SKIN AND SURFACE DISINFECTANT COMPOSITIONS CONTAINING BOTANICALS

• US 20100172848A1
• Filed: 01/26/2010
• Published: 07/08/2010
• Est. Priority Date: 08/01/2008
• Status: Abandoned Application

• Current Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Original Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Inventors: Modak, Shanta, Caraos, Lauserpina, Baiju, Nayana
• Application Number:
  US12/694,141
• Publication Number:
  US 20100172848A1
• Time in Patent Office: Days
• US Class Current: 424/58
• CPC Class Codes: A01N 25/02 containing liquids as carriers, diluents or solvents
• CPC Class Codes: A01N 37/36 containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
• CPC Class Codes: A01N 65/00 Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof containing compounds of determined constitution A01N27/00 - A01N59/00
• CPC Class Codes: A01N 65/06 Coniferophyta [gymnosperms], e.g. cypress
• CPC Class Codes: A01N 65/12 Asteraceae or Compositae [Aster or Sunflower family], e.g. daisy, pyrethrum, artichoke, lettuce, sunflower, wormwood or tarragon
• CPC Class Codes: A01N 65/22 Lamiaceae or Labiatae [Mint family], e.g. thyme, rosemary, skullcap, selfheal, lavender, perilla, pennyroyal, peppermint or spearmint
• CPC Class Codes: A01N 65/24 Lauraceae [Laurel family], e.g. laurel, avocado, sassafras, cinnamon or camphor
• CPC Class Codes: A01N 65/36 Rutaceae [Rue family], e.g. lime, orange, lemon, corktree or pricklyash
• CPC Class Codes: A01N 65/44 Poaceae or Gramineae [Grass family], e.g. bamboo, lemon grass or citronella grass
• CPC Class Codes: A61K 8/922 of vegetable origin
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
• CPC Class Codes: A61Q 15/00 Anti-perspirants or body deodorants deodorisation of air A61L9/00
• CPC Class Codes: A61Q 17/005 Antimicrobial preparations
• CPC Class Codes: A61Q 17/04 Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/002 Aftershave preparations
• CPC Class Codes: A61Q 19/005 Preparations for sensitive skin
• CPC Class Codes: A61Q 19/10 Washing or bathing preparations
• CPC Class Codes: A61Q 5/12 Preparations containing hair conditioners
• CPC Class Codes: C11D 3/18 Hydrocarbons C11D3/164 takes precedence
• CPC Class Codes: C11D 3/2003 : Alcohols; Phenols
• CPC Class Codes: C11D 3/201 : linear
• CPC Class Codes: C11D 3/2017 : branched
• CPC Class Codes: C11D 3/2034 : aromatic
• CPC Class Codes: C11D 3/2041 : Dihydric alcohols
• CPC Class Codes: C11D 3/2044 : linear
• CPC Class Codes: C11D 3/2075 : Carboxylic acids-salts thereof
• CPC Class Codes: C11D 3/2079 : Monocarboxylic acids-salts thereof
• CPC Class Codes: C11D 3/2086 : Hydroxy carboxylic acids-salts thereof
• CPC Class Codes: C11D 3/382 : Vegetable products, e.g. soya meal, wood flour, sawdust
• CPC Class Codes: C11D 3/48 : Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions

Abstract

The present invention relates to a skin or surface disinfectant composition with broad spectrum antimicrobial activity comprising one or more essential oil (and/or one or more component thereof) and one or more fruit acid. The compositions of the invention may be used as non-toxic alternatives to conventional disinfectants or may be added to other antimicrobial agents to enhance their activity. The invention provides effective alternatives to harsher products which may be particularly useful in personal care and household products and where children and/or pet exposure may be a concern.

Claims

1. A personal care product composition comprising (i) one or more essential oil or individual constituent thereof at a concentration between about 0.1 and 1.2 percent (weight/weight);

and (ii) a fruit acid at a concentration between about 0.5 and 1.5 percent (weight/weight);

having one or more characteristic selected from the group consisting of;

(a) the composition further comprises one or more than one component selected from the group consisting of emollients, thickening agents, gelling agents, humectants, silicone polymers, and hydrogels;

(b) the composition is suitable for use as a personal care product selected from the group consisting of a bar soap, a liquid hand soap, a hand sanitizer, wound care product, a body wash, an acne treatment, a shampoo, a hair conditioner, a cosmetic, a deodorant, a body lotion, a hand cream, a topical cream, an aftershave lotion, a skin toner, a mouth wash, a toothpaste, a sunscreen lotion, a baby cleansing wipe, and a diaper cream; and

(c) regular exposure of the skin to the composition does not produce skin irritation in a normal subject.

2. The personal care product composition of claim 1, wherein (i) the one or more essential oil or individual constituent thereof is present at a concentration between about 0.1 and 1 percent (weight/weight);

(ii) the fruit acid is present at a concentration between about 0.125 and 1 percent (weight/weight); and

further comprising alcohol at a concentration between about 5 and 20 percent (weight/weight).

