Tissue integration implant

• US 20100168869A1
• Filed: 12/31/2008
• Published: 07/01/2010
• Est. Priority Date: 12/31/2008
• Status: Abandoned Application

• Current Assignee: Howmedica Osteonics Corp. (Stryker Corporation)
• Original Assignee: Howmedica Osteonics Corp. (Stryker Corporation)
• Inventors: Long, Marc, Davisson, Twana
• Application Number:
  US12/319,138
• Publication Number:
  US 20100168869A1
• Time in Patent Office: Days
• US Class Current: 623/23.720
• CPC Class Codes: A61F 2/08 Muscles; Tendons; Ligaments sutures A61B17/04
• CPC Class Codes: A61F 2/0811 Fixation devices for tendons or ligaments
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2/30756 Cartilage endoprostheses A61F2/3603 takes precedence
• CPC Class Codes: A61F 2/3872 Meniscus for implantation between the natural bone surfaces
• CPC Class Codes: A61F 2002/087 Anchor integrated into tendons, e.g. bone blocks, integrated rings
• CPC Class Codes: A61F 2002/30059 differing in bone mineralization, e.g. made from both mineralized and demineralized adjacent parts
• CPC Class Codes: A61F 2002/30062 (bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
• CPC Class Codes: A61F 2002/30074 stretchable
• CPC Class Codes: A61F 2002/30075 swellable, e.g. when wetted
• CPC Class Codes: A61F 2002/30224 cylindrical
• CPC Class Codes: A61F 2002/30293 Cylindrical body made by spirally rolling up a sheet or a strip around itself
• CPC Class Codes: A61F 2002/30759 Mosaicplasty, i.e. using a plurality of individual cartilage plugs for filling a substantial cartilage defect
• CPC Class Codes: A61F 2002/30762 Means for culturing cartilage
• CPC Class Codes: A61F 2002/30766 Scaffolds for cartilage ingrowth and regeneration
• CPC Class Codes: A61F 2002/3092 having an open-celled or open-pored structure
• CPC Class Codes: A61F 2002/4495 having a fabric structure, e.g. made from wires or fibres
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61F 2210/0057 stretchable
• CPC Class Codes: A61F 2210/0061 swellable
• CPC Class Codes: A61F 2230/0069 : cylindrical
• CPC Class Codes: A61F 2230/0091 : helically-coiled or spirally-coiled, i.e. having a 2-D spiral cross-section
• CPC Class Codes: A61F 2310/00359 : Bone or bony tissue
• CPC Class Codes: A61F 2310/00365 : Proteins; Polypeptides; Degradation products thereof

Abstract

The present invention relates to a tissue defect repair implant including a porous material, wherein the material is expandable or compressible. The implant may be a scaffold, and may also be formed of a material such as, for example, collagen or demineralized bone matrix. Another aspect of the invention may be a method for the repair of a tissue defect in a patient in need thereof, including implanting an implant between two adjacent tissues, wherein the implant may include a porous material which is expandable or compressible. The two tissues may be soft tissue and hard tissue, and alternatively, the two tissues may be soft tissue, and may further be the same or different soft tissues.

Claims

1. An implant for repairing a tissue defect, comprising a porous material, wherein said material is expandable or compressible.

2. The implant of claim 1, wherein said porous material allows tissue ingrowth.

3. The implant of claim 1, wherein said material comprises a scaffold.

4. The implant of claim 1, wherein said material comprises collagen or demineralized bone matrix.

5. The implant of claim 1, wherein said material comprises a material selected from the group consisting of autologous tissue, allogenic tissue, xenogenic tissue, and synthetic material.

6. The implant of claim 1, wherein said material is expandable by at least 5% by volume.

7. The implant of claim 1, wherein said material is compressible by at least 5% by volume.

8. A method for the repair of a tissue defect in a patient in need thereof, comprising implanting at least one implant between two adjacent tissues, wherein said implant comprises a porous material, wherein said implant is expandable or compressible.

9. The method of claim 8, wherein said two tissues comprise bone and a soft tissue selected from the group consisting of tendons, ligaments, fibrous tissues, meniscus tissue, muscle, cartilage, skin, dermal layers, joint capsule, and synovium.

10. The method of claim 9, further comprising reattaching said soft tissue to said bone, wherein said adjacent two tissues comprise a defect, wherein said defect is a connection site between bone and soft tissue selected from the group consisting of tendons, ligaments, fibrous tissues, meniscus tissue, muscle, cartilage, skin, dermal layers, joint capsule, and synovium.

11. The method of claim 8, wherein said two tissues comprise soft tissue selected from the group consisting of tendons, ligaments, fibrous tissues, meniscus tissue, muscle, cartilage, skin, dermal layers, joint capsule, and synovium.

12. The method of claim 8, wherein said implant is placed within said defect such that the adjacent tissues integrate through the implant.

13. The method of claim 8, wherein said material comprises a scaffold.

14. The method of claim 8, wherein said material comprises a material selected from the group consisting of collagen and demineralized bone matrix.

15. The method of claim 8, wherein said material comprises a material selected from the group consisting of autologous tissue, allogenic tissue, xenogenic tissue, and synthetic material.

16. The method of claim 8, wherein said implant is placed in between the two tissues such that at least one of the two tissues integrate through said implant.

17. The implant of claim 8, wherein the step of implanting an implant further comprises implanting multiple implants between two adjacent tissues.

18. The implant of claim 9, wherein said implant further comprises cells selected from the group consisting of embryonic stem cells, stem cells, bone marrow cells, mesenchymal cells, synovium cells, synovial fluid cells, progenitor cells, chondroblasts, chondrocytes, and osteoblasts.