METHODS AND APPARATUSES RELATED TO BLOOD ANALYTE MEASUREMENT SYSTEM
First Claim
1. An apparatus for measuring an analyte in blood taken from a patient, comprising:
- a. A patient interface device, capable of interfacing with the circulatory system of a patient;
b. An analyte sensor having first and second ports, with the first port in fluid communication with the patient interface device;
c. A flow generation and reservoir system having first and second ports, with the first port in fluid communication with second port of the analyte sensor; and
d. A first fluid source, mounted such that it can be placed in fluid communication with the second port of the flow generation and storage system, wherein the first fluid source provides a first fluid having a first predetermined analyte concentration.
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Abstract
The present invention relates to a blood analyte measurement system for the procurement of blood samples for measurement of blood properties such as analyte concentration or analyte presence. A blood access system can be coupled with a measurement system such as an electrochemical sensor, and can also be used with other measurement modalities. Embodiments of the present invention can facilitate accurate measurement of blood glucose by the clinician in a sterile manner. Embodiments of the present invention can also enable the calibration of the sensor at one or more calibration points. One desired analyte of measurement is glucose for the effective implementation of glycemic control protocols. Embodiments of the present invention can also be used for the measurement of other analytes such as arterial blood gases, lactate, hemoglobin, potassium and urea. Additionally, embodiments of the present invention can function effectively on a variety of blood access points and specifically enables glucose monitoring in an existing arterial line that is already in place for hemodynamic monitoring. The present invention does not consume a significant amount of blood. Some embodiments of the present invention can re-infuse the blood into the patient, which can facilitate operation of the system in a sterile manner.
194 Citations
49 Claims
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1. An apparatus for measuring an analyte in blood taken from a patient, comprising:
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a. A patient interface device, capable of interfacing with the circulatory system of a patient; b. An analyte sensor having first and second ports, with the first port in fluid communication with the patient interface device; c. A flow generation and reservoir system having first and second ports, with the first port in fluid communication with second port of the analyte sensor; and d. A first fluid source, mounted such that it can be placed in fluid communication with the second port of the flow generation and storage system, wherein the first fluid source provides a first fluid having a first predetermined analyte concentration. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 45, 46, 47, 48, 49)
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36. An apparatus for measuring an analyte in blood taken from a patient, comprising:
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a. A patient interface device, capable of interfacing with the circulatory system of a patient; b. An analyte sensor having first and second ports, with the first port in fluid communication with the patient interface device; c. A flow generation and reservoir system having first and second ports, with the first port in fluid communication with second port of the analyte sensor; d. A first fluid source, mounted such that it can be placed in fluid communication with the second port of the flow generation and reservoir system, wherein the first fluid source provides a first fluid having a first predetermined analyte concentration; and e. A second fluid source, mounted such that it can be placed in fluid communication with the second port of the analyte sensor, wherein the second fluid source provides a second fluid having a second predetermined analyte concentration, where the second predetermined analyte concentration is different than the first predetermined analyte concentration.
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37. An apparatus for the measurement of an analyte, comprising:
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a. A patient interface device capable of interfacing with the circulatory system of a patient; b. An analyte sensor having first and second ports, with the first port in fluid communication with the patient interface device; c. A flow generation device having first and second ports, with the first port in fluid communication with second port of the analyte sensor; d. A waste channel in fluid communication with the second port of the flow generation device through a first flow control device that allows fluid flow from the flow generation device to the waste channel but substantially prevents fluid from the waste channel to the flow generation device; e. A first fluid source, mounted such that it can be placed in fluid communication with the second port of the flow generation device through a second flow control device that allows fluid flow from the first fluid source to the flow generation device but substantially prevents fluid from the flow generation device to the first fluid source, wherein the first fluid source provides a first fluid having a first predetermined analyte concentration. - View Dependent Claims (38, 39, 40, 41, 42, 43, 44)
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Specification