3. The personal care product composition of claim 2, further comprising triclosan at a concentration between about 0.05 and 1 percent (weight/weight).

4. The personal care product composition of claim 1, 2 or 3, wherein the essential oil and/or constituent thereof is selected from the group consisting of lemongrass oil, an individual constituent of lemongrass oil, orange oil, an individual constituent of orange oil, cinnamon leaf oil, and individual constituent of cinnamon leaf oil, basil oil, and an individual constituent of basil oil.

5. The personal care product composition of claim 1, 2 or 3, wherein the fruit acid is citric acid.

6. The personal care product composition of claim 4, wherein the fruit acid is citric acid.

7. The personal care product composition of claim 1, further comprising an anti-inflammatory agent.

8. The personal care production composition of claim 7, wherein the anti-inflammatory agent is calendula oil at a concentration between about 0.3 and 0.7 percent (weight/weight).

9. A personal care product composition comprising:

(i) lemongrass oil or an individual constituent thereof;

(ii) orange oil or an individual constituent thereof;

(iii) fruit acid at a concentration between about 0.25 and 1 percent (weight/weight); and

(iv) alcohol at a concentration between about 5 and 20 percent (weight/weight),

wherein the total concentration of lemon grass oil or an individual constituent thereof and orange oil or an individual constituent thereof is between about 0.2 and 0.7 percent (weight/weight).

10. The personal care product composition of claim 9, further comprising triclosan at a concentration between about 0.05 and 1 percent.

11. The personal care product composition of claim 9 or 10, wherein the fruit acid is citric acid.

12. The personal care product composition of claim 9 or 10, which is suitable for use as a personal care product selected from the group consisting of a bar soap, a liquid hand soap, a hand sanitizer, a body wash, an acne treatment, a shampoo, a hair conditioner, a cosmetic, a deodorant, a body lotion, a hand cream, a topical cream, an aftershave lotion, a skin toner, a mouth wash, a toothpaste, a sunscreen lotion, a baby cleansing wipe, and a diaper cream.

13. The personal care product composition of claim 11, which is suitable for use as a personal care product selected from the group consisting of a bar soap, a liquid hand soap, a hand sanitizer, a body wash, an acne treatment, a shampoo, a hair conditioner, a cosmetic, a deodorant, a body lotion, a hand cream, a topical cream, an aftershave lotion, a skin toner, a mouth wash, a toothpaste, a sunscreen lotion, a baby cleansing wipe, and a diaper cream.

14. A surface cleaner composition comprising more than one essential oil or constituent thereof at a total concentration between about 0.1 and 1 percent (weight/weight), a fruit acid at a concentration of between about 1 and 2 percent (weight/weight), and an alcohol, at a concentration of between about 5 and 20 percent (weight/weight), where the essential oils or constituents thereof are selected from the group consisting of lemongrass oil, an individual constituent of lemongrass oil, orange oil, and individual constituent of orange oil, basil oil, an individual constituent of basil oil, pine oil, and an individual constituent of pine oil.

15. The surface cleaner composition of claim 14, further comprising a surfactant.

16. The surface cleaner composition of claim 14, comprising pine oil and orange oil.

17. The surface cleaner composition of claim 14, comprising pine oil and lemongrass oil.

18. The surface cleaner composition of claim 14, comprising lemongrass oil and orange oil.

19. A veterinary product composition comprising (i) one or more essential oil or individual constituent thereof at a concentration between about 0.1 and 1.2 percent (weight/weight);

and (ii) a fruit acid at a concentration between about 0.5 and 1.5 percent (weight/weight);

wherein the veterinary product composition is suitable for use as a product selected from the group consisting of a pet shampoo, a pet cleansing wipe, an ear cleaning liquid, a cage cleaner, a topical cream, a teat dip, or a pet body splash.

20. An antimicrobial composition comprising (i) between about 0.2 and 0.5 percent (weight/weight) of one or more essential oil selected from the group consisting of lemongrass, cinnamon oil, citronella oil, basil oil, orange oil and combinations thereof;

(ii) a non-alkanediol alcohol solvent at a concentration between about 0.5 and 20 percent (weight/weight);

(iii) an amount of alkanediol which increases the antimicrobial effect, and (iv) one or more fruit acid at a total concentration between about 0.125 and 2.0 percent (weight/weight).

21. The composition of claim 20, where the fruit acid is selected from the group consisting of citric acid and lactic acid.

22. The composition of claim 20, where the alkanediol is present at a concentration between about 0.3 and 1.0 percent (weight/weight).

23. The composition of claim 20, where the alkanediol is selected from the group consisting of dodecanediol, decanediol, nonanediol, octanediol, heptanediol, hexanediol and pentanediol.

