RESPIRATORY SENSOR

• US 20100175699A1
• Filed: 04/10/2008
• Published: 07/15/2010
• Est. Priority Date: 04/10/2007
• Status: Abandoned Application

• Current Assignee: Anaxsys Technology Limited
• Original Assignee: Anaxsys Technology Limited
• Inventors: Varney, Mark, Garrett, Michael, Beadle, John, Williams, Deryk
• Application Number:
  US12/595,536
• Publication Number:
  US 20100175699A1
• Time in Patent Office: Days
• US Class Current: 128/204.230
• CPC Class Codes: A61B 5/0816 Measuring devices for examining respiratory frequency measuring frequency of electric signals G01R23/00
• CPC Class Codes: A61B 5/087 Measuring breath flow
• CPC Class Codes: A61B 5/4806 Sleep evaluation A61B5/4821 takes precedence; devices for inducing sleep A61M21/02
• CPC Class Codes: A61B 5/4818 Sleep apnoea
• CPC Class Codes: A61M 16/0051 with alarm devices
• CPC Class Codes: A61M 16/024 including calculation means, e.g. using a processor
• CPC Class Codes: A61M 16/0672 Nasal cannula assemblies for oxygen therapy
• CPC Class Codes: A61M 16/08 Bellows; Connecting tubes having means for taking samples G01N1/22; Water traps; Patient circuits
• CPC Class Codes: A61M 16/161 with means for measuring the humidity
• CPC Class Codes: A61M 2016/0036 in the breathing tube and used in both inspiratory and expiratory phase
• CPC Class Codes: A61M 2202/062 Desiccants
• CPC Class Codes: A61M 2205/0233 Conductive materials, e.g. antistatic coatings for spark prevention
• CPC Class Codes: A61M 2205/0244 Micromachined materials, e.g. made from silicon wafers, microelectromechanical systems [MEMS] or comprising nanotechnology
• CPC Class Codes: A61M 2205/3317 Electromagnetic, inductive or dielectric measuring means
• CPC Class Codes: A61M 2205/502 User interfaces, e.g. screens or keyboards
• CPC Class Codes: A61M 2205/8206 battery-operated
• CPC Class Codes: A61M 2230/30 Blood pressure A61M2230/04 takes precedence
• CPC Class Codes: A61M 2230/42 Rate
• CPC Class Codes: A61M 2230/435 partial O2 pressure (P-O2)
• CPC Class Codes: G01N 27/121 for determining moisture content, e.g. humidity, of the fluid moisture content of the tested material G01N27/048

Abstract

A sensor assembly for monitoring the respiration pattern of a subject is disclosed, the sensor comprising a sensor element for exposing to a gas stream exhaled by the subject comprising a first electrode, a second electrode and an active layer extending between the first and second electrodes to provide an electrical path therebetween, the sensor element being responsive to the concentration of water vapour in the gas stream exhaled by the subject, whereby the conductivity of the path between the electrodes varies in response to changes in the concentration of water vapour; a processor for determining the pattern of respiration of the subject; and means for displaying information relating to the determined respiration pattern to a user. The sensor assembly is particular suitable for measuring the respiration rate and/or depth of respiration of the subject. The sensor and method find particular application in the diagnosis and treatment of sleep apnea.

Claims

1. A sensor assembly for monitoring the respiration pattern of a subject, the sensor comprising:

a sensor element for exposing to a gas stream exhaled by the subject comprising a first electrode, a second electrode and an active layer extending between the first and second electrodes to provide an electrical path therebetween, the sensor element being responsive to the concentration of water vapour in the gas stream exhaled by the subject, whereby the conductivity of the path between the electrodes varies in response to changes in the concentration of water vapour;

a processor for determining the pattern of respiration of the subject; and

means for displaying information relating to the determined respiration pattern to a user.

2. The sensor assembly according to claim 1, wherein the respiration pattern comprises the respiration rate of the subject, the processor determining the respiration rate of the subject.

3. The sensor assembly according to claim 1, wherein the respiration pattern comprises the depth of respiration of the subject, the processor determining the depth of respiration of the subject.

4. The sensor assembly according to claim 3, wherein the processor is adapted to integrate data generated by the sensor element relating to the concentration of water vapour and time of the exhalation to determine the depth of respiration.

5. The sensor assembly according to claim 1, wherein the sensor element is disposed in an assembly for attaching on or around the face of the subject.

6. The sensor assembly according to claim 5, wherein the sensor element is disposed within a mask to be worn by the subject.

7. The sensor assembly according to claim 5, wherein the sensor element is mountable on the upper lip of the subject.

8. The sensor assembly according to claim 7, wherein the sensor element is disposed within an open ended conduit for extending longitudinally between the mouth and nose of the subject.

9. The sensor assembly according to claim 5, wherein the sensor element is disposed in a line for supplying gases to the subject.

10. The sensor assembly according to claim 1, wherein the sensor element is adapted for location within the nasal passages or cannulae of the subject.

