DETERMINING CATHETER STATUS
First Claim
1. A method for determining status of an implanted catheter, the catheter having a delivery region intended to be positioned in a target location of a patient, the delivery region being in communication with a lumen of the catheter, the method comprising:
- measuring pressure within the lumen of the catheter;
developing a physiological pressure modulation profile based on the measured pressure;
infusing or withdrawing a bolus of fluid into or from the lumen of the catheter;
measuring pressure within the lumen of the catheter created by the bolus;
developing a bolus pressure modulation profile based on the measured bolus pressure; and
determining the status of the catheter by comparing the developed bolus pressure modulation profile to a predetermined bolus pressure profile and by comparing the developed physiological pressure modulation profile to a predetermined physiological pressure profile of the target location.
1 Assignment
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Accused Products
Abstract
A method for monitoring the status of an implanted catheter includes monitoring changes in pressure within a lumen of a catheter associated with physiological parameters (“physiological pressure”) and changes in pressure within the lumen of the catheter associated with bolus infusion of fluid into the catheter or bolus withdrawal of infusion from the catheter (“bolus pressure”). Methods that employ monitoring both physiological pressure and bolus pressure can provide information that cannot be obtained from monitoring physiological pressure or bolus pressure alone.
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Citations
20 Claims
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1. A method for determining status of an implanted catheter, the catheter having a delivery region intended to be positioned in a target location of a patient, the delivery region being in communication with a lumen of the catheter, the method comprising:
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measuring pressure within the lumen of the catheter; developing a physiological pressure modulation profile based on the measured pressure; infusing or withdrawing a bolus of fluid into or from the lumen of the catheter; measuring pressure within the lumen of the catheter created by the bolus; developing a bolus pressure modulation profile based on the measured bolus pressure; and determining the status of the catheter by comparing the developed bolus pressure modulation profile to a predetermined bolus pressure profile and by comparing the developed physiological pressure modulation profile to a predetermined physiological pressure profile of the target location. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method for determining whether a delivery region of an implanted catheter has migrated out of a cerebrospinal fluid compartment, comprising:
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measuring pressure within a lumen of the catheter; developing a physiological pressure modulation profile based on the measured pressure; determining whether the developed physiological pressure modulation profile is indicative of a catheter having a delivery region in the cerebrospinal fluid compartment by comparing the developed physiological pressure modulation profile to a predetermined physiological pressure profile of the cerebrospinal fluid compartment; infusing or withdrawing a bolus of fluid into or from a lumen of the catheter, wherein the lumen is in communication with the delivery region; measuring pressure within the lumen of the catheter created by the bolus; developing a bolus pressure modulation profile based on the measured bolus pressure; determining whether the developed bolus pressure modulation profile is indicative of a catheter complication by comparing the developed bolus pressure modulation profile to a predetermined bolus pressure profile; and determining that the delivery region of the catheter has migrated out of the cerebrospinal fluid compartment if (i) the developed physiological pressure modulation profile is determined not to be indicative of a catheter having a delivery region in the cerebrospinal fluid compartment, and (ii) the developed bolus pressure modulation profile is determined to not be indicative of a catheter complication. - View Dependent Claims (14, 15)
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16. A method for determining whether a catheter having a delivery region implanted in a cerebrospinal fluid compartment has a leak within the cerebrospinal fluid compartment, comprising:
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measuring pressure within a lumen of the catheter; developing a physiological pressure modulation profile based on the measured pressure; determining whether the developed physiological pressure modulation profile is indicative of a catheter having a delivery region in the cerebrospinal fluid compartment by comparing the developed physiological pressure modulation profile to a predetermined physiological pressure profile of the cerebrospinal fluid compartment; infusing or withdrawing a bolus of fluid into or from a lumen of the catheter, wherein the lumen is in communication with the delivery region; measuring pressure within the lumen of the catheter created by the bolus; developing a bolus pressure modulation profile based on the measured bolus pressure; determining whether the developed bolus pressure modulation profile is indicative of a catheter having a leak by comparing the developed bolus pressure modulation profile to a predetermined bolus pressure profile; and determining that the catheter has a leak within the cerebrospinal fluid compartment if (i) the developed physiological pressure modulation profile is determined to be indicative of a catheter having a delivery region in the cerebrospinal fluid compartment, and (ii) the developed bolus pressure modulation profile is determined to be indicative of a catheter having a leak. - View Dependent Claims (17, 18)
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19. A method for determining whether a catheter having a delivery region implanted in a cerebrospinal fluid compartment is adjacent a solid tissue, comprising:
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measuring pressure within a lumen of the catheter; developing a physiological pressure modulation profile based on the measured pressure; determining whether the developed physiological pressure modulation profile is indicative of a catheter having a delivery region in the cerebrospinal fluid compartment by comparing the developed physiological pressure modulation profile to a predetermined physiological pressure profile of the cerebrospinal fluid compartment; withdrawing a bolus of fluid from a lumen of the catheter, wherein the lumen is in communication with the delivery region; measuring pressure within the lumen of the catheter created by the bolus; developing a first bolus pressure modulation profile based on the measured bolus pressure; determining whether the developed first bolus pressure modulation profile is indicative of a catheter having an occlusion by comparing the developed first bolus pressure modulation profile to a predetermined bolus pressure profile; infusing a bolus of fluid into the lumen of the catheter; measuring pressure within the lumen of the catheter created by the bolus; developing a second bolus pressure modulation profile based on the measured bolus pressure; determining whether the developed second bolus pressure modulation profile is indicative of a catheter having an occlusion by comparing the developed second bolus pressure modulation profile to a predetermined bolus pressure profile; and determining that the delivery region is adjacent a solid tissue if (i) the developed physiological pressure modulation profile is determined to be indicative of a catheter having a delivery region in the cerebrospinal fluid compartment, (ii) the developed first bolus pressure modulation profile is determined to be indicative of an occlusion, and (iii) the developed second bolus pressure modulation profile is not determined to be indicative of an occlusion.
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20. A method for determining status of an implanted catheter, the catheter having a delivery region intended to be positioned in a target location of a patient, the delivery region being in communication with a lumen of the catheter, the method comprising:
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measuring pressure within the lumen of the catheter; developing a physiological pressure modulation profile based on the measured pressure; determining whether the developed physiological pressure modulation profile is indicative of a catheter complication by comparing the developed physiological pressure modulation profile to a predetermined physiological pressure profile of the target location; and if the developed physiological pressure modulation profile is determined to be indicative of a catheter complication, then (i) infusing or withdrawing a bolus of fluid into or from the lumen of the catheter; (ii) measuring pressure within the lumen of the catheter created by the bolus; (iii) developing a bolus pressure modulation profile based on the measured bolus pressure; and (iv) determining whether the developed bolus pressure modulation profile is indicative of a catheter complication by comparing the developed bolus pressure modulation profile to a predetermined bolus pressure profile.
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Specification