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ABUSE RESISTANT MELT EXTRUDED FORMULATION HAVING REDUCED ALCOHOL INTERACTION

  • US 20100172989A1
  • Filed: 12/04/2009
  • Published: 07/08/2010
  • Est. Priority Date: 01/21/2006
  • Status: Abandoned Application
First Claim
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1. A melt-extruded dosage form having reduced drug-alcohol interaction, comprising:

  • (a) a drug comprising an opioid or salt, hydrate or mixture thereof having potential for dose dumping in alcohol, and a non-opioid analgesic or salt, hydrate or mixture thereof having a potential for dose dumping in alcohol; and

    (b) a matrix having a polymer, copolymer or combinations thereof wherein the monomer is selected from a group consisting of cellulose ether, cellulose ester, acrylic acid ester, methacrylic acid ester, vinyl alcohol, ethylene oxide and natrium-alginate.wherein the matrix is melt extruded;

    wherein the dosage form provides a controlled dissolution rate of the drug that is sufficient to prevent dose dumping of the drug when the dosage form is co administered to the patient with up to about 40% alcohol; and

    wherein the dosage form is adapted so as to be useful for oral administration to a human 3, 2, or 1 times daily.

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