11. The sensor assembly according to claim 1, wherein the sensor element is wirelessly connected to the processor.

12. The sensor assembly according to claim 1, further comprising means to remove moisture from the sensor element between exhalations of the subject.

13. The sensor assembly according to claim 12, wherein the sensor element is disposed to be contacted by the gas stream being inhaled by the subject.

14. The sensor assembly according to claim 12, wherein the sensor element is disposed to be contacted by a stream of pressurized gas supplied to the sensor assembly.

15. The sensor assembly according to claim 1, wherein the active layer of the sensor element comprises a porous material.

16. The sensor assembly according to claim 15, wherein the porous material is a zeolite.

17. The sensor assembly according to claim 1, wherein the active layer comprises an ion-exchange material.

18. The sensor assembly according to claim 17, wherein the ion exchange material is a sulphonated tetrafluoroethylene copolymer.

19. The sensor assembly according to claim 17, wherein the active layer comprises an ion-exchange material and a zeolite, the zeolite being in the form of particles distributed in a fine dispersion through the ion exchange material.

20. The sensor assembly according to claim 1, wherein the active layer has a thickness of from 1 to 1000 nm, preferably from 5 to 500 nm, more preferably from 10 to 100 nm.

21. The sensor assembly according to claim 1, wherein the sensor element comprises a third electrode.

22. The sensor assembly according to claim 1, wherein the electrodes are of copper, gold or platinum.

23. The sensor assembly according to claim 1, wherein the electrodes are supported on an inert substrate.

24. The sensor assembly according to claim 23, wherein the electrodes are formed on the surface of the inert substrate by thick film screen printing.

25. The sensor assembly according to claim 1, wherein the electrodes each comprise a plurality of electrode portions, the electrode portions being arranged in an interdigitated array.

26. The sensor assembly according to claim 1, further comprising a sensor element responsive to one or more other components in the exhaled gas stream of the subject.

27. The sensor assembly according to claim 1, further comprising means for measuring the cardiac output of the subject.

28. The sensor assembly according to claim 27, wherein the said means are located in contact with the nasal septum of the subject.

29. The sensor assembly according to claim 28, further comprising means for stimulating the subject to change the level of arousal of the subject.

30. The sensor assembly according to claim 1, further comprising a CPAP device.

31. A method of monitoring the respiration pattern of a subject, the method comprising:

contacting a gas stream exhaled by the subject with the sensor element of an electrochemical sensor assembly, thereby generating an signal from the sensor element in response to changes in the concentration of water vapour in the exhaled gas stream;

processing the electrical signal to determine the respiration pattern of the subject; and

generating a display of information relating to the respiration pattern for a user.

32. The method according to claim 31, wherein the method comprises contacting the sensor element with exhaled gas streams during tidal breathing.

33. The method according to claim 31, wherein a voltage is applied across the electrodes of the electrochemical sensor assembly.

34. The method according to claim 33, wherein the voltage is a constant voltage.

35. The method according to claim 33, wherein the voltage is varied with time.

36. The method according to claim 31, wherein the method determines the respiration rate of the subject.

37. The method according to claim 31, wherein the method determines the depth of respiration of the subject.

38. The method according to claim 37, wherein the depth of respiration is determined by integration of the data relating to concentration of water vapour over time of the exhaled gas stream.

40. The method according to claim 31, further comprising stimulating the subject upon detection of an erratic respiration pattern.

41. The method according to claim 40, wherein the subject is stimulated sufficient to arouse them from REM sleep.

42. The method according to claim 31, further comprising administering a stream of pressurized gas to the nose and/or mouth of the subject upon detection of an erratic respiration pattern.

43. The method according to claim 31, wherein the respiration of the subject is monitored over a plurality of breaths.

44. The method according to claim 43, wherein the respiration of the subject is monitored during tidal breathing.

45. The method according to claim 31, wherein the method is used in diagnosing a subject with sleep apnea.

55. The method according to claim 31, wherein the method is used in training the metabolism of a subject.

56. The method according to claim 31, wherein the method is used in training the lung function of a subject.

39. (canceled)

46. A system for the treatment of a subject with sleep apnea, the system comprising:

means for monitoring the respiration pattern of the subject;

means for administering to the subject a stream of pressurized gas sufficient to open the airways of the subject when activated by the means for monitoring the respiration pattern.

48. The system according to claim 46, further comprising means for stimulating the subject sufficient to change the level of arousal of the subject.

47. (canceled)

49. A method of treating a subject with sleep apnea, the method comprising the steps of:

monitoring the respiration pattern of the subject; and

upon detection of a erratic respiration pattern indicating the onset of an apneic event, initiating the supply of a stream of pressurized gas to the nose and/or mouth of the subject sufficient to maintain the airways of the subject open.

50. (canceled)

51. (canceled)

52. (canceled)

53. A system for providing a continuous positive airway pressure to a subject, the system comprising:

means for monitoring the respiration pattern of the subject;

means for delivering a stream of gas to the subject sufficient to maintain a continuous positive airway pressure within the subject; and

means for controlling the means for delivering the stream of gas responsive to the output from the means for monitoring the respiration pattern of the subject.

54. (canceled)