HAIR FOLLICLE GRAFT FROM TISSUE ENGINEERED SKIN
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Abstract
The present invention provides a hair graft comprising (a) tissue engineered skin comprising a tissue engineered epidermal layer, a tissue engineered dermal layer, and hair follicle progenitor cells and (b) a scaffold. The invention also provides methods of making and using the hair grafts of the present invention.
99 Citations
11 Claims
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1-9. -9. (canceled)
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10. A method of making a hair graft, comprising:
- a) placing a tissue engineered dermal layer on a bioabsorbable scaffold;
b) placing hair follicle progenitor cells on the tissue engineered dermal layer;
c) placing a tissue engineered epidermal layer on the hair follicle progenitor cells to form a construct;
d) allowing the construct to mature in vitro; and
e) cutting the construct into implantable grafts.
- a) placing a tissue engineered dermal layer on a bioabsorbable scaffold;
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11. A method of implanting a hair graft comprising creating a wound in skin of a subject and implanting the graft wherein the graft comprises (a) tissue engineered skin having a tissue engineered epidermal layer, a tissue engineered dermal layer, and hair follicle progenitor cells;
- and (b) a scaffold, wherein the graft is at least about 2 millimeters thick into a wound.
Specification