aliphatic group;

R⁹, R¹⁰ and R¹¹ represent a hydrogen atom, an unbranched or branched, saturated or unsaturated, optionally at least mono-substituted aliphatic radical;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing alkyl-cycloalkyl group;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-aryl group in which the aryl group may be condensed with a mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-heteroaryl group in which the heteroaryl group may be condensed with a mono- or polycyclic ring system;

R¹² and R^12a, identical or different, represent a hydrogen atom, an unbranched or branched, saturated or unsaturated, optionally at least mono-substituted aliphatic radical;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing alkyl-cycloalkyl group;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-aryl group in which the aryl group may be condensed with a mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-heteroaryl group in which the heteroaryl group may be condensed with a mono- or polycyclic ring system;

optionally in form of one of the stereoisomers, preferably enantiomers or diastereomers, a racemate or in form of a mixture of at least two of the stereoisomers, preferably enantiomers and/or diastereomers, in any mixing ratio, or a corresponding salt thereof, or a corresponding solvate thereof.

31. Substituted pyrrolidine compounds according to claim 1 according to general formula (I),

wherein

R¹ represents H or C(O)OCH₃;

R² represents a hydrogen atom;

a substituted or unsubstituted aliphatic group;

a (C═

O)—

R⁸ group;

a benzyl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH;

R³ and R⁴, equal or different, represent a hydrogen atom;

an unbranched or branched, saturated or unsaturated, optionally at least mono-substituted aliphatic radical;

a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing cycloalkyl group, which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing alkyl-cycloalkyl group in which the cycloalkyl group may be optionally at least mono-substituted;

an optionally at least mono-substituted aryl group which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

an optionally at least mono-substituted heteroaryl group which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-aryl group in which the aryl group may be optionally at least mono-substituted and/or condensed with a mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-heteroaryl group in which the heteroaryl group may be optionally at least mono-substituted and/or condensed with a mono- or polycyclic ring system;

with the condition (proviso) that R³ and R⁴ may not at the same time represent a hydrogen atom;

or

R³ and R⁴ together with their bridging nitrogen atom form

1) a saturated or unsaturated ring system A, comprising 1 to 3 optionally condensed rings, in which additionally at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

2) an A-X—

B group,

wherein

A represents a saturated or unsaturated ring system comprising 1 to 3 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

B represents a saturated or unsaturated ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

3) an A-X—

B—

Y—

C group,

wherein

A represents a saturated or unsaturated ring system comprising 1 to 3 optionally condensed rings, in which additionally at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹⁰ group;

or a (C═

O)—

NR¹²R^12a group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

B represents a saturated or unsaturated ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

Y represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

C represents a saturated or unsaturated ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

R⁸ represents a hydrogen atom;

a branched or unbranched, saturated or unsaturated, unsubstituted aliphatic group;

R⁹, R¹⁰ and R¹¹ represent a hydrogen atom, an unbranched or branched, saturated or unsaturated, optionally at least mono-substituted aliphatic radical;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing alkyl-cycloalkyl group;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-aryl group in which the aryl group may be condensed with a mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-heteroaryl group in which the heteroaryl group may be condensed with a mono- or polycyclic ring system;

R¹² and R^12a, identical or different, represent a hydrogen atom, an unbranched or branched, saturated or unsaturated, optionally at least mono-substituted aliphatic radical;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing alkyl-cycloalkyl group;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-aryl group in which the aryl group may be condensed with a mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-heteroaryl group in which the heteroaryl group may be condensed with a mono- or polycyclic ring system;

32. A process for the manufacture of substituted pyrrolidine compounds of general formula (I) according to claim 1, characterized in that at least one pyrroline compound of general formula (II),

wherein R¹ has the meaning given above, is reacted with a per-acid, preferably MCPBA to form a compound of general formula (III),

wherein R¹ has the meaning given above, followed by reacting the epoxyo-pyrroline compound of formula III with a compound of formula (IV)

together with LiClO₄, ACN at preferably 90°

C. to give a compound of formula I, in which R² is H;

alternatively followed by reacting the pyrrolidine compound of formula I with a base to give a compound of formula I, in which R² has the meaning according to claim 1.

