ANTIMICROBIAL COMPOSITIONS CONTAINING LOW CONCENTRATIONS OF BOTANICALS

• US 20100172847A1
• Filed: 01/26/2010
• Published: 07/08/2010
• Est. Priority Date: 06/20/2007
• Status: Active Grant

• Current Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Original Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Inventors: Caraos, Lauserpina, Modak, Shanta, Baiju, Nayana
• Granted Patent: US 9,687,429 B2
• Time in Patent Office: Days
• US Class Current: 424/58
• CPC Class Codes: A61K 31/19 Carboxylic acids, e.g. valproic acid salicylic acid A61K31/60
• CPC Class Codes: A61K 8/365 Hydroxycarboxylic acids; Ketocarboxylic acids
• CPC Class Codes: A61K 8/922 of vegetable origin
• CPC Class Codes: A61Q 11/02 Preparations for deodorising, bleaching or disinfecting dentures
• CPC Class Codes: A61Q 15/00 Anti-perspirants or body deodorants deodorisation of air A61L9/00
• CPC Class Codes: A61Q 17/005 Antimicrobial preparations
• CPC Class Codes: A61Q 19/10 Washing or bathing preparations
• CPC Class Codes: A61Q 5/02 Preparations for cleaning the hair

Abstract

The present invention relates to a preservative or antimicrobial compositions with broad spectrum antimicrobial activity comprising low concentrations of essential oil (and/or one or more component thereof) and a botanical extract in synergistic combination with a fruit acid and alkanediol, and optionally a solvent. The compositions of the invention may be used in personal care products such as creams or soap products.

Claims

1. A preservative composition comprising:

(a) one or more essential oil or individual constituent thereof, wherein each essential oil or individual constituent is present at a concentration between about 0.3 and 15% (weight/weight);

(b) a botanical extract at a concentration between about 0.3 and 30% (weight/weight);

(c) a fruit acid at a concentration between about 5 and 20% (weight/weight); and

(d) an alkanediol at a concentration between about 1 and 80% (weight/weight).

2. The preservative composition of claim 1, wherein the concentration of the essential oil or individual constituent thereof is between about 0.5 and 6.0% (weight/weight).

3. The preservative composition of claim 1, wherein the total concentration of the essential oils and botanical extracts in concentrations is between about 0.5 and about 30% (weight/weight).

4. The preservative composition of claim 3, wherein the total concentration of essential oils and botanical extracts in concentrations is between about 2 and about 20% (weight/weight).

5. The preservative composition of claim 1, wherein the concentration of fruit acids is between about 10 and 20% (weight/weight).

6. The preservative composition of claim 1, wherein the concentration of alkanediols is between about 30 and 80% (weight/weight).

7. The preservative composition of claim 6, wherein the concentration of alkanediols is between about 20 and 50% (weight/weight).

8. The preservative composition of claim 1, further comprising a solvent.

9. The preservative composition of claim 8, wherein the concentration of solvent is between about 0 and 90% (weight/weight).

10. The preservative composition of claim 1, wherein the essential oil and/or constituent thereof is selected from the group consisting of lemongrass oil, an individual constituent of lemongrass oil, orange oil, an individual constituent of orange oil, cinnamon leaf oil, and individual constituent of cinnamon leaf oil, basil oil, and an individual constituent of basil oil, safflower oil, and individual constituent of safflower oil, manuka oil, and an individual constituent of manuka oil, and pomegranate oil, and an individual constituent of pomegranate oil.

11. The preservative composition of claim 1, wherein the fruit acid is selected from the group consisting of lactic acid, citric acid, and multifruit BSC.

12. The preservative composition of claim 1, wherein the botanical extract is selected from the group consisting of grape seed extract, grapefruit seed extract, and pomegranate extract.

13. The preservative composition of claim 1, wherein the alkanediol is octanediol.

14. The preservative composition of claim 8, wherein the solvent is selected from the group consisting of phenoxyethanol, propylene glycol, and glycerine.

15. The preservative composition of claim 1, wherein the composition is suitable for use as a personal care product selected from the group consisting of a bar soap, a liquid hand soap, a hand sanitizer, wound care product, a body wash, an acne treatment, a shampoo, a hair conditioner, a cosmetic, a deodorant, a body lotion, a hand cream, a topical cream, an aftershave lotion, a skin toner, a mouth wash, a toothpaste, a sunscreen lotion, a baby cleansing wipe, a disinfecting wipe, and a diaper cream.

16. The preservative composition of claim 15, wherein the composition is used in concentrations from about 1 to 5% (weight/weight) in personal care products.

17. The preservative composition of claim 1, wherein regular exposure of skin to the composition does not produce skin irritation in a normal subject.

18. An antimicrobial composition comprising:

(a) one or more essential oil or individual constituent thereof, wherein each essential oil or individual constituent is present at a concentration between about 0.5 and 15% (weight/weight);

(b) a botanical extract at a concentration between about 1 and 30% (weight/weight);

(c) a fruit acid at a concentration between about 5 and 20% (weight/weight);

(d) an alkanediol at a concentration between about 1 and 20% (weight/weight); and

(e) a solvent at a concentration between about 0 and 90% (weight/weight).

19. The antimicrobial composition of claim 18, wherein the composition is suitable for use as a personal care product selected from the group consisting of a bar soap, a liquid hand soap, a hand sanitizer, wound care product, a body wash, an acne treatment, a shampoo, a hair conditioner, a cosmetic, a deodorant, a body lotion, a hand cream, a topical cream, an aftershave lotion, a skin toner, a mouth wash, a toothpaste, a sunscreen lotion, a baby cleansing wipe, a disinfecting wipe, and a diaper cream.

20. The antimicrobial composition of claim 19, wherein the composition is used in concentrations from about 10 to about 20% (weight/weight) in personal care products.

21. The antimicrobial composition of claim 18, wherein the solvent is selected from the group consisting of alcohol, phenoxyethanol, propylene glycol, and glycerine.