CURCUMIN CYCLODEXTRIN COMBINATION FOR PREVENTING OR TREATING VARIOUS DISEASES
First Claim
1. A curcumin cyclodextrin complex having enhanced bioavailability and/or efficacy, irrespective of the ratio of curcumin and cyclodextrin
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Abstract
Curcumin has shown anti-inflammatory and anti-angiogenic properties that could be useful in treating various diseases such as those of rheumatology and oncology. However, curcumin is very poorly absorbed and has a very low bioavailability. This patent describes a method of increasing the delivery of curcumin by complexing it with cyclodextrins. Cyclodextrins are well known in the food industry and have been used to carry other drugs to increase bioavailability. The new combination of cyclodextrins and curcumin has been tested in pre-clinical inflammation models where it has demonstrated efficacy superior to both the positive control and curcumin.
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10 Claims
- 1. A curcumin cyclodextrin complex having enhanced bioavailability and/or efficacy, irrespective of the ratio of curcumin and cyclodextrin
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