RECANALIZATION/REVASCULARIZATION AND EMBOLUS ADDRESSING SYSTEMS INCLUDING EXPANDABLE TIP NEURO-MICROCATHETER

• US 20100174309A1
• Filed: 12/31/2009
• Published: 07/08/2010
• Est. Priority Date: 05/19/2008
• Status: Abandoned Application

• Current Assignee: Covidien LP (Medtronic Plc)
• Original Assignee: Mindframe LLC
• Inventors: FULKERSON, JOHN, Ferrera, David A., Cragg, Andrew
• Application Number:
  US12/651,353
• Publication Number:
  US 20100174309A1
• Time in Patent Office: Days
• US Class Current: 606/200
• CPC Class Codes: A61B 17/221 Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions surgical snare instruments A61B17/32056
• CPC Class Codes: A61B 17/3207 Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions A61B17/32037 takes precedence; endoscopic cutting instruments A61B17/320016
• CPC Class Codes: A61B 17/320725 with radially expandable cutting or abrading elements A61B17/32075 takes precedence
• CPC Class Codes: A61B 2017/00845 of moving parts with respect to each other
• CPC Class Codes: A61B 2017/00867 shape memory effect for prostheses A61F2210/0014
• CPC Class Codes: A61B 2017/22038 with a guide wire
• CPC Class Codes: A61F 2/013 Distal protection devices, i.e. devices placed distally in combination with another endovascular procedure, e.g. angioplasty or stenting
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2002/91558 connected peak to peak
• CPC Class Codes: A61F 2230/005 Rosette-shaped, e.g. star-shaped
• CPC Class Codes: A61F 2230/0054 V-shaped
• CPC Class Codes: A61F 2230/0067 conical
• CPC Class Codes: A61F 2250/0059 temporary
• CPC Class Codes: A61M 2025/1095 with perfusion means for enabling blood circulation while the balloon is in an inflated state or in a deflated state, e.g. permanent by-pass within catheter shaft
• CPC Class Codes: A61M 2025/1097 with perfusion means for enabling blood circulation only while the balloon is in an inflated state, e.g. temporary by-pass within balloon
• CPC Class Codes: A61M 29/02 Dilators made of swellable material balloon catheters for angioplasty A61M25/104

Abstract

An acute stroke recanalization systems and processes include catheter-based improved reconstrainable or tethered neurological devices which are deliverable through highly constricted and tortuous vessels, crossing the zone associated with subject thrombi/emboli, where deployment impacts, addresses or bridges the embolus, compacting the same into lumenal walls which enables perfusion and lysis of the embolus, while the improved neurological medical device itself remains contiguous with the delivery system acting as a filter, basket or stand alone alternate medical device, depending on the status of the embolus and other therapeutic aspects of the treatment being offered for consideration.

Claims

1. An acute stroke system comprising, in combination:

a catheter with a guidewire effective for accessing of, and emplacement into, the cerebral vasculature;

an expandable stroke device tethered to the catheter and compressible within the catheter and radially expandable with a plurality of open cells defined by struts connected by bridges;

wherein the stroke device is configured to address a vascular clot by the flexion/extension of the stroke device upon expansion;

wherein each strut of the stroke device has a strut width and a strut thickness providing effective pinching stiffness and hoop stiffness for compressing the vascular clot to promote at least one of lysis, maceration, and removal thereof without compromising trackability of the stroke device.

2. The acute stroke system of claim 1, wherein the stroke device has an average COF per unit length across a diameter of 2.0 mm to 4.5 mm of between at least about 0.0025 N/mm and at least about 0.007 N/mm.

3. The acute stroke system of claim 1, wherein the stroke device has an average COF per unit length across a diameter of 2.0 mm to 4.5 mm of between at least about 0.0030 N/mm and at least about 0.0059 N/mm.

4. The acute stroke system of claim 1, wherein the stroke device has a COF range per unit length across a diameter of 2.0 mm to 4.5 mm of between at least about 0.00165 N/mm and at least about 0.0090 N/mm.

5. The acute stroke system of claim 1, wherein the stroke device has a RRF range per unit length across a diameter of 2.0 mm to 4.5 mm of between at least about 0.005 N/mm and at least about 0.016 N/mm.

6. The acute stroke system of claim 1, wherein the hoop stiffness of the pinching device is defined by the strut width, according to Eq. 7.

7. The acute stroke system of claim 1, wherein the pinching stiffness of the stroke device is defined by the strut thickness, according to Eq. 8.

8. The acute stroke system of claim 1, wherein the ratio of strut thickness to strut width is less than at least about 1.4.

9. The acute stroke system of claim 1, wherein the strut thickness is substantially equal to the strut width.

10. A stroke device comprising, in combination:

a structure having a substantially radial geometry, being tethered to a catheter, and having plurality of open cells defined by struts connected by bridges, said stroke device being radially expandable from a first state to a second state, wherein expansion to said second state provides effective maceration of a clot to which stroke device is applied during expansion to said second state; and

wherein each of said open cells has a length from about 0.120″

to about 0.250″

in said second state and a cell height from about 0.050″

to about 0.100″

in said second state, wherein said open cells are effective for promoting at least one of lysis, maceration, and removal of said clot.

11. The stroke device of claim 10, wherein each of said open cells has a substantially equal area of about 0.010 sq. inches to about 0.020 sq. inches.

12. The stroke device of claim 10, wherein the open cells vary throughout the stroke device having an area of between about 0.010 sq. inches and about 0.020 sq. inches.

13. An acute stroke system comprising, in combination:

a stroke device further comprising struts and bridges, wherein each strut has two ends, with each end connected to a bridge, wherein each bridge is connected to four struts, wherein the struts define open cells of the stroke device, each open cell being defined by four struts.

14. The stroke device of claim 13, wherein each strut is substantially linear.

15. The stroke device of claim 13, wherein each open cell is substantially diamond-shaped.

16. The stroke device of claim 13, wherein each bridge is substantially “

C”

shaped.

17. The stroke device of claim 13, wherein each bridge is substantially “

S”

shaped.

18. An acute stroke system comprising, in combination:

a stroke device further comprising struts and bridges, wherein each strut has two ends, with each end connected to a bridge, wherein each bridge is connected to three struts, wherein the struts define open cells of the stroke device, each open cell being defined by six struts.

19. The stroke device of claim 18, wherein each strut is substantially linear.

20. The stroke device of claim 18, wherein each open cell is substantially parallelogram-shaped.