POLYMERS WITH BIO-FUNCTIONAL SELF ASSEMBLING MONOLAYER ENDGROUPS FOR THERAPEUTIC APPLICATIONS AND BLOOD FILTRATION
First Claim
1. An in vitro, ex vivo, or in vivo medical device or prosthesis or packaging assembly comprising a polymer body comprising at least one polymer having the formula
R(LE)x whereinR is a polymeric core having a number average molecular weight of from 5,000 to 7,000,000 daltons, and having x endgroups,x is an integer≧
- 1,E is an endgroup covalently linked to polymeric core R by linkage L,L is a divalent oligomeric chain having at least 5 repeat units and is capable of self-assembly with L chains on adjacent molecules of the polymer, and the moieties L and/or E in the polymer(s) may be the same as or different from one another in composition and/or molecular weight, wherein the polymer body comprises a plurality of polymer molecules located internally within said body, at least some of which internal polymer molecules have endgroups that comprise a surface of the body, wherein the surface endgroups include at least one self-assembling moiety.
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Accused Products
Abstract
Medical device, prosthesis, or packaging assembly made up of polymer body comprising at least one polymer having the formula R(LE)x wherein R is a polymeric core having a number average molecular weight of from 5000 to 7,000,000 daltons, and having x endgroups, x is an integer≧1, E is an endgroup which is covalently linked to polymeric core R by linkage L, L is a divalent oligomeric chain which has at least 5 repeat units and which can self-assembly with L chains on adjacent molecules of the polymer, and moieties L and/or E in the polymer(s) may be the same as or different from one another in composition and/or molecular weight. The polymer body includes plural polymer molecules located internally within the body, at least some of which internal polymer molecules have endgroups that form a surface of the body. The surface endgroups include at least one self-assembling moiety.
24 Citations
32 Claims
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1. An in vitro, ex vivo, or in vivo medical device or prosthesis or packaging assembly comprising a polymer body comprising at least one polymer having the formula
R(LE)xwherein R is a polymeric core having a number average molecular weight of from 5,000 to 7,000,000 daltons, and having x endgroups, x is an integer≧ - 1,
E is an endgroup covalently linked to polymeric core R by linkage L, L is a divalent oligomeric chain having at least 5 repeat units and is capable of self-assembly with L chains on adjacent molecules of the polymer, and the moieties L and/or E in the polymer(s) may be the same as or different from one another in composition and/or molecular weight, wherein the polymer body comprises a plurality of polymer molecules located internally within said body, at least some of which internal polymer molecules have endgroups that comprise a surface of the body, wherein the surface endgroups include at least one self-assembling moiety. - View Dependent Claims (2, 3, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 32)
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4-16. -16. (canceled)
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29. A method of immobilizing biologically-active entities, including proteins, peptides, and polysaccharides, at a surface of a polymer body, which polymer body surface comprises a surface of an interface, which method comprises the sequential steps of
contacting the polymer body surface with a medium that delivers self-assembling monolayer moieties containing chemically-reactive groups, capable of binding biologically-active entities to the surface, to the polymer body surface by interaction of chemical groups, chains, or oligomers, said self-assembling monolayer moieties being covalently or ionically bonded to a polymer in the body and comprising one or more chemical groups, chains, or oligomers that spontaneously assemble in the outermost monolayer of the surface of the polymer body or one or more chemical groups, chains, or oligomers that spontaneously assemble within that portion of the polymer body that is at least one monolayer away form the outermost monolayer of the polymer body surface, and binding said biologically-active entities to said reactive groups, wherein the polymer comprising the self-assembling monolayer moieties in the polymer body is a first polymer making up the entirety of a major portion of the body and having a weight average molecular weight in the range 5,000-5,000,000 daltons, or is a second polymer, having a weight average molecular weight in the range 1,000-500,000 daltons, which comprises an additive to the first polymer making up the entirety or a major portion of the body, or wherein said self-assembling monolayer moieties containing binding groups comprise methoxy ether-terminated polyethyleneoxide oligomers having one or more amino, hydroxyl, carboxaldehyde, or carboxyl groups along the polyethyleneoxide chain.
Specification