IN-SITU REFILLABLE OPHTHALMIC IMPLANT
First Claim
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1. An in-situ refillable ophthalmic implant, comprising:
- a body portion defining a reservoir;
a fill portion defining a fill port that is in fluid communication with the reservoir for allowing a pharmaceutical composition to be repeatedly located within the reservoir, the pharmaceutical composition including a therapeutic agent; and
a release control mechanism having at least one opening suitable for providing a controlled passive release of the pharmaceutical composition into the eye over an extended time period;
wherein, upon application of the implant to the eye, the release control mechanism is located within the eye and the fill portion is located outside the vitreous of the eye adjacent the sclera of the eye such that the fill port remains accessible outside of the vitreous of the eye.
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Abstract
The present invention is directed to an in-situ refillable ophthalmic implant having a refill port in communication with a reservoir and a release control mechanism. The present invention also relates to methods of forming and using the ophthalmic implant. Preferably, the control release mechanism include opening[s] providing for passive passage of pharmaceutical ophthalmic composition, particularly therapeutic agent, out of the reservoir, through the opening[s] and into the eye.
96 Citations
20 Claims
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1. An in-situ refillable ophthalmic implant, comprising:
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a body portion defining a reservoir; a fill portion defining a fill port that is in fluid communication with the reservoir for allowing a pharmaceutical composition to be repeatedly located within the reservoir, the pharmaceutical composition including a therapeutic agent; and a release control mechanism having at least one opening suitable for providing a controlled passive release of the pharmaceutical composition into the eye over an extended time period; wherein, upon application of the implant to the eye, the release control mechanism is located within the eye and the fill portion is located outside the vitreous of the eye adjacent the sclera of the eye such that the fill port remains accessible outside of the vitreous of the eye. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. An in-situ refillable ophthalmic implant, comprising:
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a body portion defining a reservoir; a fill portion defining a fill port that is in fluid communication with the reservoir for allowing a pharmaceutical composition to be repeatedly located within the reservoir, the pharmaceutical composition including a therapeutic agent; and a release control mechanism having multiple openings suitable for providing a controlled passive release of the pharmaceutical composition into the eye over an extended time period; wherein, upon application of the implant to the eye, the release control mechanism is located within the vitreous of the eye and the fill portion is located outside the vitreous of the eye adjacent the sclera of the eye such that the fill port remains accessible outside of the vitreous of the eye; and wherein the body portion, the fill portion or a combination thereof define a contact surface that is disposed over the sclera upon application of the implant to the eye; and wherein the control release mechanism includes a silicon disc through which the multiple openings extend; and wherein each of the multiple openings has a cross-sectional area that is at least 8 microns2 but is no greater than 4000 microns2. - View Dependent Claims (17, 18, 19, 20)
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Specification