Small Volume In Vitro Analyte Sensor and Methods of Making
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Abstract
A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry; and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
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Citations
15 Claims
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1-11. -11. (canceled)
- 12. A biosensor which, having a reagent layer including a reagent which reacts specifically with a specific component in a sample solution, measures the concentration of the specific component in the sample solution, said reagent layer including glucose dehydrogenase having flavin adenine dinucleotide as a coenzyme.
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