24. The composition of claim 20 where the alkanediol has a carbon backbone of between 9 and 25 carbon atoms.

25. The composition of claim 24, where the alkanediol is selected from the group consisting of 1,9 Nonanediol, 1,2-Decanediol, 1,10-Decanediol, 1,11-Undecanediol, 1,2-Dodecanediol, 1,12 Dodecanediol, Cyclododecanediol, 1,13-Tridecanediol, 1,2-Tetradecanediol, 1,14-Tetradecanediol, 1,15-Pentadecanediol, 1,16-Hexadecanediol, 1,17-Heptadecanediol, 1,18-Octadecanediol, 1,19-Nonadecanediol, 1,20-Eicosanediol, 1,21-Heneicosanediol, 1,22-Docosanediol, 1,23-Tricosanediol, 1,24-Tetracosanediol, 1,25-Pentacosanediol.

26. The composition of claim 24, where the alkanediol is selected from the group consisting of 1,2-Decanediol, 1,10-Decanediol, 1,2-Dodecanediol, 1,12-Dodecanediol, Cyclododecanediol, 1,13-Tridecanediol, 1,2-Tetradecanediol, 1,14-Tetradecanediol and the most preferred alkanediols are 1,2-Decanediol, 1,2-Dodecanediol and 1,2-Tetradecanediol.

27. The composition of claim 20, where the non-alkanediol alcohol is an aliphatic alcohol.

28. The composition of claim 20, where the non-alkanediol alcohol is an aromatic alcohol.

29. The composition of claim 20, where the non-alkanediol alcohol is selected from the group consisting of methanol, ethanol, n-propanol, isopropyl alcohol, 2-methyl-2 propanol, hexanol, phenoxyethanol, benzyl alcohol, 1-phenoxy-2propanol, and phenethyl alcohol.

30. A personal care product selected from the group consisting of a bar soap, a liquid hand soap, a hand sanitizer, a body wash, an acne treatment, a shampoo, a hair conditioner, a cosmetic, a deodorant, a body lotion, a hand cream, a topical cream, an aftershave lotion, a skin toner, a mouth wash, a toothpaste, a sunscreen lotion, a baby cleansing wipe, and a diaper cream, comprising (i) between about 0.2 and 0.5 percent (weight/weight) of one or more essential oil selected from the group consisting of lemongrass, cinnamon oil, citronella oil, basil oil, orange oil and combinations thereof;

(ii) a non-alkanediol alcohol solvent at a concentration between about 0.5 and 20 percent (weight/weight);

(iii) an amount of alkanediol which increases the antimicrobial effect, and (iv) one or more fruit acid at a total concentration between about 0.125 and 2.0 percent (weight/weight).

31. A household cleaner comprising (i) between about 0.2 and 0.5 percent (weight/weight) of one or more essential oil selected from the group consisting of lemongrass, cinnamon oil, citronella oil, basil oil, orange oil and combinations thereof;

(ii) a non-alkanediol alcohol solvent at a concentration between about 0.5 and 20 percent (weight/weight);

(iii) an amount of alkanediol which increases the antimicrobial effect, and (iv) one or more fruit acid at a total concentration between about 0.125 and 2.0 percent (weight/weight).

32. A veterinary product comprising (i) between about 0.2 and 0.5 percent (weight/weight) of one or more essential oil selected from the group consisting of lemongrass, cinnamon oil, citronella oil, basil oil, orange oil and combinations thereof;

(ii) a non-alkanediol alcohol solvent at a concentration between about 0.5 and 20 percent (weight/weight);

(iii) an amount of alkanediol which increases the antimicrobial effect; and

(iv) one or more fruit acid at a total concentration between about 0.125 and 2.0 percent (weight/weight).

33. A preservative composition comprising (i) between about 10 and 30 percent (weight/weight) of one or more essential oil, (ii) between about 3 and 15 percent (weight/weight), (iii) between about 0.5 and 70 percent (weight/weight) a non-alkanediol alcohol solvent, and (iv) between about 0 and 35 percent (weight/weight) of an alkanediol.

34. The preservative composition of claim 33, wherein between about 0.5 and 5.0 percent of the preservative composition is used in personal care products.

35. A veterinary product comprising (i) between about 0.1 and 5.0 percent (weight/weight) of one or more anti-irritant;

(ii) between about 0.2 and 1.0 percent (weight/weight) of a vehicle containing gelling agent;

(iii) between about 5 and 15 percent (weight/weight) of glycerin;

(iv) between about 50 and 80 percent (weight/weight) water;

(v) between about 0.2 and 2 percent antimicrobial agents comprising botanicals;

(vi) between about 0.5 and 15 percent (weight/weight) of one or more alcohols; and

(vii) between about 0.3 and 1 percent (weight/weight) of an alkanediol.