33. A medicament comprising at least one substituted pyrrolidine compound of general formula (I) according to claim 1,

wherein

R¹ represents a hydrogen atom, an unbranched or branched, saturated, optionally at least mono-substituted C_1-6-aliphatic radical;

a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing cycloalkyl group, which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing alkyl-cycloalkyl group in which the cycloalkyl group may be optionally at least mono-substituted;

an optionally at least mono-substituted aryl group which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

an optionally at least mono-substituted heteroaryl group which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

a branched or unbranched, optionally at least mono-substituted alkyl-aryl group in which the aryl group may be optionally at least mono-substituted and/or condensed with a mono- or polycyclic ring system;

a branched or unbranched, saturated, optionally at least mono-substituted alkyl-heteroaryl group in which the heteroaryl group may be optionally at least mono-substituted and/or condensed with a mono- or polycyclic ring system;

an optionally at least mono-substituted benzhydryl group;

a (C═

O)—

R⁵ group;

a group;

a (SO₂)—

R⁶ group;

or a (C═

O)—

NR⁷R^7a group;

R² represents a hydrogen atom;

a substituted or unsubstituted aliphatic group;

a (C═

O)—

R⁸ group;

a benzyl group which is optionally substituted by one or more substituents independently selected from the group consisting of F, Cl, Br, I, NH₂, SH, OH;

R³ and R⁴, equal or different, represent a hydrogen atom;

an unbranched or branched, saturated or unsaturated, optionally at least mono-substituted aliphatic radical;

a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing cycloalkyl group, which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing alkyl-cycloalkyl group in which the cycloalkyl group may be optionally at least mono-substituted;

an optionally at least mono-substituted aryl group which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

an optionally at least mono-substituted heteroaryl group which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-aryl group in which the aryl group may be optionally at least mono-substituted and/or condensed with a mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-heteroaryl group in which the heteroaryl group may be optionally at least mono-substituted and/or condensed with a mono- or polycyclic ring system;

with the condition (proviso) that R³ and R⁴ may not at the same time represent a hydrogen atom;

or

R³ and R⁴ together with their bridging nitrogen atom form

1) a saturated or unsaturated ring system A, comprising 1 to 3 optionally condensed rings, in which additionally at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Br, I, NH₂, SH, OH₁ CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

2) an A-X—

B group,

wherein

A represents a saturated or unsaturated ring system comprising 1 to 3 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

B represents a saturated or unsaturated ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₂, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

3) an A-X—

B—

Y—

C group,

wherein

A represents a saturated or unsaturated ring system comprising 1 to 3 optionally condensed rings, in which additionally at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

X represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

B represents a saturated or unsaturated ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹ group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

Y represents a bond, a —

NH—

group, a —

(C═

O)—

group, a branched or linear, optionally substituted C_1-6-aliphatic chain, —

O—

, or a —

SO₂—

group;

C represents a saturated or unsaturated ring system comprising 1 to 2 optionally condensed rings, in which at least 1 carbon atom is optionally replaced by N, S or O and which is optionally at least mono-substituted by F, Cl, Br, I, NH₂, SH, OH, oxo, CF₃, a C_1-6-aliphatic group;

a C_1-6-alkyl-aryl group;

a C_1-6-alkyl-heteroaryl group;

a C_1-6-alkoxy group;

a (C═

O)—

R⁹ group;

a (C═

O)—

OR¹⁰ group;

a CH2-(C═

O)—

O—

R¹¹ group;

a (SO₂)—

R¹¹group;

a NH—

R¹¹ group;

or a (C═

O)—

NR¹²R^12a group;

R⁵ and R⁶ represent a hydrogen atom, an unbranched or branched, saturated or unsaturated, optionally at least mono-substituted aliphatic radical;

a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing cycloalkyl group, which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing alkyl-cycloalkyl group;

an optionally at least mono-substituted aryl group which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

an optionally at least mono-substituted heteroaryl group which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-aryl group in which the aryl group may be condensed with a mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-heteroaryl group in which the heteroaryl group may be condensed with a mono- or polycyclic ring system;

R⁷ and R^7a, identical or different, represent a hydrogen atom, an unbranched or branched, saturated or unsaturated, optionally at least mono-substituted aliphatic radical;

a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing cycloalkyl group, which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing alkyl-cycloalkyl group;

an optionally at least mono-substituted aryl group which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

an optionally at least mono-substituted heteroaryl group which may be condensed with an optionally at least mono-substituted mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-aryl group in which the aryl group may be condensed with a mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-heteroaryl group in which the heteroaryl group may be condensed with a mono- or polycyclic ring system;

R⁸ represents a hydrogen atom;

a branched or unbranched, saturated or unsaturated, unsubstituted aliphatic group;

R⁹, R¹⁰ and R¹¹ represent a hydrogen atom, an unbranched or branched, saturated or unsaturated, optionally at least mono-substituted aliphatic radical;

a branched or unbranched, saturated or unsaturated, optionally at least mono- substituted, optionally at least one heteroatom as ring member containing alkyl-cycloalkyl group;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-aryl group in which the aryl group may be condensed with a mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-heteroaryl group in which the heteroaryl group may be condensed with a mono- or polycyclic ring system;

