EXTENDED RELEASE OF BIOACTIVE MOLECULES FROM SILICONE HYDROGELS
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Accused Products
Abstract
A dosage form for the administration of a biologically active agent is a silicone hydrogel appliance where the agent is absorbed in a copolymer of at least one siloxane containing monomer and at least one hydrophilic monomer where the appliance is placed in contact with a tissue surface of the patient, such as a contact lens placed in the eye. The appliance can be formed where a copolymer of the siloxane containing and hydrophobic monomers is soaked in a solution of the biologically active agent. The agent can be a non-ionic drug which is absorbed into the appliance from a non-aqueous solution, such as an ethanol solution.
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Citations
69 Claims
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1-35. -35. (canceled)
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36. A method of controlled release of bioactive agents from a silicone hydrogel appliance comprising:
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providing a silicone hydrogel article; absorbing at least one of said bioactive agents into said article to form said appliance; and placing said appliance onto a tissue surface of a patient to be treated with said agent, wherein said agent partitions between said appliance and said tissue to release said agent from said appliance over a period of about 7 hours to about 6 weeks without a burst release of said agent. - View Dependent Claims (37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59)
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- 60. A sustained-release dosage form for administration of a bioactive agent to a tissue surface comprising a silicone hydrogel article containing said bioactive agent in a therapeutically effective amount with release to the tissue surface occurring over a period of about 7 hours to about 6 weeks.
Specification