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Amino-5-(5-membered)heteroarylimidazolone Compounds And The Use Thereof For Beta-secretase Modulation

  • US 20100168106A1
  • Filed: 03/08/2010
  • Published: 07/01/2010
  • Est. Priority Date: 06/30/2005
  • Status: Abandoned Application
First Claim
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1. A compound of formula I wherein W is CO, CS or CH2;

  • X is N, NR, NO, S, SOm, O or CR9;

    Y is N, NR, NO, S, SOm, O or CR10;

    Z is C, N, NR, NO, S, SOm, O, CR11 or CR11R12 with the proviso that at least one of X, Y or Z must be N, NR, NO, S, SOm or O;

    m is 1 or 2;

    R is H or a C1-C6alkyl, C1-C6haloalkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C8cycloalkyl or aryl(C1-C6)alkyl group each optionally substituted;

    R1 and R2 are each independently H, COR14, CO2R15 or an optionally substituted C1-C4alkyl group;

    R3 is H, OR13 or a C1-C6alkyl, C1-C6haloalkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C8cycloalkyl or aryl(C1-C6)alkyl group each optionally substituted;

    R4 R5, R9 and R10 are each independently H, halogen, NO2, CN, OR14, CO2R15, COR16, NR17R18, SOpNR19R20 or a C1-C6alkyl, C1-C6haloalkyl, C2-C6alkenyl, C2-C6alkynyl or C3-C8cycloalkyl group each optionally substituted;

    R6 and R8 are each independently H, halogen, NO2, CN, OR21, NR22R23 or a C1-C6alkyl, C1-C6haloalkyl, C2-C6alkenyl, C2-C6alkynyl or C3-C8cycloalkyl group each optionally substituted;

    R7 is H, halogen, NO2, CN, OR24, NR25R26 or a C1-C6alkyl, C1-C6haloalkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C8cycloalkyl, aryl or heteroaryl group each optionally substituted;

    R11, R12, R13, R14, R15, R16, R21, R24, R27, R28 and R29 are each independently H or a C1-C6alkyl, C1-C6haloalkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C8cycloalkyl, cycloheteroalkyl or aryl group each optionally substituted;

    R17, R18, R19, R20, R22, R23, R25, R26, R30, R31, R32 and R33 are each independently H, COR34, SOpR35 or a C1-C4alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C8 cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group each optionally substituted or R17, R18, or R19, R20 or R22, R23, or R25, R26, or R30, R31, or R32, R33 may be taken together with the atom to which they are attached to form an optionally substituted 5- to 7-membered ring optionally containing an additional heteroatom selected from O, N or S;

    R34 is H, or a C1-C6alkyl, C1-C6haloalkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C8cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group each optionally substituted; and

    R35 is a C1-C6alkyl, C1-C6haloalkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C8cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group each optionally substituted;

    ora tautomer thereof, a stereoisomer thereof or a pharmaceutically acceptable salt thereof.

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