R¹² and R^12a, identical or different, represent a hydrogen atom, an unbranched or branched, saturated or unsaturated, optionally at least mono-substituted aliphatic radical;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as ring member containing alkyl-cycloalkyl group;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-aryl group in which the aryl group may be condensed with a mono- or polycyclic ring system;

a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted alkyl-heteroaryl group in which the heteroaryl group may be condensed with a mono- or polycyclic ring system;

with the provisos that

if R² represents a hydrogen atom;

and R¹ represents a hydrogen atom or a condensed aryl group;

R³ and R⁴ may not form together with their bridging nitrogen atom a triazole group;

if R² represents a hydrogen atom;

and R¹ represents a hydrogen atom;

a substituted C_1-2 alkyl group;

a condensed aryl group;

a benzyl group;

R³ and R⁴ may not form together with their bridging nitrogen atom a substituted, unsaturated, condensed ring system containing at least 4 nitrogen atoms as ring members;

an unsaturated, (C═

O)-substituted, uncondensed, 6-membered ring system in which two carbon atoms are replaced by nitrogen.

if R² represents a hydrogen atom;

and R³ and R⁴ form together with their bridging nitrogen atom a pyrrolidine ring, a piperidine ring, a piperazine ring or a morpholine ring;

R¹ may not represent a hydrogen atom;

a methyl group;

an unsaturated tert-butyl group;

a (C═

O)-substituted alkyl-heteroaryl group;

if R² represents a hydrogen atom;

and R¹ does not represent a benzyl group;

and either R³ or R⁴ represents a hydrogen atom;

either R³ or R⁴ may not represent a substituted alkyl-heteroaryl group;

an alkyl-aryl group;

a substituted heteroaryl group;

an unsubstituted methyl group;

a substituted alkyl group;

an aryl group;

a cyclohexyl group;

an alkyl-cycloalkyl group wherein the cycloalkyl group contain at least one heteroatom;

if R² represents a hydrogen atom;

and R¹ represents an alkyl group;

and either R³ or R⁴ represents a hydrogen atom;

either R³ or R⁴ may not represent a substituted or unsubstituted C_1-2 alkyl group;

a branched C₁-₁ alkyl group;

a substituted or unsubstituted C_3-6 cycloalkyl group in which optionally at least one carbon atom is optionally replaced by N, S or O;

a cycloheptyl group;

if R² represents a hydrogen atom;

and R¹ represents an alkyl group;

either R³ or R⁴ may not represent a cyclohexyl group while the other represents at the same time an alkyl-aryl group;

or either R³ or R⁴ may not represent an alkyl group while the other represents at the same time an alkyl-aryl group;

if R² represents a hydrogen atom;

and R¹ represents a benzhydryl group;

and either R³ or R⁴ represents a hydrogen atom;

either R³ or R⁴ may not represent a (C═

O)-substituted alkyl-aryl group;

a (C═

O)-substituted aryl group;

if R² represents a hydrogen atom;

and R¹ represents benzyl;

and either R³ or R⁴ represents a hydrogen atom;

either R³ or R⁴ may not represent a substituted or unsubstituted C_1-2 alkyl group;

a substituted C_3-8 alkyl group;

a substituted aryl group;

a substituted alkyl-aryl group;

or

R³ or R⁴, together with their bridging nitrogen atom may not form a tetrahydropyrimidine ring;

a triazolo pyrimidine ring;

if R² represents a benzyl group;

and either R³ or R⁴ represents a hydrogen atom;

either R³ or R⁴ may not represent a (C═

O)-substituted alkyl-aryl group;

if R² represents a C_1-3 alkyl group;

and either R³ or R⁴ represents a hydrogen atom either R³ or R⁴ may not represent an unsubstituted C_1-2 alkyl group;

a substituted alkyl group;

a substituted or unsubstituted aryl group;

a substituted heteroaryl group;

a (C═

O)-substituted alkyl-aryl group;

optionally in form of one of the stereoisomers, preferably enantiomers or diastereomers, a racemate or in form of a mixture of at least two of the stereoisomers, preferably enantiomers and/or diastereomers, in any mixing ratio, or a corresponding salt thereof, or a corresponding solvate thereof, or a prodrug thereof,

and one or more pharmaceutically acceptable excipients and/or carriers.

58. A method for the prophylaxis and/or treatment of a sigma receptor-mediated disease or condition, which comprises administering to a subject in need thereof at least one substituted pyrrolidine compound according to claim 1.

34-57. -57. (canceled)

59-63. -63. (canceled)